Hypercholesterolemia clinical trials
The registry lists 1,238 studies for Hypercholesterolemia across more than 10 countries. 110 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-24.
Status
- Completed
- 922
- Status unknown
- 83
- Recruiting
- 69
- Terminated
- 63
- Active, not recruiting
- 32
- Not yet recruiting
- 31
Phase
- Phase 3
- 307
- Phase 2
- 161
- Phase 4
- 142
- Phase 1
- 110
- Early Phase 1
- 9
Where
- United States
- 371
- Canada
- 142
- Netherlands
- 95
- Germany
- 84
- Italy
- 83
- United Kingdom
- 78
Who runs them
Organon and Co (91) · AstraZeneca (61) · Merck Sharp & Dohme LLC (38) · Sanofi (34) · National Heart, Lung, and Blood Institute (NHLBI) (32) · Novartis Pharmaceuticals (26) · Amgen (22) · Regeneron Pharmaceuticals (20)
Studies
Recruiting first, then most recently updated. Showing 50 of 1,238 — search for more.
- A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular DiseaseNot yet recruitingNCT07839936Phase 21 country
- Causes and Natural History of DyslipidemiasRecruitingNCT003537821 country
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular InterventionRecruitingNCT06909565Phase 41 country
- A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical AtheromaNot yet recruitingNCT07803679Phase 4
- A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)RecruitingNCT07428473Phase 12 countries
- A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular EventsNot yet recruitingNCT07474649Phase 33 countries
- A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory DyslipidemiasRecruitingNCT07491172Phase 14 countries
- A Clinical Study of Enlicitide (MK-0616) in Adults With Hyperlipidemia in India (MK-0616-038)Not yet recruitingNCT07821944Phase 3
- A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.RecruitingNCT07619131Phase 311 countries
- Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD TrialNot yet recruitingNCT07382414Not applicable1 country
- Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOHRecruitingNCT07799961Not applicable1 country
- Berberol P for Mild-to-Moderate HypercholesterolaemiaNot yet recruitingNCT07789366Not applicable1 country
- An Observational Study to Evaluate Treatment Patterns in High, Very High and Extreme Cardiovascular Risk Patients With Hypercholesterolemia, Including Familial HypercholesterolemiaNot yet recruitingNCT07606118
- A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant HypercholesterolemiaRecruitingNCT07610278Phase 21 country
- RCT for the Chinese Medicine in Treating HypercholesterolemiaNot yet recruitingNCT06700408Phase 2
- Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FHEnrolling by invitationNCT07102511Phase 36 countries
- Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial HypercholesterolemiaRecruitingNCT06597006Phase 311 countries
- A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have HypercholesterolemiaRecruitingNCT07477704Phase 21 country
- Phase 1b Study of VERVE-201 in Patients With Refractory HyperlipidemiaRecruitingNCT06451770Phase 16 countries
- Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" FoodRecruitingNCT06988462Not applicable1 country
- A Post-Marketing Clinical Trial of Pemafibrate in Patients ｗith Hypercholesterolemia and Inadequate Response to StatinsRecruitingNCT07634484Phase 41 country
- Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer SurvivorsEnrolling by invitationNCT06834204Not applicable1 country
- An Efficacy and Safety Study of Akkermansia Muciniphila AKM Lab-01 in HypercholesterolaemiaRecruitingNCT06974266Not applicable1 country
- Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVDRecruitingNCT07524101Not applicable1 country
- A Study Of SHR-1918 In Participants With Hypercholesterolemia With Inadequate Lipid Control on Statins Plus PCSK9 InhibitorsRecruitingNCT07404553Phase 2/31 country
- Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 DaysRecruitingNCT07614958Phase 31 country
- Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary PreventionRecruitingNCT07581808Phase 41 country
- A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Rosuvastatin on LDL-C in Patients With HypercholesterolaemiaNot yet recruitingNCT07619118Phase 3
- Improving Lipid Optimization Quality and Treatment Options in ASCVDEnrolling by invitationNCT06960655Not applicable1 country
- Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans StudyNot yet recruitingNCT07592858Phase 21 country
- Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial HypercholesterolemiaRecruitingNCT06597019Phase 323 countries
- Virtual Lifestyle Intervention for Weight Management and Cardiovascular HealEnrolling by invitationNCT07572721Not applicable1 country
- Vascular Intervention Strategies Trial for Alzheimer'sNot yet recruitingNCT07447206Phase 21 country
- Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor ProfileRecruitingNCT07514663Not applicable1 country
- Screening for Cardiac and Cardiac-associated Pathology Using Single-channel ElectrocardiogramNot yet recruitingNCT07396792
- Pharmacogenomic Informed Statin PrescribingRecruitingNCT06568601Not applicable1 country
- Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary SyndromeNot yet recruitingNCT07508254Phase 41 country
- Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular DiseaseEnrolling by invitationNCT061123272 countries
- Phase 1a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RN5681 in Healthy VolunteersRecruitingNCT07347678Phase 11 country
- Mechanism of Ketogenic Diet-Induced HypercholesterolemiaRecruitingNCT06894004Not applicable1 country
- Real World Adherence of PCSK9 Targeted TherapyNot yet recruitingNCT07468500
- Multicomponent Intervention Study- Blood Donors With High CholesterolRecruitingNCT05693701Not applicable1 country
- Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders TrialRecruitingNCT06488105Phase 21 country
- Screening for Familial Hypercholesterolemia in ChildrenRecruitingNCT06555120Not applicable1 country
- Investigating The Potential Of A Hay-Aged Cheese To Reduce Cholesterol As Mediated By Changes In The Gut MicrobiomeRecruitingNCT07351175Not applicable1 country
- DNV001 Injection in Patients With HypercholesterolemiaNot yet recruitingNCT07391722Phase 2
- Cobas® Lumira Collection of Venous and Capillary Blood Samples for the Research, Optimization and Calibration of New Diagnostic DevicesNot yet recruitingNCT07378514
- Pharmacy-led Transitions of Care Intervention to Improve Medication AdherenceRecruitingNCT06374277Not applicable1 country
- Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals With Prediabetes and Diabetes MellitusNot yet recruitingNCT07373392Not applicable1 country
- Evaluation of Adherence, Persistence and Efficacy of Treatment With Alirocumab 300mg in ItalyRecruitingNCT073752251 country