Chagas Disease clinical trials
The registry lists 73 studies for Chagas Disease across more than 10 countries. 5 are recruiting or about to start. 54 of them are mainly about Chagas Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Chagas Cardiomyopathy too: 80 studies, 6 open.
Get an email when these change. Save the Chagas Disease studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Bayer (7) · Drugs for Neglected Diseases (7) · Hospital de Niños R. Gutierrez de Buenos Aires (6) · Hospital Sao Rafael (6) · University of Sao Paulo General Hospital (5) · Novartis Pharmaceuticals (3) · Hospital Universitari Vall d'Hebron Research Institute (2) · Evandro Chagas Institute of Clinical Research (2)
What is being tested here
Drugs under test in Chagas Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2, phase 3 first
- Aug 2027Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease · Phase 3 · Insud Pharma
- Jul 2027A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. · Novartis Pharmaceuticals
Who these studies take
Of the 3 Chagas Disease studies recruiting now, 1 (33%) set no upper age limit and 2 (67%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 3 (100%) | 3 (100%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 1 (33%) | 1 (33%) |
| 75 | 1 (33%) | 1 (33%) |
| 85 | 1 (33%) | 1 (33%) |
Across all 73 studies, recruiting or not: 67% stop at 75 or younger and 51% at 65; 16% take children; 7% are for women only and 3% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 73. Browse all 73 → or search them.
- A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.RecruitingNCT06632600Phase 24 countries
- Assessment of the Risk of Zoonotic Infections in Prisons in French GuianaNot yet recruitingNCT078087751 country
- An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's HealthNot yet recruitingNCT0547795312 countries
- Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.RecruitingNCT04853758Phase 31 country
- Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas DiseaseRecruitingNCT04897516Phase 31 country
- A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy SubjectsCompletedNCT07809919Phase 11 country
- University-Based Chagas Testing in Salta Province, ArgentinaCompletedNCT070333251 country
- Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCCCompletedNCT04023227Phase 44 countries
- First-in-Human Trial of Oral AN2-502998CompletedNCT07024589Phase 11 country
- Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas DiseaseActive, not recruitingNCT04024163Phase 33 countries
- Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive AgeCompletedNCT03672487Phase 32 countries
- Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas DiseaseCompletedNCT04239144Not applicable1 country
- Delivering a Multi-disease Screening Tool to Migrant PopulationsCompletedNCT05868005Not applicable1 country
- Short Benznidazole Regimen for Chronic Phase Chagas Disease PatientsWithdrawnNCT06339710Phase 31 country
- Cardiac Mechanics by Speckle Tracking As a Prognostic Predictor in Patients with Chagas CardiomyopathyCompletedNCT068067221 country
- Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas DiseaseTerminatedNCT04984616Phase 21 country
- A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma CruziCompletedNCT02625974Phase 33 countries
- New Therapies and Biomarkers for Chagas InfectionCompletedNCT03981523Phase 21 country
- SBRT in Chagas Disease Ventricular TachycardiaActive, not recruitingNCT04984265Phase 1/21 country
- Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.CompletedNCT03191162Phase 24 countries
- Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)Status unknownNCT01650792Phase 41 country
- Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas DiseasesStatus unknownNCT040843791 country
- Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease TreatmentStatus unknownNCT042741011 country
- Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Humans by a Bug, Using Information From Patient Medical Records in ArgentinaCompletedNCT037843911 country
- Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas DiseaseCompletedNCT023270521 country
- Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits StudyCompletedNCT03334838Phase 11 country
- Oral Fexinidazole Dosing Regimens for the Treatment of Adults With Chronic Indeterminate Chagas DiseaseCompletedNCT03587766Phase 21 country
- Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas CardiomyopathyCompletedNCT02154269Phase 21 country
- Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evaluation in Chagas Disease Treated ChildrenCompletedNCT040904891 country
- BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' DiseaseCompletedNCT00123916Phase 35 countries
- Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mgCompletedNCT03350295Phase 11 country
- Pharmacokinetic Drug-Drug Interaction StudyCompletedNCT03892213Phase 11 country
- Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on ElectrocardiogramCompletedNCT004537001 country
- Colchicine for Patients With Chagas´ Disease( B1 Stage)Status unknownNCT03704181Phase 21 country
- A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267)CompletedNCT01377480Phase 2
- Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas DiseaseCompletedNCT01678599Phase 41 country
- Population Pharmacokinetics Study of Benznidazole in Children With Chagas'DiseaseCompletedNCT01549236Phase 41 country
- Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic PresentationCompletedNCT031890561 country
- Improving Blood Safety and HIV Testing in BrazilCompletedNCT01681420Not applicable1 country
- BENDITA BEnznidazole New Doses Improved Treatment and AssociationsStatus unknownNCT03378661Phase 21 country
- Galectin-3 as a Biomarker in Patients With Chagas DiseaseCompletedNCT018428541 country
- Physical Exercise Program in Chronic Chagas Heart DiseaseCompletedNCT02517632Phase 31 country
- CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY)Status unknownNCT02369978Phase 2/31 country
- A Trial Testing Amiodarone in Chagas CardiomiopathyStatus unknownNCT03193749Phase 31 country
- Congenital Transmission of Lineages I and II of Trypanosoma CruziCompletedNCT017879685 countries
- Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' PatientsCompletedNCT02606864Phase 11 country
- Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas DiseaseTerminatedNCT01539161Phase 42 countries
- Effects of Omega-3 Supplementation on the Cytokine and Lipid Profiles in Patients With Chronic Chagas CardiomyopathyCompletedNCT01863576Early Phase 11 country
- New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas DiseaseCompletedNCT017553771 country
- Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United StatesCompletedNCT00005455