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Leucovorin clinical trials

Also written Folinic acid, Wellcovorin and NSC-3590.

studies test it
310
open now
51
in phase 3
64
first study started
1992

Counted the way a researcher would: Leucovorin with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.

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How each study uses Leucovorin is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

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Approvals

The first approval found in each region, with its record

United States
20 Jun 1952 · LEUCOVORIN CALCIUM · NDA 008107 (FDA, Drugs@FDA)
European Union
Not in EMA's list of EU-wide authorisations

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Leucovorin
118
leucovorin calcium
72
LV
22
CF
12
citrovorum factor
12

Brand

Wellcovorin
20
Lederfolin
1
Rescuvolin
1

Development codes

NSC-3590
2
NSC 03590
1

Other names

Folinic acid
81
Calcium Folinate
5

In one entry with another drug

Given together, or one or the other

POF
6
FLOT
3
Oxaliplatin + 5-Fluorouracil/Leucovorin
3
FLOT Chemotherapy
2
S-1, leucovorin, oxaliplatin
2
HR070803; Oxaliplatin; 5Fluorouracil; Calcium folinate
2
mFOLFIRINOX Treatment Regimen
2
Oxaliplatin, Leucovorin, fluorouracil
2

Studies by the year they started

307 studies that test it; most in 2011 (18)

Studies that test Leucovorin, by start year
YearStudies
19922
19932
19944
19952
19964
19974
19982
19995
20008
20014
20029
200312
200412
200510
200614
20077
20083
200913
201011
201118
201216
20139
201411
201513
20168
20177
201814
201914
202012
202112
20225
20239
202410
202510
202611

By phase

A phase 1/2 study counts in both.

Early Phase 1
1
Phase 1
56
Phase 2
205
Phase 3
64
Phase 4
4
No phase
8

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Colorectal Neoplasms
47
Stomach Neoplasms
31
Pancreatic Neoplasms
27
Rectal Neoplasms
17
Colonic Neoplasms
12
Biliary Tract Neoplasms
10
Precursor Cell Lymphoblastic Leukemia-Lymphoma
8
Carcinoma, Hepatocellular
7
Leukemia
6
Autism Spectrum Disorder
6
Neoplasms
6
Lymphoma
6

Who runs them

Industry 34 · Other 276

National Cancer Institute (NCI) (13) · M.D. Anderson Cancer Center (10) · National Health Research Institutes, Taiwan (10) · Children's Oncology Group (9) · University of Miami (7) · Fujian Cancer Hospital (7) · Memorial Sloan Kettering Cancer Center (6) · Alliance for Clinical Trials in Oncology (5)

Often tested with

Tested in the same studies.

Fluorouracil (223) · Oxaliplatin (148) · Irinotecan (85) · Docetaxel (34) · Cisplatin (30) · Capecitabine (27) · Methotrexate (26) · Paclitaxel (25)

Related medicines

As reviewed, each with the page that says it.

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Tested against it · 12 phase 3 studies under way

Leucovorin is the comparator. A study of two new drugs counts under both.

  • 1Ipilimumab · Bristol-Myers Squibb
  • 1Nivolumab · Bristol-Myers Squibb
  • 1Daraxonrasib · Revolution Medicines, Inc.
  • 1Pembrolizumab · Merck Sharp & Dohme LLC · next primary completion Sep 2028
  • 1Tambotatug pelitecan · MediLink Therapeutics (Suzhou) Co., Ltd. · next primary completion Jan 2029
  • 1Alveltamig · Suzhou Zelgen Biopharmaceuticals Co.,Ltd · next primary completion Jun 2028
  • 1Tinengotinib · TransThera Sciences (Nanjing), Inc. · next primary completion Dec 2029
  • 1Sonesitatug vedotin · AstraZeneca · next primary completion Aug 2029
Reaching primary completion within a year · 22, 5 in phase 3

Studies that test Leucovorin, phase 3 first.

Studies

Open first, then newest update. How each study uses Leucovorin is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 310

See all 310 studies that test Leucovorin →

Given beside what is tested · 594 — Leucovorin is usual care or a partner of the new treatment

Showing 20 of 594.

As the comparator · 47 — what is tested is compared with Leucovorin

Showing 20 of 47.

Codes

What other systems call Leucovorin · ClinicalTrials.gg INT007224

  • MeSH (NLM) D002955LeucovorinConfirmed ClinicalTrials.gov, NLM
  • UNII (FDA) Q573I9DVLPLEUCOVORINConfirmed FDA, NLM
  • RxNorm 6313One source FDA
  • NCI Thesaurus C71631LeucovorinOne source FDA

Also registered as leucovorin calcium (UNII RPR1R4C0P4 · RxNorm 225852) and leucovorin calcium pentahydrate (UNII R3W57OBQ5W).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.