Acute Lung Injury clinical trials
The registry lists 382 studies for Acute Lung Injury across more than 10 countries. 73 are recruiting or about to start. 218 of them are mainly about Acute Lung Injury (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Peking Union Medical College Hospital (7) · Assistance Publique - Hôpitaux de Paris (7) · Southeast University, China (6) · Policlinico Hospital (6) · University Hospital, Ghent (5) · Medical University of Vienna (5) · GlaxoSmithKline (5) · National Heart, Lung, and Blood Institute (NHLBI) (5)
What is being tested here
Drugs under test in Acute Lung Injury studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Vilobelimab | 2 | 0 | 2 |
| NI-0101 | 2 | 0 | 2 |
| Bevacizumab | 2 | 0 | 2 |
| Oxygen | 1 | 1 | 3 |
| Lidocaine | 1 | 0 | 2 |
| Simvastatin | 1 | 0 | 2 |
| Baricitinib | 1 | 0 | 1 |
| Ondansetron | 1 | 1 | 1 |
| Ciprofol | 1 | 0 | 1 |
| Fluorine F 18 FAPI-74 | 1 | 1 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · JAK inhibitors 1 open · Statins 1 open · Corticosteroids 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation · Phase 3 · Shanghai University of Traditional Chinese Medicine
- Nov 2026Early Use of Airway Pressure Release Ventilation (APRV) in ARDS · Hospital Civil de Guadalajara
- Nov 2026A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome · Shanghai Zhongshan Hospital
- Dec 2026Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy. · University of Pennsylvania
- Dec 2026Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study) · Peking Union Medical College Hospital
- Dec 2026The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications · Yongtao Sun
- Dec 2026Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients · First Affiliated Hospital of Wannan Medical College
- Dec 2026Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS · XiaoJing Zou,MD
- Dec 2026EXTEND ARDS-J Esophageal Pressure Study · Sapporo Medical University
- Jan 2027Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS · HTIC, Inc
Who these studies take
Of the 45 Acute Lung Injury studies recruiting now, 25 (56%) set no upper age limit and 8 (18%) stop at 75 or younger. 6 (13%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 7 (16%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (4%) | 2 (4%) |
| 18 | 40 (89%) | 39 (87%) |
| 30 | 41 (91%) | 40 (89%) |
| 40 | 42 (93%) | 41 (91%) |
| 50 | 41 (91%) | 40 (89%) |
| 65 | 41 (91%) | 40 (89%) |
| 75 | 40 (89%) | 39 (87%) |
| 85 | 31 (69%) | 31 (69%) |
Across all 382 studies, recruiting or not: 23% stop at 75 or younger and 16% at 65; 18% take children; 1% are for women only and 1% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Acute Lung Injury studies take
Of 22 phase 2 interventional studies under Acute Lung Injury, half reached primary completion within 39 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 39 mo13–60 · 22 studies | — | — |
| Interventional, no phase | 15 mo7–34 · 52 studies | — | 15 mo7–34 · 51 studies |
| Observational | 18 mo8–47 · 46 studies | — | 18 mo8–47 · 41 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome)Nov 6, 2026NCT07823296
Newly registered2
- Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDSNov 2, 2026NCT07908368
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSOct 27, 2026NCT07898319
Studies
Recruiting first, then most recently updated. Showing 50 of 382. Browse all 382 → or search them.
- Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDSNot yet recruitingNCT07790133Not applicable1 country
- Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome)RecruitingNCT078232961 country
- Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDSRecruitingNCT079083681 country
- PirfenidoneVsPlacebo as Prophylaxis Against Acute Radiation-induced Lung Injury Following HFRT in Breast Cancer PatientsRecruitingNCT05704166Phase 21 country
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSNot yet recruitingNCT078983191 country
- Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT ImagingRecruitingNCT07613099Phase 31 country
- Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory FailureNot yet recruitingNCT07779642Phase 2
- The Effect of Catheter Size on the Efficacy of Ultralow-flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress SyndromeNot yet recruitingNCT07858136Not applicable1 country
- Safety and Efficacy Study of GKL-006RTU in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS)Not yet recruitingNCT07706855Phase 1/2
- Observational, Non-interventional Biomarker and Endotyping StudyRecruitingNCT076752651 country
- Early Use of Airway Pressure Release Ventilation (APRV) in ARDSRecruitingNCT04221737Not applicable1 country
- Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDSRecruitingNCT07449572Phase 11 country
- Safety and Performance of the Novalung Ultimate Kit and Xenios 2.0 During Stationary Use in Hospital and Ground-based Transport of Patients on Extracorporeal Life Support (ECLS)RecruitingNCT071566691 country
- The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung MechanicsRecruitingNCT07188038Not applicable1 country
- EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDSNot yet recruitingNCT072819111 country
- The Variable Ventilation Trial (Part A)Not yet recruitingNCT07791225Not applicable1 country
- Digital Early Warning System for Acute Lung Injury in Liver SurgeryRecruitingNCT070703621 country
- Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant RecipientsRecruitingNCT06476132Phase 22 countries
- Infants With Severe Acute Respiratory Distress Syndrome: The Prone TrialRecruitingNCT05002478Not applicable1 country
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: VilobelimabRecruitingNCT06701682Phase 21 country
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)RecruitingNCT06703073Phase 21 country
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: ParidiprubartRecruitingNCT06701669Phase 21 country
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: BevacizumabRecruitingNCT06701656Phase 21 country
- Anti-CD14 Treatment With IC14 in Hospitalized ARDS PatientsRecruitingNCT06513949Phase 21 country
- Outer Membrane Vesicle and Ferroptosis-Related Signatures in Sepsis-Associated Acute Lung Injury Caused by Extra-Pulmonary Hypervirulent Klebsiella PneumoniaeNot yet recruitingNCT07686887
- Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.RecruitingNCT07603310Not applicable1 country
- BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and RadiomicsRecruitingNCT076333661 country
- Effect of EIT-guided PEEP in ARDS PatientsRecruitingNCT06990477Not applicable3 countries
- Lung EIT Image Guide Ventilation in ARDSRecruitingNCT07309783Not applicable1 country
- Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological DistressNot yet recruitingNCT07634419Not applicable1 country
- Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)RecruitingNCT07307066Not applicable1 country
- Time-controlled Adaptive Ventilation (TCAV) Compared With Conventional Ventilation in Patients With Moderate-to-severe Acute Respiratory Distress Syndrome (ARDS) Secondary to Community-acquired PneumoniaNot yet recruitingNCT07679802Not applicable1 country
- A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress SyndromeRecruitingNCT07558538Early Phase 11 country
- Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.RecruitingNCT071250791 country
- Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance TomographyRecruitingNCT07623590Not applicable1 country
- EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory SupportNot yet recruitingNCT076172981 country
- Recovery of Physical Function After Critical Illness In Older AdultsRecruitingNCT072252571 country
- Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)Not yet recruitingNCT07567768Phase 2
- Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCTNot yet recruitingNCT07588217Phase 2/31 country
- RECOMMEND Platform TrialRecruitingNCT06526533Phase 31 country
- SWedish Intensive Care BiobankNot yet recruitingNCT07582601
- Clinical Decision Support Tool in PARDS Pilot StudyRecruitingNCT04068012Not applicable3 countries
- Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac SurgeryNot yet recruitingNCT07499154Phase 41 country
- ALI & Pulmonary HA Deposition After SAHRecruitingNCT066285311 country
- The Impact of Automatic Lung Recruitment Postoperative Pulmonary ComplicationsNot yet recruitingNCT07477951Not applicable1 country
- Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress SyndromeEnrolling by invitationNCT073803731 country
- Prone Position Assessed by 3D EITRecruitingNCT070839731 country
- This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft DysfunctionRecruitingNCT06853223Phase 21 country
- The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in MartiniqueNot yet recruitingNCT07351435
- Albumin and Prognosis of Severely Patients BurnsRecruitingNCT042640651 country