Methotrexate: all 649 studies that test it

Page 1 of 7. Open to participants first (88), then studies with results posted, then the rest; newest registration first within each.

• BRIDGE-NK: Immunotherapy Versus Chemotherapy Induction Followed by Autologous HSCT in Advanced NKTCLRecruitingNCT07678229Phase 3
• Immuno-Targeted Therapy Plus Low-Dose Chemotherapy for Newly Diagnosed Adult Ph-Negative B-ALL: A Prospective Umbrella TrialNot yet recruitingNCT07643103Phase 2
• Letrozole Versus Methotrexate for Management of Undisturbed Ectopic PregnancyNot yet recruitingNCT07624903Phase 2
• Comparison of Methotrexate and Tofacitinib in Chronic Plaque PsoriasisNot yet recruitingNCT07581418Not applicable
• The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed OsteosarcomaRecruitingNCT07560826Phase 2
• Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual TreatmentsRecruitingNCT07501507Phase 2/3
• Preventing Structural Damage in Early Psoriatic ArthritisRecruitingNCT07486843Phase 4
• Topical Methotrexate vs Minoxidil for Localized Alopecia AreataNot yet recruitingNCT07459933Phase 4
• A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered TogetherRecruitingNCT07446400Phase 1
• Methotrexate Versus Apremilast for Pruritus in PsoriasisNot yet recruitingNCT07432386Phase 4
• PD-1 Inhibitor Combined With Rituximab, Methotrexate, and Orelabrutinib (PD-1i+RMO) for Newly Diagnosed PCNSL and SCNSL.RecruitingNCT07410520Phase 2
• A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled GoutRecruitingNCT07388498Phase 3
• Cyclosporine Or Methotrexate for Pediatric Alopecia Areata: Routine Clinical Care Effectiveness StudyRecruitingNCT07381556Phase 4
• Methotrexate for Severe Vulvar Lichen SclerosusRecruitingNCT07352917Phase 2
• Utilization of a Microdevice for Psoriasis and Atopic DermatitisNot yet recruitingNCT07352566Phase 4
• A Multicenter, Prospective Clinical Trial With a Concurrent Control Evaluating Methotrexate Combined With Rituximab,Sintilimab and Pirtobrutinib vs. Investigator-Selected Standard of Care in Treatment-Naive PCNSLRecruitingNCT07350850Phase 2
• To Check Comparison of Apremilast and Methotrexate Efficacy in Patients With Moderate to Severe Plaque Psoriasis Presented to Tertiary Care HospitalRecruitingNCT07337434Early Phase 1
• A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)RecruitingNCT07280156Phase 2
• Comparison Between Oral Methotrexate and Tofacitinib in Chronic Plaque PsoriasisRecruitingNCT07261306Early Phase 1
• A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）RecruitingNCT07191431Not applicable
• Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OARecruitingNCT07161336Phase 2
• Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder ArthroplastyRecruitingNCT07138898Phase 2
• Genetic Variation in TRAF3IP2 (rs13190932)RecruitingNCT07086924Not applicable
• Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States PopulationRecruitingNCT06997068Phase 2
• ZR-MTX for PIOL Phase II TrialRecruitingNCT06973811Phase 2
• Comparing Effectiveness of Steroids and Methotrexate in Treatment of Chronic Inflammatory Breast DiseaseNot yet recruitingNCT06943482Phase 4
• Pragmatic, Open-Label Study to Pilot Evaluation for Clinical Trials in Relapsing PolychondritisRecruitingNCT06941376Phase 2
• Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study)RecruitingNCT06913907Phase 4
• Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity SyndromeRecruitingNCT06895473Phase 2
• Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis PatientRecruitingNCT06870500Not applicable
• Systemic Treatment Options for Generalized Lichen PlanusNot yet recruitingNCT06739551Phase 2
• Zanubrutinib in Combination With Pola-R-CHP and High-dose Methotrexate in Patients With Secondary CNS LymphomaRecruitingNCT06730542Phase 1
• Optimizing Treatment for Patients With Juvenile Idiopathic Arthritis in Sustained Remission: The MOVE-JIA TrialRecruitingNCT06653634Phase 4
• MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients With Active Rheumatoid ArthritisRecruitingNCT06649136Phase 4
• High-dose Methotrexate Combined with Thiotepa and Zanubrutinib in the Treatment of Newly Diagnosed PCNSL (MTZ)Not yet recruitingNCT06646211Phase 2
• A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)RecruitingNCT06615050Phase 3
• Molecular Subtype-Guided R-CHOP-MTX±Zanubrutinib Treatment in Newly Diagnosed DLBCL Patients with Central Nervous System InvolvementNot yet recruitingNCT06594432Phase 2
• Natrunix in Combination With Methotrexate for Rheumatoid Arthritis TreatmentNot yet recruitingNCT06590090Phase 2
• Effect of MTX Discontinuation on Shingrix Response in RARecruitingNCT06574594Not applicable
• A Study of Pomadomide in Combination With Rituximab and Methotrexate for Newly-diagnosed Primary Central Nervous System LymphomaRecruitingNCT06554561Phase 1/2
• Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) TrialRecruitingNCT06541574Phase 2
• MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) TrialRecruitingNCT06541249Phase 2
• Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and LymphomaRecruitingNCT06533748Phase 2
• Thalidomide for the Symptomatic Large Granular Lymphocytic LeukemiaRecruitingNCT06530576Phase 2
• A Phase Ib Clinical Trial of Peguricase for Injection With Methotrexate in Patients With Uncontrolled Gout.RecruitingNCT06298071Phase 1
• Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/LymphomaRecruitingNCT06289673Phase 4
• "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"RecruitingNCT06289205Phase 1/2
• Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.RecruitingNCT06239311Phase 3
• Drug Screening Using IMD in Bladder CancerEnrolling by invitationNCT06204614Early Phase 1
• Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic SyndromeRecruitingNCT06128070Phase 2
• A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Methotrexate in Elderly SubjectsEnrolling by invitationNCT06108453Phase 1
• Treatment of Newly Diagnosed Standard Risk Acute Lymphoblastic Leukemia in ChildrenRecruitingNCT06099366Phase 2
• BRE-08 Phase II Study of CMC Regimen for Early Stage Breast CancerRecruitingNCT06085742Phase 2
• Mini-dose MTX Plus Standard-dose Steroid for the Initial Treatment of Acute GVHDRecruitingNCT05921305Phase 3
• Effect of Adalimumab Therapy on Psoriasis PatientNot yet recruitingNCT05889338Not applicable
• TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia IIRecruitingNCT05848687Phase 1/2
• Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal CancerRecruitingNCT05725200Phase 2
• Selinexor in Combination With MTX+Ritu to Treat R/R CNSLRecruitingNCT05698147Phase 1/2
• Capizzi Escalating Methotrexate Versus High Dose Methotrexate in Children With Newly Diagnosed T-cell Lymphoblastic Lymphoma (T-LBL)RecruitingNCT05681260Phase 3
• The Clinical Efficacy of Immunomodulators in RA PatientsRecruitingNCT05626348Phase 4
• Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System LymphomaRecruitingNCT05600660Phase 2
• Methotrexate, Tafasitamab, Lenalidomide and Rituximab in Patients With PCNSLRecruitingNCT05583071Phase 2
• Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed MedulloblastomaRecruitingNCT05535166Phase 2
• B-cell Mature Non-Hodgkin's Lymphoma Treatment Protocol in Children and Adolescents 2021RecruitingNCT05518383Phase 4
• Immunoclassification of Psoriasis: a Strategy for Precision MedicineRecruitingNCT05503875Not applicable
• Allogeneic Hematopoietic Stem Cell Transplantation for 4/M NeuroblastomaNot yet recruitingNCT05303727Phase 2
• R-CDOP Combined With Intrathecal Methotrexate for DLBCL Patients With High-risk of CNS RelapseRecruitingNCT05257018Phase 2
• Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System LymphomaRecruitingNCT05135858Phase 1
• Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone TumorsRecruitingNCT05057130Phase 2/3
• Intermediate Dose of IV MTX as CNS Prophylaxis for High Risk DLBCLRecruitingNCT05054426Phase 3
• Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled TrialRecruitingNCT05040464Phase 3
• Efficacy, Safety and Costs of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior UveitisRecruitingNCT04798755Phase 3
• Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System LymphomaRecruitingNCT04737889Phase 2
• Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract CancerRecruitingNCT04628767Phase 2/3
• GVHD Prophylaxis With Methotrexate in Haploidentical HCT Using Posttransplant CyclophosphamideRecruitingNCT04622956Phase 1/2
• Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic ArthritisRecruitingNCT04610476Phase 3
• TPM Regimen (Thalidomide, Prednisone and Methotrexate) in LGLLRecruitingNCT04453345Phase 2/3
• Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous LineageRecruitingNCT04440267Phase 2
• Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)RecruitingNCT03970096Phase 2
• Intravitreal Methotrexate and R2(Rituximab & Lenalidomide) Regimen in Newly-diagnosed Primary Vitreoretinal LymphomaRecruitingNCT03746223Phase 2
• STep-up and Step-down Therapeutic Strategies in Childhood ARthritiSRecruitingNCT03728478Phase 3
• Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/LymphomaRecruitingNCT03719105Early Phase 1
• Cardiac Sarcoidosis Randomized TrialRecruitingNCT03593759Phase 3
• [CREMA]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS LymphomaRecruitingNCT03569995Phase 2
• Treatment of Rheumatoid Arthritis With DMARDs: Predictors of ResponseRecruitingNCT03414502Phase 3
• Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic LeukemiaRecruitingNCT03263572Phase 2
• A Randomized Trial of Chemotherapy in Surgical Patients With Infiltrating Ductal Carcinoma of BreastRecruitingNCT02897700Phase 1
• Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal MetastasisRecruitingNCT02422641Phase 2
• Comparison of Efficacy of Methotrexate and Azathioprine in Patients With Chronic Actinic Dermatitis: A Randomized Controlled TrialCompletedNCT06476366Early Phase 1Results posted
• A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory GoutCompletedNCT06229145Phase 4Results posted
• Premedication to Reduce Amivantamab Associated Infusion Related ReactionsActive, not recruitingNCT05663866Phase 2Results posted
• Pediatric Study of GVHD Ppx w/o Calcineurin Inhibitors After Day60 Post First Allo HSCT for Hematological Malignancies.TerminatedNCT05579769Phase 2Results posted
• A Study in Subjects With Retinitis PigmentosaCompletedNCT05392179Phase 2Results posted
• COVID-19 Booster Vaccine in Autoimmune Disease Non-RespondersTerminatedNCT05000216Phase 2Results posted
• Pegloticase and Methotrexate Co-administered in Participants With Uncontrolled Gout Who Previously Failed Pegloticase MonotherapyCompletedNCT04772313Phase 4Results posted
• A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout (FORWARD OL)CompletedNCT04762498Phase 4Results posted
• Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving MethotrexateCompletedNCT04511702Phase 4Results posted
• The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative VitreoretinopathyCompletedNCT04136366Phase 3Results posted
• Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled GoutCompletedNCT03994731Phase 4Results posted
• Etanercept Plus Methotrexate Versus Methotrexate Alone in Children With Polyarticular Course Juvenile Rheumatoid ArthritisTerminatedNCT03781375Phase 3Results posted

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