Drug
Sacubitril clinical trials
Also written AHU377.
- studies test it
- 46
- open now
- 11
- in phase 3
- 14
- first study started
- 2007
Keep track of what changes. Save the sacubitril studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Studies by the year they started
46 studies that test it; most in 2019 (6)
| Year | Studies |
|---|---|
| 2007 | 1 |
| 2011 | 1 |
| 2016 | 3 |
| 2017 | 3 |
| 2018 | 3 |
| 2019 | 6 |
| 2020 | 6 |
| 2021 | 5 |
| 2022 | 4 |
| 2023 | 4 |
| 2024 | 3 |
| 2025 | 5 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 1
- Phase 2
- 9
- Phase 3
- 14
- Phase 4
- 18
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 10 · Other 36
Novartis Pharmaceuticals (8) · Shenzhen Salubris Pharmaceuticals Co., Ltd. (2) · RenJi Hospital (2) · National Heart Institute, Egypt (1) · University Clinical Hospital Mostar (1) · Torbjorn Omland (1) · St. Josefs-Hospital Wiesbaden GmbH (1) · University of Virginia (1)
Often tested with
Tested in the same studies.
Valsartan (42) · Losartan (3) · Amlodipine (2) · Sacubitril valsartan sodium hydrate (2) · Sacubitril valsartan (2) · Bisoprolol (2) · Nebivolol (1) · Carvedilol (1)
Studies
Open first, then newest update. How each study uses sacubitril is read from its arms, and is right about nine times in ten.
Testing it · 46
- Manganese-enhanced Magnetic Resonance Imaging in Takotsubo CardiomyopathyRecruitingNot applicableUniversity of EdinburghNCT07491718Written as sacubitril/ valsartan
- The Effect of Sacubitril/Valsartan Versus Ramipril on Left Ventricular Function and Remodeling in Patients With Ischemic Heart Failure With Mid-range Ejection FractionRecruitingPhase 3John Paul II Hospital, KrakowNCT05508035Written as Sacubitril / Valsartan
- Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural TanzaniaRecruitingPhase 4Martin RohacekNCT06704633Written as Sacubitril / Valsartan Oral Tablet
- Sacubitril/Allisartan for Hypertensive Patients With Overweight or ObesityNot yet recruitingPhase 4Jing LiuNCT07241338Written as sacubitril/allisartan
- Enhancing the Natriuretic Peptide System in HFpEFEnrolling by invitationPhase 1/2Horng ChenNCT05279742Written as Sacubitril/Valsartan
- Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection FractionRecruitingNot applicableKafrelsheikh UniversityNCT07192341Written as Sacubitril/Valsartan
- Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery DiseaseRecruitingPhase 4China National Center for Cardiovascular DiseasesNCT06917664Written as sacubitril/valsartan
- Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection FractionNot yet recruitingPhase 3Puerta de Hierro University HospitalNCT06712030Written as Sacubitril / Valsartan
- Sacubitril/Valsartan Treats Patients With Essential Hypertension and Type 2 Diabetic NephropathyNot yet recruitingPhase 4Sichuan Academy of Medical SciencesNCT06501651Written as Sacubitril/Valsartan
- Diuretics vs. Afterload Reduction for Treatment of HeartLogic AlertsRecruitingPhase 4Heart Center Research, LLCNCT06218199Written as sacubitril/valsartan
- Determination of Drug Levels for Pharmacotherapy of Heart FailureNot yet recruitingPhase 4University Hospital OstravaNCT06035978Written as Valsartan and Sacubitril
- Glucagon-like Peptide-1 Metabolism and Acute Neprilysin InhibitionWithdrawnPhase 3University of PennsylvaniaNCT03508739Written as Sacubitril/Valsartan 200mg (blinded)
- Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart FailureCompletedPhase 2/3National Heart Institute, EgyptNCT07023016Written as Sacubitril / Valsartan
- Assess Sacubitril/Allisartan and Amlodipine in Patients With Essential Hypertension Uncontrolled With Sacubitril/AllisartanCompletedPhase 3Shenzhen Salubris Pharmaceuticals Co., Ltd.NCT07704697Written as Experimental: Sacubitril/Allisartan and Amlodipine Group
- Assess Sacubitril/Allisartan and Amlodipine in Patients With Essential Hypertension Uncontrolled With AmlodipineCompletedPhase 3Shenzhen Salubris Pharmaceuticals Co., Ltd.NCT07704684Written as Experimental: Sacubitril/Allisartan and Amlodipine Group
- The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEFCompletedPhase 4University Clinical Hospital MostarNCT07417215Written as Sacubitril / Valsartan
- Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCCCompletedPhase 4Novartis PharmaceuticalsNCT04023227Written as Sacubitril/valsartan
- A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 StudyCompletedPhase 3Novartis PharmaceuticalsNCT06149104Written as sacubitril/valsartan
- Open-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HFCompletedPhase 3Novartis PharmaceuticalsNCT03785405Written as sacubitril/valsartan
- Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)CompletedPhase 3Novartis PharmaceuticalsNCT03988634Written as sacubitril/valsartan
See all 46 studies that test sacubitril →
Given in every arm · 4 — sacubitril is usual care beside what is tested
- Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot StudyRecruitingPhase 4Kyungsub SongNCT07572032Written as Sacubitril / Valsartan
- Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG TrialRecruitingPhase 1Khawaja Danish AliNCT07444398Written as Sacubitril / Valsartan
- Multimodal Analgesia for CholecystectomyCompletedPhase 3Gangnam Severance HospitalNCT04788654Written as Celebrex, acetaminophen, and dexamethasone
- Pulmonary Artery Pressure Reduction With ENTresto (Sacubitril/Valsartan)TerminatedPhase 4Brigham and Women's HospitalNCT02788656Written as sacubitril/valsartan
As the comparator · 4 — what is tested is compared with sacubitril
- QR12000 Compound Tablets in Patients with Moderate to Severe Essential HypertensionNot yet recruitingPhase 3Wuhan Createrna Science and Technology Co., LtdNCT06716970Written as Sacubitril/valsartan 200mg
- A Phase II Clinical Study of QR12000 Compound Tablets in Patients With Moderate to Severe Essential HypertensionCompletedPhase 2Wuhan Createrna Science and Technology Co., LtdNCT07700875Written as Sacubitril / valsartan 200 mg
- A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart FailureTerminatedPhase 2Novartis PharmaceuticalsNCT06142383Written as Sacubitril/valsartan
- The Best Treatment Strategy: Surgical vs Pharmacological to Close the Ductus Arteriosus Persistent in Preterm InfantsStatus unknownPhase 2Hospital General Naval de Alta Especialidad - Escuela Medico NavalNCT02602054Written as Control group
Codes
What other systems call sacubitril · ClinicalTrials.gg INT001624
- MeSH (NLM) C000717211sacubitrilOne source NLM
- UNII (FDA) 17ERJ0MKGISACUBITRILConfirmed FDA, NLM, Wikidata
- RxNorm 1656328Confirmed FDA, Wikidata
- Wikidata Q17811448sacubitrilConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C152281SacubitrilOne source FDA
- DrugBank DB09292One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000717211 | sacubitril | One source NLM |
| UNII (FDA) | 17ERJ0MKGI | SACUBITRIL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1656328 | — | Confirmed FDA, Wikidata |
| Wikidata | Q17811448 | sacubitril | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C152281 | Sacubitril | One source FDA |
| DrugBank | DB09292 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.