Generalized Anxiety Disorder clinical trials
The registry lists 518 studies for Generalized Anxiety Disorder across more than 10 countries. 125 are recruiting or about to start. 315 of them are mainly about Generalized Anxiety Disorder (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 753 studies for Generalized Anxiety Disorder. How that becomes 517 here
This page counts the studies the registry files under Generalized Anxiety Disorder, and those it files under no condition that list Generalized Anxiety Disorderthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 753Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1List Generalized Anxiety Disorder as a condition, but the registry did not file them under itMost often written as “Analogue Generalized Anxiety Disorder” (1). The registry filed them under other conditions only, most often Anxiety Disorders (1).
- −235Match it another way42 name it in the title, 7 in a keyword, and 186 by a synonym or other text the search reads.
- 517The count on this page2 of them list Generalized Anxiety Disorder in their own words; the registry filed them under no condition.
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Status
Who runs them
Pfizer (13) · Baylor College of Medicine (11) · Massachusetts General Hospital (11) · Karolinska Institutet (11) · University of South Florida (9) · AstraZeneca (9) · University of Pennsylvania (7) · University of California, Los Angeles (6)
What is being tested here
Drugs under test in Generalized Anxiety Disorder studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Deulumateperone | 4 | 2 | 4 |
| SEP-363856 | 3 | 4 | 4 |
| ABBV-932 | 1 | 0 | 3 |
| Cannabidiol | 1 | 2 | 2 |
| Luvesilocin | 1 | 0 | 1 |
| Psilocybin | 1 | 0 | 1 |
| Crisugabalin | 1 | 0 | 1 |
| Levomefolic acid | 1 | 0 | 1 |
| Quetiapine | 0 | 7 | 14 |
| Imagabalin | 0 | 6 | 10 |
Drug classes tested here Serotonin receptor agonists 2 open · Psychedelics 1 open · Antipsychotics 20 · SSRIs 18 · SNRIs 8
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027Clinical Trial to Evaluate the Efficacy and Safety of the Aurora® Digital Medical Device in Adult Patients With Moderate to Severe Generalized Anxiety Disorder · Phase 3 · Psicofarma, S.A. De C.V.
- Aug 2027Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder · Phase 3 · Wayne State University
- Nov 2026Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders · Amsterdam UMC, location VUmc
- Nov 2026Testing a Precision Psychotherapy System for Low-income Patients · National Council of Scientific and Technical Research, Argentina
- Nov 2026Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder · AbbVie
- Dec 2026Metacognitive Therapy Compared to Cognitive-behavioral Therapy · Karolinska Institutet
- Dec 2026Oral Surgery Virtual Reality Glasses Study · Boston University
- Dec 2026Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD) · University of California, Los Angeles
- Dec 2026CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy · Jasper A. Smits
- Dec 2026Effectiveness of Solution-Focused Therapy for Generalized Anxiety Disorder in Emerging Adults · International Islamic University, Islamabad
Who these studies take
Of the 86 Generalized Anxiety Disorder studies recruiting now, 32 (37%) set no upper age limit and 52 (60%) stop at 75 or younger. 15 (17%) take children under 18. 2 (2%) are for women only and 0 (0%) for men only; 16 (19%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (9%) | 8 (9%) |
| 18 | 78 (91%) | 76 (88%) |
| 30 | 74 (86%) | 72 (84%) |
| 40 | 71 (83%) | 69 (80%) |
| 50 | 69 (80%) | 67 (78%) |
| 65 | 63 (73%) | 61 (71%) |
| 75 | 35 (41%) | 34 (40%) |
| 85 | 32 (37%) | 31 (36%) |
Across all 518 studies, recruiting or not: 63% stop at 75 or younger and 56% at 65; 17% take children; 3% are for women only and <1% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Generalized Anxiety Disorder studies take
Of 183 interventional studies with no phase under Generalized Anxiety Disorder, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo15–53 · 183 studies | — | 29 mo16–55 · 174 studies |
| Observational | 17 mo9–56 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting5
- LIFU for Chronic Pain and Generalized Anxiety DisorderNov 9, 2026NCT07686354
- Student Precarity and PsychiatryNov 6, 2026NCT07618208
- A Study of JNJ-99245354 (ITI-1284) as an Adjunctive Treatment in Participants With Generalized Anxiety Disorder (GAD) Who Have an Inadequate Response to GAD TreatmentNov 3, 2026NCT07856420
- Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging MechanismsOct 21, 2026NCT07392645
- A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety DisorderOct 20, 2026NCT07786454
Newly registered9
- Auricular Vagus Nerve Stimulation for Anxiety and Sleep Quality in Patients With Generalized Anxiety DisorderNov 12, 2026NCT07930871
- Inspiratory Muscle Training and Diaphragmatic Breathing in GADNov 3, 2026NCT07913503
- Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled TrialNov 2, 2026NCT07908628
- Temporal Interference Transcranial Alternating Current Stimulation Targeting the BNST or Amygdala for Generalized Anxiety DisorderNov 2, 2026NCT07909200
- Microbiota Modulation for Psychiatry PatientsOct 27, 2026NCT07899424
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- Neural Mechanisms of Real-world Emotions and InternalizingOct 23, 2026NCT07891624
- Effectiveness of Single-Session Acceptance and Commitment Therapy for Generalized Anxiety Symptoms.Oct 23, 2026NCT07892768
- Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and AnxietyOct 15, 2026NCT07876453
- Digital Single-Session Cognitive Behavioural Therapy in Healthy AdultsOct 14, 2026NCT07873905
Studies
Recruiting first, then most recently updated. Showing 50 of 518. Browse all 518 → or search them.
