Massachusetts General Hospital: Bipolar Disorder trials

The registry lists 63 Bipolar Disorder studies with Massachusetts General Hospital as lead sponsor. 5 are open to participants now and 21 have results posted.

Early Phase 1 1Phase 1 2Phase 2 4Phase 3 2Phase 4 22No phase 33(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar DepressionRecruitingNCT07699445Phase 4
• Time Restricted Eating (TRE) in Bipolar DisorderRecruitingNCT07211217Not applicable
• Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar DisorderRecruitingNCT06274567Not applicable
• Adapting the Tumor Board Model for Mental Illness and CancerRecruitingNCT05837598Not applicable
• Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric PopulationsRecruitingNCT04296604Not applicable
• Pilot Study of Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood DisordersCompletedNCT03622749Not applicableResults posted
• Bridge: Proactive Psychiatry Consultation and Case Management for Patients With CancerCompletedNCT03360695Not applicableResults posted
• Integrated Smoking Cessation Treatment for Smokers With Serious Mental IllnessCompletedNCT02845440Not applicableResults posted
• Online Yoga for Individuals With Mood DisordersCompletedNCT02610725Not applicableResults posted
• Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum DisordersCompletedNCT02357290Phase 4Results posted
• Pilot Study of Cognitive Behavioral Therapy for Anxiety and Bipolar I DisorderCompletedNCT01892306Not applicableResults posted
• Adjunctive Isradipine for the Treatment of Bipolar DepressionTerminatedNCT01784666Phase 2Results posted
• Simvastatin Augmentation of Lithium Treatment in Bipolar DepressionTerminatedNCT01665950Phase 2Results posted
• Nutrition, Exercise, and Wellness Treatment (NEW Tx) for Bipolar DisorderCompletedNCT01615367Phase 1/2Results posted
• Comparative Effectiveness Study for Bipolar DisorderCompletedNCT01331304Phase 4Results posted
• Omega-3 Fatty Acids (Lovaza) for Second Generation Antipsychotic-Associated HypertriglyceridemiaCompletedNCT00833976Phase 4Results posted
• A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar DisorderCompletedNCT00621777Phase 4Results posted
• Fluoxetine for Obsessive-Compulsive Disorder in Children and Adolescents With Bipolar DisorderTerminatedNCT00592852Phase 4Results posted
• Omega-3 Fatty Acid Adjunctive to Open-Label Aripiprazole for the Treatment of Bipolar Disorder in Children and AdolescentsTerminatedNCT00592683Phase 4Results posted
• Invega (Paliperidone) for the Treatment of Mania in Children and Adolescents Ages 6-17 With Bipolar DisorderTerminatedNCT00592358Phase 4Results posted
• Memantine and Cognitive Dysfunction in Bipolar DisorderCompletedNCT00586066Phase 4Results posted
• Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in FemalesTerminatedNCT00575328Phase 3Results posted
• The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive FunctioningCompletedNCT00566735Phase 3Results posted
• Ziprasidone for the Treatment of Generalized Anxiety in Patients With Bipolar DisorderTerminatedNCT00374543Phase 4Results posted
• Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar DisorderCompletedNCT00181883Phase 4Results posted
• Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar DisorderCompletedNCT00181844Phase 4Results posted
• A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar DisorderActive, not recruitingNCT06609902Not applicable
• Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood DisordersCompletedNCT04284267Not applicable
• Mechanism of Action of Electroconvulsive TherapyCompletedNCT04059952
• Suvorexant (Belsomra) for the Treatment of Bipolar Depression With InsomniaWithdrawnNCT03764683Phase 4
• Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar DisorderCompletedNCT03748446Early Phase 1
• Measuring Beliefs and Norms About Persons With Mental IllnessCompletedNCT03656770Not applicable
• A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar DepressionWithdrawnNCT02719392Phase 4
• Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental IllnessCompletedNCT02594696Not applicable
• BezafibrateTreatment for Bipolar Depression: A Proof of Concept StudyCompletedNCT02481245Phase 2
• Mood Patient Powered Research Network (MoodNetwork)CompletedNCT02453438
• An fMRI Study on Temporal Discounting in Bipolar DisorderCompletedNCT02323763
• Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) StudyCompletedNCT02253225
• Enhancing Outcomes, Reducing Costs: Evaluating Peer Support for Mood DisordersCompletedNCT02242669
• Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years OldWithdrawnNCT01932541Phase 4
• Positive Psychology for Mood DisordersCompletedNCT01820286Not applicable
• Brief Sleep Intervention for Bipolar DisorderCompletedNCT01764074Not applicable
• Mindfulness Therapy on Disrupted Sleep in Bipolar DisorderCompletedNCT01764035Not applicable
• Neuroimaging Studies of the Treatment of Bipolar Depression With CitalopramCompletedNCT01639482
• Complex Dynamic Systems in Mood DisordersCompletedNCT01583569
• Brain Activity Flow Patterns Analysis Using Evoked Response Potentials in Youth With ADHD, Bipolar Disorder, or Autism Spectrum Disorders: A Preliminary StudyTerminatedNCT01506232
• Emotion Regulation Group Therapy for Bipolar DisorderCompletedNCT01207505Not applicable
• Cognitive-Behavior Therapy for Young Adults With Bipolar DisorderCompletedNCT01176825Phase 1
• Mindfulness-Based Cognitive Behavior Therapy for Bipolar DisorderCompletedNCT01126827Not applicable
• Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improvement With Treatment of Depressive SymptomsCompletedNCT00844974Not applicable
• Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I DisorderCompletedNCT00595387Not applicable
• Screening Protocol for Children and Adolescents With Bipolar and Bipolar Spectrum DisorderStatus unknownNCT00592267
• Bipolar Disorder in Pregnancy and the Postpartum Period: Predictors of MorbidityCompletedNCT00580268
• Determining the Safety and Effectiveness of Olanzapine in Children and AdolescentsTerminatedNCT00183612Not applicable
• Concerta in the Treatment of ADHD in Youth and Adults With Bipolar DisorderCompletedNCT00181987Phase 4
• Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar DisorderCompletedNCT00181935Phase 4
• Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar DisorderCompletedNCT00181922Phase 4
• Bupropion SR for Major Depression and Depression NOS in Children and Adolescents With Bipolar DisorderTerminatedNCT00181896Phase 4
• Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar DisorderCompletedNCT00181870Phase 4
• Spectroscopy in Children and Adolescents With Bipolar DisorderCompletedNCT00181831
• Aripiprazole for the Treatment of Mania in Children and Adolescents With Bipolar DisorderCompletedNCT00181779Phase 4
• Study of Depakote ER for the Treatment of Mania in Children Ages 6-12 With Bipolar DisorderCompletedNCT00181727Phase 4
• Galantamine-CR and Cognitive Dysfunction in Bipolar DisorderCompletedNCT00181636Not applicable