Levomefolic acid clinical trials
Also written L-methylfolate.
How each study uses levomefolic acid is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the levomefolic acid studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
24 studies that test it; most in 2025 (3)
| Year | Studies |
|---|---|
| 1998 | 1 |
| 2004 | 1 |
| 2006 | 2 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 2 |
| 2014 | 1 |
| 2017 | 1 |
| 2019 | 2 |
| 2020 | 1 |
| 2022 | 1 |
| 2023 | 2 |
| 2024 | 2 |
| 2025 | 3 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 4 · Other 20
University of British Columbia (4) · Bayer (3) · University of Ulster (1) · Oklahoma State University Center for Health Sciences (1) · Dr. Soetomo General Hospital (1) · Alexandria University (1) · Riphah International University (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1)
Often tested with
Tested in the same studies.
Vitamin B 12 (3) · Riboflavin (2) · Mecobalamin (2) · Magnesium (2) · EE20 (2) · Folic Acid (2) · Omega-3 fatty acid (1) · Niacinamide (1)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 3, 1 in phase 3
Studies that test levomefolic acid, phase 3 first.
- Sep 2027Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian SyndromePhase 3 · University Hospital, Lille
- Dec 2026Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA FormationNot applicable · University of British Columbia
- Aug 2027The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver DiseaseNot applicable · Tabriz University of Medical Sciences
Studies
Open first, then newest update. How each study uses levomefolic acid is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 24
- The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver DiseaseNot yet recruitingNot applicableTabriz University of Medical SciencesNCT07740109Written as 5-methyltetrahydrofolate (5-MTHF)
- Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian SyndromeRecruitingPhase 3University Hospital, LilleNCT03059173Written as Myo-Inositol + Levomefolic acid
- Pharmacokinetic Study of Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) After Administration of CreNeuroS® CNS Fish Oil Plus Softgels in Healthy Subjects Under Fasting ConditionsNot yet recruitingNot applicableSichuan Credit Pharmaceutical Co., Ltd.NCT07461649Written as Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF)
- Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot StudyRecruitingPhase 4Queen's UniversityNCT06218030Written as L-methylfolate
- 5-MTHF Supplementation for Treatment of Type 1 Diabetes PatientsNot yet recruitingNot applicableShanghai Changzheng HospitalNCT06930144Written as active folate
- PREconception Folic Acid Clinical Efficacy (PREFACE) TrialNot yet recruitingNot applicableUniversity of British ColumbiaNCT06641245Written as 5-MTHF (5-methyltetrahydrofolate)
- Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA FormationNot yet recruitingNot applicableUniversity of British ColumbiaNCT01687127Written as 5-methyltetrahydrofolate, calcium salt
- Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant WomenCompletedNot applicableDr. Soetomo General HospitalNCT06935630Written as 5-MTHF (5-methyltetrahydrofolate)
- Optimal Nutrition for Prevention of Hypertension in PregnancyActive, not recruitingNot applicableUniversity of UlsterNCT04723836Written as 5-methyltetrahydrofolate (400µg)
- Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated with Elevated Serum Homocysteine in Hemodialysis Patients.CompletedPhase 4Alexandria UniversityNCT05807711Written as L-Methyl Folate and methylcobalamine
- Combination Therapy of Different Antidepressants With Dietary SupplementsCompletedNot applicableRiphah International UniversityNCT05931965Written as L-methylfolate
- Food and Alcohol Behavior Study: Meaningful EnhancementActive, not recruitingNot applicableOklahoma State University Center for Health SciencesNCT04095052Written as Methyl Folate
- Natural Folate vs. Synthetic Folic Acid in PregnancyCompletedNot applicableUniversity of British ColumbiaNCT04022135Written as (6S)-5-methyltetrahydrofolic acid
- Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of AgeStatus unknownPhase 4King Edward Medical UniversityNCT04782037Written as L-Methylfolate Calcium
- 5-methyltetrahydrofolate Survival and Inflammation in ESRD PatientsCompletedNot applicableIRCCS Azienda Ospedaliero-Universitaria di BolognaNCT00626223Written as 5-MTHF (5-methyltetrahydrofolate)
- Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)CompletedPhase 1University of IowaNCT01381354Written as methyl folate
- L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD AdultsCompletedPhase 2/3Massachusetts General HospitalNCT01853280Written as L-methylfolate
- Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking ContraceptionCompletedPhase 3BayerNCT01902264Written as EE20/DRSP/L-5-MTHF (Beyaz, BAY98-7071)
- Folic Acid vs 5-methyltetrahydrofolate (5MTHF) in Recurrent AbortionCompletedPhase 2/3National Nutrition and Food Technology InstituteNCT01976676Written as 5-methyltetrahydrofolate
- An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's DiseaseTerminatedNot applicableNorthwell HealthNCT00853879Written as B6, B12, L-methylfolate
See all 24 studies that test levomefolic acid →
Given beside what is tested · 2 — levomefolic acid is usual care or a partner of the new treatment
- China Stroke Primary Prevention Trial 2 for Participants with Hypertension and MTHFR 677 TT GenotypeRecruitingPhase 4Shenzhen Ausa Pharmed Co.,LtdNCT04974151Written as 5-methyltetrahydrofolate (5-MTHF)
- Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.WithdrawnNot applicableJohn D. Dingell VA Medical CenterNCT02223299Written as deplin
Codes
What other systems call levomefolic acid · ClinicalTrials.gg INT002357
- UNII (FDA) 8S95DH25XCLEVOMEFOLIC ACIDConfirmed FDA, NLM, Wikidata
- RxNorm 1025342Confirmed FDA, Wikidata
- Wikidata Q192553levomefolic acidConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C81119Levomefolic AcidConfirmed FDA, Wikidata
- DrugBank DB11256One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | 8S95DH25XC | LEVOMEFOLIC ACID | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1025342 | — | Confirmed FDA, Wikidata |
| Wikidata | Q192553 | levomefolic acid | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C81119 | Levomefolic Acid | Confirmed FDA, Wikidata |
| DrugBank | DB11256 | — | One source Wikidata |
Also registered as 5-methyltetrahydrofolic acid (UNII TYK22LML8F · RxNorm 1313966).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.