An interventional study of L-tyrosine and L-Tryptophan in Depression, sponsored by John D. Dingell VA Medical Center. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-02-21.
Sponsored by John D. Dingell VA Medical Center · Not applicable, Interventional, and Other
**This study never received IRB approval and no participants were ever enrolled** The purpose of this study is to determine if adding over the counter nutritional supplements will have a benefit to participants currently taking prescribed antidepressants who have not experienced complete remission of their depression symptoms.
Inclusion Criteria:
Detroit VA Patients with major depression, mild to moderate treated with an SSRI and not having complete remission of symptoms as defined by "feeling their normal selves"
Randomized into two groups:
Experimental: will receive month supply of deplin 15mg, L-tyrosine 6g/d into 2 divided doses, and L-tryptophan 2g/d into 2 divided doses.
Control: will receive month supply of deplin 15mg , and 2 placebo pills.
Beck Depression Scale (BDI-2) to be administered at baseline and every 2 weeks for 1 month.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
Browse Depression studies →John D. Dingell VA Medical Center is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
**This study never received IRB approval and no participants were enrolled**
Inclusion Criteria:
deplin 15mg plus L-Tyrosine 6g/d and L-Tryptophan 2g/d for 30 days
Dietary Supplement: L-tyrosine · Dietary Supplement: L-Tryptophan · Drug: deplin
deplin 15mg daily plus Placebo A and Placebo B for 30 days
Drug: deplin · Other: Placebo A · Other: Placebo B
6g/d daily for 30 days
2g/d daily for 30 days
15mg daily for 30 days
Also known as: L-methylfolate
a sugar-pill that looks like a real medication
a sugar-pill that looks like a real medication
Benefit of nutritional supplement
Through participant interviews and Beck Depression scale determine if adding nutritional supplements improve or resolve complete remission of depression symptoms.
Time frame: 30 days
Plan to share: No — This study never received IRB approval and never enrolled any participants. ClinicalTrials.gov entry should be removed.
No publications or documents are linked to this record.
This study is withdrawn, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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John D. Dingell VA Medical Center