Drug
Mercaptopurine clinical trials
Also written Purinethol, Bw 57-323H, WR-2785 and Mercaptopurinum.
- studies test it
- 73
- open now
- 11
- in phase 3
- 22
- first study started
- 1993
Keep track of what changes. Save the Mercaptopurine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Other names
Combined with it in one product
Studies by the year they started
73 studies that test it; most in 2002 (6)
| Year | Studies |
|---|---|
| 1993 | 1 |
| 1996 | 5 |
| 1997 | 1 |
| 1998 | 2 |
| 1999 | 3 |
| 2000 | 2 |
| 2002 | 6 |
| 2003 | 4 |
| 2004 | 3 |
| 2005 | 2 |
| 2006 | 1 |
| 2007 | 5 |
| 2008 | 4 |
| 2009 | 1 |
| 2010 | 2 |
| 2011 | 1 |
| 2012 | 2 |
| 2013 | 3 |
| 2014 | 1 |
| 2015 | 4 |
| 2016 | 5 |
| 2017 | 2 |
| 2018 | 1 |
| 2020 | 1 |
| 2021 | 1 |
| 2022 | 2 |
| 2023 | 2 |
| 2024 | 3 |
| 2025 | 1 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 8
- Phase 2
- 35
- Phase 3
- 22
- Phase 4
- 9
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 70
St. Jude Children's Research Hospital (12) · Children's Oncology Group (9) · National Cancer Institute (NCI) (5) · Children's Cancer Group, China (2) · Goethe University (2) · SWOG Cancer Research Network (2) · Institute of Hematology & Blood Diseases Hospital, China (2) · Sun Yat-sen University (2)
Often tested with
Tested in the same studies.
Methotrexate (50) · Vincristine (44) · Cytarabine (41) · Cyclophosphamide (37) · Dexamethasone (36) · Daunorubicin (31) · Etoposide (25) · Prednisone (25)
Studies
Open first, then newest update. How each study uses Mercaptopurine is read from its arms, and is right about nine times in ten.
Testing it · 73
- Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney CancerNot yet recruitingPhase 1Jonsson Comprehensive Cancer CenterNCT07716735Written as Mercaptopurine
- Treatment of Newly Diagnosed Standard Risk Acute Lymphoblastic Leukemia in ChildrenRecruitingPhase 2Hee Young JuNCT06099366Written as Delayed Intesification(DI): Vincristine, Mercaptopurine, L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Dexamethasone, Intrathecal Methotrexate
- Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and LymphomaRecruitingPhase 2St. Jude Children's Research HospitalNCT06533748Written as 6-Mercaptopurine
- Immuno-Targeted Therapy Plus Low-Dose Chemotherapy for Newly Diagnosed Adult Ph-Negative B-ALL: A Prospective Umbrella TrialNot yet recruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT07643103Written as Mercaptopurine 50 mg
- Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)RecruitingPhase 2University of ChicagoNCT04747912Written as Purinethol (6-Mercaptopurine)
- TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia IIRecruitingPhase 1/2Tanja Andrea GruberNCT05848687Written as Mercaptopurine
- Capizzi Escalating Methotrexate Versus High Dose Methotrexate in Children With Newly Diagnosed T-cell Lymphoblastic Lymphoma (T-LBL)RecruitingPhase 3Children's Cancer Group, ChinaNCT05681260Written as Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin
- Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous LineageRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT04440267Written as mercaptopurine
- A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS PatientsRecruitingPhase 1/2Haukeland University HospitalNCT06199557Written as 6-Mercaptopurine (6-MP)
- Efficacy and Safety of TMZ Plus 6-MP in the Patients With Recurrent GlioblastomaRecruitingPhase 1/2The First Affiliated Hospital with Nanjing Medical UniversityNCT06279767Written as 6-mercaptopurine
- A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained ProtocolRecruitingPhase 3Shanghai Children's Medical CenterNCT04773366Written as Prednisone+Cytarabine+vincristine+Mercaptopurine
- Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic LeukemiaActive, not recruitingPhase 3National Cancer Institute (NCI)NCT02101853Written as Mercaptopurine
- A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at HomeSuspendedNot applicableChildren's Oncology GroupNCT06639958Written as Mercaptopurine
- A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic LeukemiaActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT01920737Written as 6-MP (6-Mercaptopurine)
- Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic LeukemiaActive, not recruitingPhase 2National Cancer Institute (NCI)NCT02143414Written as Mercaptopurine
- Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) IActive, not recruitingPhase 1/2St. Jude Children's Research HospitalNCT02553460Written as Mercaptopurine
- Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and LymphomaActive, not recruitingPhase 2/3St. Jude Children's Research HospitalNCT03117751Written as Mercaptopurine
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedPhase 2Alliance for Clinical Trials in OncologyNCT00558519Written as mercaptopurine
- LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell HistiocytosisActive, not recruitingPhase 2/3North American Consortium for HistiocytosisNCT02205762Written as mercaptopurine
- LBL-2016 for Children or Adolescents in ChinaActive, not recruitingPhase 3Children's Cancer Group, ChinaNCT02845882Written as Prednisone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine
See all 73 studies that test Mercaptopurine →
Given in every arm · 86 — Mercaptopurine is usual care beside what is tested
- A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingPhase 2National Cancer Institute (NCI)NCT06124157Written as Mercaptopurine
