Heart Failure, Systolic clinical trials

The registry lists 230 studies for Heart Failure, Systolic across more than 10 countries. 51 are recruiting or about to start. 155 of them are mainly about Heart Failure, Systolic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed: 98
Status unknown: 39
Recruiting: 29
Terminated: 19
Not yet recruiting: 16
Withdrawn: 11

Phase

Phase 4: 29
Phase 2: 24
Phase 3: 19
Phase 1: 12
Early Phase 1: 2

Where

United States: 83
United Kingdom: 16
Denmark: 15
China: 11
Germany: 11
Canada: 9

Who runs them

Novartis Pharmaceuticals (6) · University of Leeds (5) · Virginia Commonwealth University (5) · University of Colorado, Denver (4) · University of Virginia (3) · University of Aarhus (3) · Oslo University Hospital (3) · Imperial College London (3)

What is being tested here

Drugs under test in Heart Failure, Systolic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Digoxin	2	0	2
Ferric carboxymaltose	1	2	4
Dapagliflozin	1	1	3
Bisoprolol	1	0	2
Eplerenone	1	0	1
Spironolactone	1	0	1
Tirzepatide	1	1	1
Sucrosomial iron	1	0	1
Vitamin D	1	0	1
Selenium	1	1	1

Drug classes tested here Beta blockers 2 open · SGLT2 inhibitors 1 open · Angiotensin receptor blockers (ARBs) 6

Coming up

4phase 3 studies under way

13studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Jun 2027Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity · Phase 3 · Shahid Beheshti University of Medical Sciences
Dec 2026Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells · BioCardia, Inc.
Dec 2026Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status · University of Virginia
Dec 2026Personalized IoT-based Physical Activity Monitoring System for Heart Failure Patients · Abant Izzet Baysal University
Dec 2026Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery. · Karlstad Central Hospital
Jan 2027A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure · Yale University
Feb 2027Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) · Weill Medical College of Cornell University
Feb 2027Neuromodulation of Inflammation and Endothelial Function · University of Oklahoma
Mar 2027Heart Failure and Postoperative Outcome in Surgery - a National Registry Study · Umeå University
Jun 2027Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany · AstraZeneca

Who these studies take

Of the 29 Heart Failure, Systolic studies recruiting now, 19 (66%) set no upper age limit and 2 (7%) stop at 75 or younger. 2 (7%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (3%) take healthy volunteers.

Recruiting studies that take each age, of 29
Age	Women	Men
10	2 (7%)	2 (7%)
18	27 (93%)	27 (93%)
30	28 (97%)	28 (97%)
40	28 (97%)	28 (97%)
50	28 (97%)	28 (97%)
65	29 (100%)	29 (100%)
75	28 (97%)	28 (97%)
85	24 (83%)	24 (83%)

Across all 230 studies, recruiting or not: 8% stop at 75 or younger and 1% at 65; 4% take children; 1% are for women only and 1% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Heart Failure, Systolic studies take

Of 56 interventional studies with no phase under Heart Failure, Systolic, half reached primary completion within 30 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	30 mo16–50 · 56 studies	—	27 mo13–46 · 52 studies
Observational	37 mo21–53 · 27 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Newly registered1

High-Intensity Interval Versus Aerobic Training for Patient-Reported Outcomes in Women With Heart Failure.Nov 9, 2026NCT07925515

Studies

Recruiting first, then most recently updated. Showing 50 of 230. Browse all 230 → or search them.