Mclean Hospital: Bipolar Disorder trials

The registry lists 33 Bipolar Disorder studies with Mclean Hospital as lead sponsor. 4 are open to participants now and 21 have results posted.

Early Phase 1 1Phase 1 1Phase 2 7Phase 3 1Phase 4 2No phase 21(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Open Label Extension Study of NCT06221852Enrolling by invitationNCT06558201Not applicable
• Ketogenic and Nutritional Interventions for First Episode Bipolar DisorderRecruitingNCT06221852Not applicable
• Enhanced Coordinated Specialty Care for Early PsychosisRecruitingNCT06071858Not applicable
• Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar DisorderRecruitingNCT05457465Phase 2
• Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot StudyCompletedNCT05380583Not applicableResults posted
• Families With Substance Use and Psychosis: A Pilot StudyCompletedNCT04284813Not applicableResults posted
• Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias ModificationCompletedNCT03509181Not applicableResults posted
• An Extended-Release Form of Clonidine as an Anti-Manic Agent: An Add-on, Open-Label StudyTerminatedNCT03065933Phase 4Results posted
• LFMS: Initial Trial in Geriatric Bipolar DepressionTerminatedNCT02707276Not applicableResults posted
• Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) StudyCompletedNCT02642029Not applicableResults posted
• Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserineCompletedNCT02304432Early Phase 1Results posted
• Fixed Dose Intervention Trial of New England Enhancing Survival in SMI PatientsCompletedNCT02188121Phase 4Results posted
• Brain Mechanisms of Human MotivationCompletedNCT01976975Results posted
• Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar DepressionCompletedNCT01929681Not applicableResults posted
• Neurobiology of a Mutation in Glycine Metabolism in Psychotic DisordersCompletedNCT01720316Phase 2Results posted
• Treatment to Enhance Cognition in Bipolar DisorderCompletedNCT01470781Not applicableResults posted
• Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar DepressionCompletedNCT01390389Not applicableResults posted
• A Trial of SAMe for Treatment-Resistant Bipolar DepressionCompletedNCT00762268Not applicableResults posted
• Lamotrigine Therapy in Geriatric Bipolar DepressionCompletedNCT00720473Not applicableResults posted
• CoQ10 in Geriatric Bipolar DepressionCompletedNCT00720369Not applicableResults posted
• The Use of a Mitochondrial Enhancement Treatment in Bipolar DisorderCompletedNCT00719706Phase 2Results posted
• Low Field Magnetic Stimulation in Mood Disorders Using the LFMS DeviceCompletedNCT00578383Not applicableResults posted
• Riluzole in the Treatment of Bipolar DepressionCompletedNCT00544544Not applicableResults posted
• Effects of Pentazocine Versus Lorazepam on Manic SymptomsCompletedNCT00431184Phase 2Results posted
• Effects of Pentazocine on Manic SymptomsCompletedNCT00125931Phase 2Results posted
• Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar DisorderStatus unknownNCT05209217
• Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar DepressionActive, not recruitingNCT03484494Not applicable
• Effects of Electroconvulsive Therapy (ECT) in Bipolar DepressionWithdrawnNCT01557933
• Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 TreatmentsSuspendedNCT01557192Phase 1
• Cytidine and Omega-3 Fatty Acids in Bipolar DisorderCompletedNCT00854737Phase 2
• Change in Brain Bioenergetics in Bipolar Disorder in Response to Photic StimulationWithdrawnNCT00801567Not applicable
• Low Field Magnetic Stimulation Treatment for Bipolar DepressionTerminatedNCT00217217Phase 3
• Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled StudyCompletedNCT00217165Phase 2