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged LeukemiaRecruitingPhase 2National Cancer Institute (NCI)NCT06317662Written as Mercaptopurine
- Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic LeukemiaRecruitingPhase 3Alliance for Clinical Trials in OncologyNCT03150693Written as Mercaptopurine
- Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More TreatmentNot yet recruitingPhase 2SWOG Cancer Research NetworkNCT07636564Written as Mercaptopurine
- Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaRecruitingPhase 2City of Hope Medical CenterNCT06918431Written as Mercaptopurine
- Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaRecruitingPhase 2M.D. Anderson Cancer CenterNCT00501826Written as Mercaptopurine
- Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic LeukemiaRecruitingPhase 2M.D. Anderson Cancer CenterNCT05645718Written as Mercaptopurine
- Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell NeoplasmRecruitingPhase 2M.D. Anderson Cancer CenterNCT04216524Written as Mercaptopurine
- A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingPhase 2National Cancer Institute (NCI)NCT04546399Written as Mercaptopurine
- Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLyRecruitingPhase 3Children's Oncology GroupNCT03959085Written as Mercaptopurine
- ALL Backbone in AYAsRecruitingPhase 2Dana-Farber Cancer InstituteNCT07227584Written as Mercaptopurine
- Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)RecruitingPhase 2St. Jude Children's Research HospitalNCT06390319Written as Mercaptopurine
- Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic LeukemiaRecruitingPhase 1/2M.D. Anderson Cancer CenterNCT01371630Written as Mercaptopurine
- Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic LeukemiaRecruitingPhase 1University of ChicagoNCT03571321Written as Mercaptopurine
- Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic LeukemiaRecruitingPhase 2M.D. Anderson Cancer CenterNCT02877303Written as Mercaptopurine
- International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic LymphomaRecruitingPhase 3University Hospital MuensterNCT04043494Written as 6-Mercaptopurine
- Modified LCH-III Regimen With or Without Luvometinib for Multisystem Pediatric Langerhans Cell HistiocytosisRecruitingNot applicableWest China Second University HospitalNCT07431060Written as Mercaptopurine
- Efficacy and Safety of Low-dose Chemotherapy Plus Immuno-targeted Drugs in Newly Diagnosed Adult Ph- B-ALLRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT06387121Written as 6-mercaptopurine
- Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic LeukemiaRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT05660473Written as 6-mercaptopurine
- Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017RecruitingPhase 3Martin SchrappeNCT03643276Written as 6-Mercaptopurine
Showing 20 of 86.
As the comparator · 10 — what is tested is compared with Mercaptopurine
- Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and AdolescentsActive, not recruitingPhase 3Dana-Farber Cancer InstituteNCT03020030Written as MERCAPTOPURINE
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic LymphomaCompletedPhase 3National Cancer Institute (NCI)NCT00408005Written as Mercaptopurine
- Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic LeukemiaCompletedPhase 3Technische Universität DresdenNCT02688140Written as Mercaptopurine
- Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified TreatmentCompletedPhase 3Goethe UniversityNCT02881086Written as Mercaptopurine
- Phase III Trial in Acute Promyelocytic Leukemia PatientsCompletedPhase 3Gruppo Italiano Malattie EMatologiche dell'AdultoNCT00482833Written as mercaptopurine
- Cost-effectiveness of TPMT PharmacogeneticsCompletedNot applicableZonMw: The Netherlands Organisation for Health Research and DevelopmentNCT00521950Written as azathioprine (AZA) or 6-mercaptopurine (6-MP)
- Multicenter Clinical Efficacy and Safety Study of Delayed Release 6MP in Crohn's DiseaseTerminatedPhase 1/2Teva GTCNCT01094613Written as 6 Mercaptopurine
- Adalimumab for the Management of Post-operative Crohn's Disease (CD)Status unknownPhase 3Tel-Aviv Sourasky Medical CenterNCT01629628Written as 6 Mercaptopurine
- Comparison of Two Treatments in Intermediate and High-risk Acute Promyelocytic Leukemia (APL) Patients to Assess Efficacy in 1st Hematological Complete Remission and Molecular RemissionCompletedPhase 3Wyeth is now a wholly owned subsidiary of PfizerNCT00962767Written as ATRA plus 6-MP and MTX
- Pilot Comparative Bioavailability Study of 6Mercaptopurine (Delayed Release vs. Purinethol) in Crohns Disease PatientsCompletedPhase 1Teva GTCNCT00774982Written as 6 Mercaptopurine
Codes
What other systems call Mercaptopurine · ClinicalTrials.gg INT008442
- MeSH (NLM) D015122MercaptopurineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) E7WED276I5MERCAPTOPURINEConfirmed FDA, NLM, Wikidata
- RxNorm 103Confirmed FDA, Wikidata
- Wikidata Q27114691mercaptopurine hydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C195MercaptopurineConfirmed FDA, Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D015122 | Mercaptopurine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | E7WED276I5 | MERCAPTOPURINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 103 | — | Confirmed FDA, Wikidata |
| Wikidata | Q27114691 | mercaptopurine hydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C195 | Mercaptopurine | Confirmed FDA, Wikidata |
Also registered as mercaptopurine anhydrous (UNII PKK6MUZ20G · RxNorm 1546028).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.