An observational study in Acute Lung Injury(ALI), Liver Cirrhosis and ARDS, Human, sponsored by Beijing Tsinghua Chang Gung Hospital. Recruiting at 4 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-17.
Sponsored by Beijing Tsinghua Chang Gung Hospital · Observational
Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →
Among 59 studies in Acute Lung Injury with a site in China — 20 open to participants now, 20 under way, 1 of them phase 3. Acute Lung Injury · China.
Among the 59 studies in Acute Lung Injury with a site in China, this one is the 2nd largest by planned enrollment of the 28 observational ones that give a count, is one of 8 that started in 2024, is one of 28 observational ones, reaches primary completion later than 12 of the 19 other live ones, and was the 45th registered.
382 studies on the registry are indexed under Acute Lung Injury; 73 are open to participants now.
Browse Acute Lung Injury studies →20 of the 59 studies in Acute Lung Injury with a site in China are open now. Recruiting first, the newest first:
Shanghai Zhongshan Hospital · Sites in China
Ages 18–80
Peking Union Medical College Hospital · Sites in China
Ages 18+
Southeast University, China · Sites in China, Korea, Republic of, Taiwan
Ages 19–90
Peking Union Medical College Hospital · Sites in China
Ages 18–75
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Sites in China
Ages 18–80
A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →
Of the 45 Acute Lung Injury studies recruiting now, 25 (56%) set no upper age limit and 8 (18%) stop at 75 or younger; 6 take children under 18; 7 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
59 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 6 · Phase 2 7 · Phase 3 1 · Phase 4 1
First in 2006; this study’s year is marked. 8 started in 2024.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 3,000 is above the median of 100 across 131 observational studies indexed under Acute Lung Injury.
Median enrollment 60 across the 31 interventional studies, 103 across the 28 observational. Of the 20 that completed or were terminated, 3 (15%) have results posted.
This tab as a report to print or save as PDF → With an account.
2 of 59 have an industry lead sponsor. The 10 most frequent:
Beijing Tsinghua Chang Gung Hospital is the lead sponsor of 110 studies on the registry; 58 are open to participants now.
Beijing Tsinghua Chang Gung Hospital has 1 study filed under Acute Lung Injury — fewer than ten, so there is no comparison to draw.
8 of the studies in Acute Lung Injury with a site in China that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07342205Phase 3Shanghai University of Traditional Chinese MedicineA Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation | 2027-06 |
| NCT07558538Shanghai Zhongshan HospitalA Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome | 2026-11-30 |
| NCT07307066Peking Union Medical College HospitalReal-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study) | 2026-12-30 |
| NCT07477951Yongtao SunThe Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications | 2026-12-31 |
| NCT06696638XiaoJing Zou,MDPhysiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS | 2026-12-31 |
Add all 8 to your calendar (.ics) → With an account.
Among the 59 studies in Acute Lung Injury with a site in China, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions. This model will enable early prediction of acute lung injury (ALI) in patients undergoing major liver surgery. The research will create a digital early-warning system for ALI, thereby supporting clinical diagnosis and treatment decisions. This, in turn, should help reduce the incidence and mortality rates associated with ALI.
This study will leverage parameters to predict ALI in patients undergoing major liver surgery. Specifically, the research will collect data from preoperative, intraoperative, and postoperative phases. Machine learning algorithms-including logistic regression, random forest, support vector machines (SVM), and neural networks-will be used to develop and validate the prediction model. Model performance will be evaluated using metrics such as accuracy, sensitivity, specificity, and the receiver operating characteristic (ROC) curve. The ultimate objective is to develop a highly accurate and interpretable model that can be integrated into a digital early-warning system for clinical application.
Inclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Consecutive eligible adults who underwent major hepatobiliary or pancreatic surgery or liver transplantation at three independent external centres: Peking University International Hospital (WYA), Southwest Hospital of Army Medical University (WYB), and Huangdao District People's Hospital of Qingdao (WYC). The frozen full perioperative M3 model developed at BTCH was applied using the same predictor definitions, imputation rules, model parameters, and classification threshold, without centre-specific model fitting or recalibration. Centre-specific and pooled validation analyses were performed. This was a retrospective observational cohort; no intervention was assigned and routine clinical care was not altered.
Consecutive eligible adults who underwent major hepatobiliary or pancreatic surgery or liver transplantation at Beijing Tsinghua Changgung Hospital (BTCH) between October 16, 2015, and December 24, 2025. The earliest 70% formed the development cohort and the most recent 30% formed the temporal-validation cohort. Model development was confined to the development cohort, and the frozen models were evaluated in the temporal-validation cohort. This was a retrospective observational study; no intervention was assigned and routine clinical care was not altered.
Occurrence of ALI within 7 Days after Surgery
Berlin Definition: 1. Onset: Acute exacerbation of known injury or new/worsening respiratory symptoms within 1 week. 2. Chest Imaging (X-ray or CT): Bilateral pulmonary shadows not fully explained by exudation, atelectasis, or nodules. 3. Pulmonary Edema Etiology: Respiratory failure not fully attributed to heart failure or fluid overload; if no related risk factors, objective tests (e.g., Doppler echocardiography) are needed to exclude hydrostatic pulmonary edema. 4. Oxygenation Levels: Mild - With CPAP/PEEP \>5 cmH2O, 200 mmHg \< PaO2/FiO2 \< 300 mmHg; Moderate - With CPAP/PEEP \>5 cmH2O, 100 mmHg \< PaO2/FiO2 \< 200 mmHg; Severe - With CPAP/PEEP \>5 cmH2O, PaO2/FiO2 \< 100 mmHg.
Time frame: Perioperative period (Perioperative): Refers to the entire process from the determination of surgical treatment to postoperative rehabilitation (e.g., from 1 day before surgery to 7 days after surgery).
Plan to share: No
Started Nov 2024 (actual). Primary completion is estimated for Jun 2027, 31 months after the start.
Of 41 non-industry observational studies under Acute Lung Injury, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 47. This study's planned 31 months is above that.
Counting every sponsor, half of 46 studies reached it within 18 months; a quarter within 8 and three quarters within 47.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Beijing Tsinghua Chang Gung Hospital →