- A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety DisorderRecruitingNCT07767903Phase 31 country
- Auricular Vagus Nerve Stimulation for Anxiety and Sleep Quality in Patients With Generalized Anxiety DisorderNot yet recruitingNCT07930871Not applicable
- A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety DisorderRecruitingNCT07786454Phase 31 country
- Multimodal Cohort Study of Generalized Anxiety DisorderNot yet recruitingNCT077642111 country
- LIFU for Chronic Pain and Generalized Anxiety DisorderRecruitingNCT07686354Not applicable1 country
- Student Precarity and PsychiatryRecruitingNCT076182081 country
- A Study of JNJ-99245354 (ITI-1284) as an Adjunctive Treatment in Participants With Generalized Anxiety Disorder (GAD) Who Have an Inadequate Response to GAD TreatmentRecruitingNCT07856420Phase 31 country
- Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety DisorderRecruitingNCT06480383Phase 26 countries
- Inspiratory Muscle Training and Diaphragmatic Breathing in GADRecruitingNCT07913503Not applicable1 country
- Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety DisorderRecruitingNCT06701903Phase 25 countries
- A Study to Asses Safety and Tolerability of ITI-1284 Given Alone or as an Additional Treatment in Participants With Generalized Anxiety Disorder (GAD)RecruitingNCT07807865Phase 31 country
- Temporal Interference Transcranial Alternating Current Stimulation Targeting the BNST or Amygdala for Generalized Anxiety DisorderNot yet recruitingNCT07909200Not applicable1 country
- Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled TrialNot yet recruitingNCT07908628Not applicable1 country
- CannaRiver CBD Calm for Anxiety, Sleep, and Well-Being in Adults With Generalized Anxiety DisorderNot yet recruitingNCT07821840Not applicable
- Microbiota Modulation for Psychiatry PatientsNot yet recruitingNCT07899424Phase 1
- Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging MechanismsRecruitingNCT07392645Not applicable1 country
- A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety DisorderRecruitingNCT07759128Phase 31 country
- Miles for Mental HealthNot yet recruitingNCT07541443Not applicable
- Neural Mechanisms of Real-world Emotions and InternalizingRecruitingNCT07891624Not applicable1 country
- Cannabidiol-Assisted Learning for Managing Generalized Anxiety DisorderRecruitingNCT07123467Phase 31 country
- Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied RelaxationNot yet recruitingNCT07866794Not applicable1 country
- Ultra-brief Psychological Treatments for Emotional Symptoms and DisordersRecruitingNCT06909669Not applicable1 country
- RE104 Safety and Efficacy Study in Generalized Anxiety DisorderRecruitingNCT07489651Phase 21 country
- Device for Treating Generalized AnxietyRecruitingNCT07819773Not applicable1 country
- Continuous Theta Burst Stimulation for Generalized Anxiety DisorderRecruitingNCT07770919Not applicable1 country
- Acupuncture for Generalized Anxiety DisorderNot yet recruitingNCT07798986Not applicable1 country
- Effectiveness of Solution-Focused Therapy for Generalized Anxiety Disorder in Emerging AdultsRecruitingNCT07798063Not applicable1 country
- Anxiety Skills StudyRecruitingNCT07774481Not applicable1 country
- Metacognitive Therapy Compared to Cognitive-behavioral TherapyRecruitingNCT07382323Not applicable1 country
- Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderRecruitingNCT06969170Phase 21 country
- Efficacy of Expectancy Focused Exposure Therapy for Anxiety DisordersRecruitingNCT07753330Not applicable1 country
- Qualitative Study of Student Financial Insecurity and PsychiatryNot yet recruitingNCT077198161 country
- Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.RecruitingNCT071170581 country
- Testing Delivery Modalities of Team-Based CBT for Pediatric Anxiety in Community Health Settings.RecruitingNCT06934525Not applicable1 country
- Mindful Self-Compassion for Anxiety Disorders and DepressionRecruitingNCT05671419Not applicable1 country
- Oral Surgery Virtual Reality Glasses StudyRecruitingNCT06723158Not applicable1 country
- Mobile Intervention for Mental Health of Family Caregivers in ThailandRecruitingNCT06722287Not applicable1 country
- Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental IllnessRecruitingNCT06376734Phase 21 country
- Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot StudyRecruitingNCT07429578Not applicable1 country
- Non-Coding RNAs Gene Expression in Psychiatric DisordersNot yet recruitingNCT076499931 country
- A Phase 2a Efficacy, Safety, Tolerability, and PK Study of SYT-510 in Participants With Generalized Anxiety DisorderRecruitingNCT07478744Phase 21 country
- Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety DisorderRecruitingNCT06846320Phase 22 countries
- Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety DisorderNot yet recruitingNCT07648797Not applicable1 country
- MRI-Guided Accelerated cTBS for Generalized Anxiety DisorderNot yet recruitingNCT07640945Not applicable
- CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyRecruitingNCT05467683Not applicable1 country
- Serotonin Variants & Gut Microbiota in Mental HealthNot yet recruitingNCT07634458
- Personalized AI-Driven Models in Cognitive Behavioral Therapy for AnxietyRecruitingNCT07430800Not applicable1 country
- Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4RecruitingNCT06563310Not applicable1 country
- AI-Supported Therapy for Depression and Anxiety Compared With Standard CBTNot yet recruitingNCT07620340Not applicable
- Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental DisordersRecruitingNCT076047531 country