Pure Autonomic Failure clinical trials

The registry lists 56 studies for Pure Autonomic Failure across more than 10 countries. 10 are recruiting or about to start. 17 of them are mainly about Pure Autonomic Failure (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.

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Status

Completed: 31
Terminated: 10
Recruiting: 9
Withdrawn: 2
Status unknown: 2
Active, not recruiting: 1

Phase

Phase 1: 9
Phase 3: 8
Phase 2: 6
Early Phase 1: 3
Phase 4: 1

Where

United States: 45
Canada: 7
Germany: 7
Australia: 5
France: 5
New Zealand: 5

Who runs them

Vanderbilt University (12) · Vanderbilt University Medical Center (11) · National Institute of Neurological Disorders and Stroke (NINDS) (5) · Chelsea Therapeutics (4) · Theravance Biopharma (4) · H. Lundbeck A/S (2) · RWTH Aachen University (2) · NYU Langone Health (2)

What is being tested here

Drugs under test in Pure Autonomic Failure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Fluorodopa F 18	1	0	1
Droxidopa	0	4	6
Midodrine	0	0	4
Ampreloxetine	0	3	4
Pseudoephedrine	0	0	3
Trimethaphan	0	0	2
Nebivolol	0	0	2
Amlenetug	0	0	1
Bosentan	0	0	1
Eplerenone	0	0	1

Coming up

0phase 3 studies under way

7studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 7

Nov 2026Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension · Vanderbilt University Medical Center
Dec 2026Treatment of Supine Hypertension in Autonomic Failure (CPAP) · Vanderbilt University Medical Center
Dec 2026Natural History Study of Synucleinopathies · NYU Langone Health
Feb 2027[18F]F-DOPA Imaging in Patients With Autonomic Failure · Daniel Claassen
Mar 2027CPAP for the Treatment of Supine Hypertension · Vanderbilt University Medical Center
Jun 2027Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms · Vanderbilt University Medical Center
Aug 2027Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure · Vanderbilt University Medical Center

Who these studies take

Of the 9 Pure Autonomic Failure studies recruiting now, 2 (22%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.

Recruiting studies that take each age, of 9
Age	Women	Men
10	0 (0%)	0 (0%)
18	7 (78%)	7 (78%)
30	7 (78%)	7 (78%)
40	9 (100%)	9 (100%)
50	9 (100%)	9 (100%)
65	9 (100%)	9 (100%)
75	9 (100%)	9 (100%)
85	6 (67%)	6 (67%)

Across all 56 studies, recruiting or not: 11% stop at 75 or younger and 5% at 65; 2% take children; 0% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 13, 2026.

Stopped1

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic FailureTerminatedOct 23, 2026NCT02897063

Studies

Recruiting first, then most recently updated. Showing 50 of 56. Browse all 56 → or search them.