Hyperhomocysteinemia clinical trials
The registry lists 34 studies for Hyperhomocysteinemia across more than 10 countries. 4 are recruiting or about to start. 12 of them are mainly about Hyperhomocysteinemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Homocystinuria too: 54 studies, 9 open.
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Who runs them
Shenzhen Ausa Pharmed Co.,Ltd (2) · S.LAB (SOLOWAYS) (2) · Huilian Zhu (1) · Asociación Científica Latina A.C. (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · I.M. Sechenov First Moscow State Medical University (1) · SingHealth Polyclinics (1) · Center for Health, Exercise and Sport Sciences, Serbia (1)
What is being tested here
Drugs under test in Hyperhomocysteinemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Folic Acid | 0 | 1 | 5 |
| Enalapril | 0 | 1 | 2 |
| Levomefolic acid | 0 | 0 | 1 |
| Vitamin B 12 | 0 | 0 | 1 |
| S-Adenosylmethionine | 0 | 0 | 1 |
| Vitamin Supplement | 0 | 1 | 1 |
| Mecobalamin | 0 | 0 | 1 |
Who these studies take
Of the 3 Hyperhomocysteinemia studies recruiting now, 1 (33%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (33%) | 1 (33%) |
| 18 | 3 (100%) | 3 (100%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 3 (100%) | 3 (100%) |
| 75 | 3 (100%) | 3 (100%) |
| 85 | 2 (67%) | 2 (67%) |
Across all 34 studies, recruiting or not: 44% stop at 75 or younger and 24% at 65; 21% take children; 3% are for women only and 6% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 34 of 34. search them.
- Oral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With HyperhomocysteinemiaNot yet recruitingNCT07928180Not applicable1 country
- Clinical and Laboratory Study of Methylmalonic AcidemiaRecruitingNCT000780781 country
- Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed HypertensionRecruitingNCT074802651 country
- Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.RecruitingNCT06264570Not applicable1 country
- Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.CompletedNCT06163443Not applicable1 country
- Metabolic Disorders and VertigoStatus unknownNCT049359701 country
- 5-methyltetrahydrofolate Survival and Inflammation in ESRD PatientsCompletedNCT00626223Not applicable1 country
- Methylenetetrahydrofolate Reductase Deficiency in Ischemic StrokeCompletedNCT04287881Not applicable1 country
- The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and TreatmentCompletedNCT02575092Phase 2/31 country
- Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults With HyperhomocysteinemiaStatus unknownNCT03720249Not applicable1 country
- Effectiveness of a Micronutrient Supplement to Lower Plasma Homocysteine MDEG2 Pilot Supplementation TrialCompletedNCT03431597Phase 21 country
- The Dual Impact of Homocysteine and Cholesterol on Cognitive FunctionsCompletedNCT036312381 country
- Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular EventsCompletedNCT00317005Phase 41 country
- Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic PatientsCompletedNCT02540642Not applicable1 country
- Effect of S-adenosylmethionine (SAMe) on Blood Levels of HomocysteineCompletedNCT00473200Phase 11 country
- Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly DiabeticsCompletedNCT033764901 country
- Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian IndividualsCompletedNCT02961972Not applicable1 country
- Feasibility Study of the Intensive Systolic Blood Pressure ControlStatus unknownNCT02817503Phase 41 country
- COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICECompletedNCT02860338
- Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial FunctionCompletedNCT02392767Not applicable1 country
- Homocysteine and Progression of AtherosclerosisCompletedNCT00005338
- Study of Chronic Degenerative DiseasesCompletedNCT024959611 country
- Homocyst(e)Ine, Vitamin Status, and CVD RiskCompletedNCT00005482
- CSPPT- Chronic Kidney Diseases StudyWithdrawnNCT01871740Phase 41 country
- Plasma Homocysteine Distribution in the United StatesCompletedNCT00005483
- Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese ChildrenCompletedNCT01766310Phase 41 country
- Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese ElderlyCompletedNCT00755664Phase 31 country
- Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving HemodialysisCompletedNCT00004495Not applicable1 country
- Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical TrialCompletedNCT01661309Not applicable1 country
- A Retrospective Analysis of Cerefolin NAC® in Cognitively Impaired PatientsStatus unknownNCT015945411 country
- Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma HomocysteineStatus unknownNCT01848873Phase 2/31 country
- The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy VolunteersCompletedNCT01371357Phase 31 country
- Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) PatientsCompletedNCT01391416
- The Effect of Folic Acid Administration in the Progression of MicroalbuminuriaCompletedNCT00737126Not applicable1 country