Lung Injury clinical trials
The registry lists 114 studies for Lung Injury across more than 10 countries. 33 are recruiting or about to start. 47 of them are mainly about Lung Injury (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 6 narrower conditions too, such as Acute Lung Injury: 1,016 studies, 238 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University Health Network, Toronto (4) · GlaxoSmithKline (3) · University of California, San Diego (2) · Beth Israel Deaconess Medical Center (2) · Belfast Health and Social Care Trust (2) · National Taiwan University Hospital (2) · Assiut University (2) · Ain Shams University (2)
What is being tested here
Drugs under test in Lung Injury studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Budesonide | 2 | 1 | 2 |
| Sevoflurane | 1 | 0 | 3 |
| Midazolam | 1 | 0 | 2 |
| Dexmedetomidine | 1 | 0 | 2 |
| Lidocaine | 1 | 0 | 1 |
| Poractant alfa | 1 | 1 | 1 |
| Fentanyl | 1 | 0 | 1 |
| Propofol | 1 | 0 | 1 |
| Cisatracurium | 1 | 0 | 1 |
| Oxygen | 1 | 0 | 1 |
Drug classes tested here Corticosteroids 2 open · Inhaled anesthetics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7, phase 3 first
- Dec 2026Pirfenidone Capsules in the Treatment of Radiation-induced Lung Injury With or Without Immune Pneumonia · Phase 3 · Beijing Continent Pharmaceutical Co, Ltd.
- Nov 2026Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). · Murdoch Childrens Research Institute
- Dec 2026Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB) · Sophia Koutsogiannaki
- Dec 2026Open Lung Protective Extubation Following General Anesthesia · Centre hospitalier de l'Université de Montréal (CHUM)
- Dec 2026Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients · Instituto Nacional de Cancerologia de Mexico
- Dec 2026Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath · ChromX Health
- Dec 2026Efficacy and Safety of Baricitinib in the Post-intracerebral Hemorrhage Pulmonary Injury · Tianjin Medical University General Hospital
Who these studies take
Of the 25 Lung Injury studies recruiting now, 12 (48%) set no upper age limit and 8 (32%) stop at 75 or younger. 3 (12%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 19 (76%) | 19 (76%) |
| 30 | 19 (76%) | 19 (76%) |
| 40 | 19 (76%) | 19 (76%) |
| 50 | 18 (72%) | 18 (72%) |
| 65 | 21 (84%) | 21 (84%) |
| 75 | 21 (84%) | 21 (84%) |
| 85 | 16 (64%) | 16 (64%) |
Across all 114 studies, recruiting or not: 33% stop at 75 or younger and 26% at 65; 22% take children; 0% are for women only and 2% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lung Injury studies take
Of 28 interventional studies with no phase under Lung Injury, half reached primary completion within 38 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 38 mo17–69 · 28 studies | — | — |
| Observational | 27 mo11–101 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical TrialTerminatedOct 30, 2026NCT05509088
Studies
Recruiting first, then most recently updated. Showing 50 of 114. Browse all 114 → or search them.
- Personalized Ventilator Settings for Patients on ECMOEnrolling by invitationNCT07673250Not applicable1 country
- Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature NeonatesRecruitingNCT06849596Not applicable3 countries
- Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna TrialRecruitingNCT06686251Not applicable1 country
- Impact of Intraoperative Oxygenation Practices on Patient OutcomesRecruitingNCT07224243Not applicable1 country
- Respiratory Variability and Postoperative Complications During Thoracic Lung Resection.RecruitingNCT06133777Not applicable1 country
- Open Lung Protective Extubation Following General AnesthesiaRecruitingNCT06296173Not applicable1 country
- Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung InjuryRecruitingNCT07086755Phase 2/31 country
- Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in InfantsRecruitingNCT049894391 country
- Exhaled Breath Condensate Analysis in Mechanically Ventilated PatientsRecruitingNCT061899241 country
- Functional Residual Capacity and Alveolar Recruitment in Single-lung Ventilation: a Randomized StudyNot yet recruitingNCT06446544Not applicable1 country
- Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing SurgeryNot yet recruitingNCT07601256Not applicable1 country
- Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)RecruitingNCT042960711 country
- Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPDNot yet recruitingNCT053814151 country
- Pirfenidone Capsules in the Treatment of Radiation-induced Lung Injury With or Without Immune PneumoniaRecruitingNCT07388680Phase 2/31 country
- Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer PatientsRecruitingNCT03803787Phase 21 country
- Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac SurgeryNot yet recruitingNCT07499154Phase 41 country
- Study on Safety and Efficacy of UCB-MNCs for Radiation-induced Lung InjuryNot yet recruitingNCT07177456Early Phase 1
- Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVARecruitingNCT05689476Not applicable1 country
- The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled TrialRecruitingNCT06203405Not applicable1 country
- Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled BreathRecruitingNCT065284181 country
- Feasibility of Reducing Respiratory Drive Using the Through-flow SystemRecruitingNCT05642832Not applicable1 country
- Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory FailureRecruitingNCT022999211 country
- The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe ResectionRecruitingNCT06514729Not applicable1 country
- Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term OutcomesRecruitingNCT058577741 country
- Stem Cell Treatment for Lung Injury Caused by Major Infectious DiseasesRecruitingNCT06416709Phase 1/21 country
- Vaping Adverse Lung and Heart Events CohortRecruitingNCT062915971 country
- Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo ModelRecruitingNCT05414370Not applicable1 country
- Effect of Human Umbilical Cord-derived Mesenchymal Stem Cells on Non-cardiac Surgery-induced Lung InjuryRecruitingNCT04996966Phase 11 country
- Polypropylene vs Polyglactin in Suturing of the LungNot yet recruitingNCT06115447
- Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly PatientsRecruitingNCT06021249Not applicable1 country
- Dead Mesenchymal Stem Cells for Radiation Lung InjuryRecruitingNCT06021067Phase 1/21 country
- Perioperative Database of Chinese Elderly PatientsRecruitingNCT049115301 country
- Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia.Not yet recruitingNCT04862377Phase 3
- Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical TrialTerminatedNCT05509088Not applicable1 country
- Efficacy and Safety of Baricitinib in the Post-intracerebral Hemorrhage Pulmonary InjuryActive, not recruitingNCT06548802Phase 1/21 country
- Pragmatic Research on Diuretic Management in Early BPD PilotCompletedNCT05898022Phase 41 country
- Inhalational Sedation and Mechanical PowerCompletedNCT05559970Not applicable1 country
- Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)CompletedNCT02166853Phase 41 country
- Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).Active, not recruitingNCT04372953Not applicable7 countries
- Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal CancerCompletedNCT07385898Not applicable1 country
- Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic IrradiationTerminatedNCT034311291 country
- A Study About Safety and Efficacy of Pirfenidone to Treat Grade 2 or Grade3 Radiation-induced Lung Injury.CompletedNCT03902509Phase 21 country
- Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung InjuryCompletedNCT053167271 country
- Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory FailureCompletedNCT05465083Not applicable1 country
- Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory WorkCompletedNCT03612583Phase 11 country
- CLBS119 for Repair of COVID-19 Induced Pulmonary DamageWithdrawnNCT04522817Phase 11 country
- Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)CompletedNCT047945431 country
- Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma PatientsCompletedNCT050542701 country
- Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing ComplicationsCompletedNCT063759801 country
- Inhibition of Plasma Kallikrein as a New Therapy for Lung InjuryActive, not recruitingNCT04848272Phase 11 country