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Hypercholesterolemia clinical trials

The registry lists 1,175 studies for Hypercholesterolemia across more than 10 countries. 93 are recruiting or about to start. 819 of them are mainly about Hypercholesterolemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

ClinicalTrials.gov finds 1,489 studies for Hypercholesterolemia. How that becomes 1,175 here

This page counts the studies the registry files under Hypercholesterolemia, and those it files under no condition that list Hypercholesterolemiathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 1,489Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −204List Hypercholesterolemia as a condition, but the registry did not file them under itMost often written as “Familial Hypercholesterolemia” (79), “Homozygous Familial Hypercholesterolemia” (33), and “Hypercholesterolemia, Familial” (24). The registry filed 21 of them under no condition at all, and the others under other conditions only, most often Hyperlipoproteinemia Type II (129) and Homozygous Familial Hypercholesterolemia (52).
  3. −110Match it another way57 name it in the title, 14 in a keyword, and 39 by a synonym or other text the search reads.
  4. 1,175The count on this page42 of them list Hypercholesterolemia in their own words; the registry filed them under no condition.

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Status

Completed
896
Status unknown
68
Terminated
62
Recruiting
55
Active, not recruiting
31
Not yet recruiting
29

Phase

Phase 3
294
Phase 4
152
Phase 2
145
Phase 1
111
Early Phase 1
8

Where

United States
379
Canada
124
Germany
81
Netherlands
81
Italy
81
United Kingdom
80

Who runs them

Organon and Co (91) · AstraZeneca (59) · Sanofi (37) · Amgen (35) · National Heart, Lung, and Blood Institute (NHLBI) (30) · Merck Sharp & Dohme LLC (29) · Novartis Pharmaceuticals (27) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (18)

What is being tested here

Drugs under test in Hypercholesterolemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Inclisiran61323
Lerodalcibep479
Ezetimibe34794
Atorvastatin12972
Alirocumab12042
Evolocumab12436
Bempedoic acid1721
Enlicitide1610
MK-0616158
Phytosterols107

Drug classes tested here PCSK9 inhibitors 6 open · Statins 4 open · Angiotensin receptor blockers (ARBs) 1 open · Calcium channel blockers 5

Coming up

18phase 3 studies under way
39studies finish main data collection within a year5 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 55 Hypercholesterolemia studies recruiting now, 23 (42%) set no upper age limit and 20 (36%) stop at 75 or younger. 9 (16%) take children under 18. 1 (2%) are for women only and 1 (2%) for men only; 11 (20%) take healthy volunteers.

Recruiting studies that take each age, of 55
AgeWomenMen
109 (16%)8 (15%)
1844 (80%)44 (80%)
3047 (85%)47 (85%)
4050 (91%)50 (91%)
5050 (91%)50 (91%)
6549 (89%)49 (89%)
7539 (71%)39 (71%)
8530 (55%)30 (55%)

Across all 1,175 studies, recruiting or not: 42% stop at 75 or younger and 20% at 65; 9% take children; 2% are for women only and 3% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Hypercholesterolemia studies take

Of 125 phase 3 interventional studies under Hypercholesterolemia, half reached primary completion within 18 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 17 mo2–10 · 46 studies7 mo2–11 · 41 studies—
Phase 210 mo7–18 · 48 studies9 mo7–14 · 41 studies—
Phase 318 mo10–27 · 125 studies18 mo10–26 · 122 studies—
Phase 419 mo14–26 · 40 studies——
Interventional, no phase15 mo6–35 · 151 studies—16 mo6–36 · 133 studies
Observational34 mo22–61 · 51 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Started recruiting2

Results posted1

Newly registered3

Studies

Recruiting first, then most recently updated. Showing 50 of 1,175. Browse all 1,175 → or search them.