Carcinoma, Hepatocellular clinical trials
The registry lists 3,650 studies for Carcinoma, Hepatocellular across more than 10 countries. 1,062 are recruiting or about to start. 3,068 of them are mainly about Carcinoma, Hepatocellular (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Fibrolamellar hepatocellular carcinoma too: 3,663 studies, 1,065 open.
ClinicalTrials.gov finds 4,061 studies for Carcinoma, Hepatocellular. How that becomes 3,646 here
This page counts the studies the registry files under Carcinoma, Hepatocellular, and those it files under no condition that list Carcinoma, Hepatocellularthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 4,061Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −13Filed under a narrower condition, counted on its own pageFibrolamellar hepatocellular carcinoma 13
- −35List Carcinoma, Hepatocellular as a condition, but the registry did not file them under itMost often written as “Advanced Hepatocellular Carcinoma” (12), “Unresectable Hepatocellular Carcinoma” (5), and “Childhood Hepatocellular Carcinoma” (2). The registry filed them under other conditions only, most often Liver Neoplasms (17) and Carcinoma (5).
- −367Match it another way266 name it in the title, 3 in a keyword, and 98 by a synonym or other text the search reads.
- 3,646The count on this page266 of them list Carcinoma, Hepatocellular in their own words; the registry filed them under no condition.
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A study of drug A after surgery for early breast cancer
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Changed
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· Enrollment: 300 → 450 participants
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Status
Who runs them
Sun Yat-sen University (185) · National Cancer Institute (NCI) (75) · Shanghai Zhongshan Hospital (63) · Seoul National University Hospital (61) · Eastern Hepatobiliary Surgery Hospital (51) · Fudan University (48) · National Taiwan University Hospital (44) · Tianjin Medical University Cancer Institute and Hospital (43)
What is being tested here
Drugs under test in Carcinoma, Hepatocellular studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lenvatinib | 48 | 17 | 101 |
| Sintilimab | 24 | 6 | 44 |
| Bevacizumab | 23 | 12 | 63 |
| Durvalumab | 20 | 5 | 40 |
| Tislelizumab | 20 | 4 | 34 |
| Atezolizumab | 15 | 11 | 37 |
| Tremelimumab | 14 | 5 | 33 |
| Camrelizumab | 12 | 5 | 33 |
| Apatinib | 12 | 7 | 32 |
| Iparomlimab/Tuvonralimab | 12 | 1 | 12 |
Drug classes tested here Immune checkpoint inhibitors 169 open · Tyrosine kinase inhibitors (TKIs) 96 open · Angiogenesis inhibitors 23 open · Antimetabolites 10 open · Alkylating agents 4 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026The Impact on Survival of Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma And Portal Vein Tumor Thrombosis (PVTT) Who Underwent Hepatectomy : A Random, Controlled, Stage III Clinical Trial. · Phase 3 · Sun Yat-sen University
- Dec 2026A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride Capsules Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC) · Phase 3 · Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Dec 2026Hepatectomy Combined With Camrelizumab and Apatinib in CNLC Stage IIIb HCC · Phase 3 · Guangxi Medical University
- Dec 2026Toripalimab or Placebo as Adjuvant Therapy in Hepatocellular Carcinoma After Radical Resection · Phase 3 · Shanghai Junshi Bioscience Co., Ltd.
- Dec 2026Paediatric Hepatic International Tumour Trial · Phase 3 · University of Birmingham
- Dec 2026Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis · Phase 3 · VA Office of Research and Development
- Dec 2026Phase III Study of Toripalimab(JS001) Combined With Lenvatinib for Advanced HCC · Phase 3 · Shanghai Junshi Bioscience Co., Ltd.
- Jan 2027A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC) · Phase 3 · AbbVie
- Feb 2027SBRT Plus Lenvatinib and TACE for Advanced Primary HCC: A Phase 3 Trial (SEARCH) · Phase 3 · Sun Yat-sen University
- May 2027Lenvatinib Combined With TACE and Camrelizumab in Conversion Resection for Advanced Hepatocellular Carcinoma (LEN-TAC Study) · Phase 3 · Wen Tianfu
Who these studies take
Of the 737 Carcinoma, Hepatocellular studies recruiting now, 382 (52%) set no upper age limit and 249 (34%) stop at 75 or younger. 31 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 31 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 28 (4%) | 28 (4%) |
| 18 | 683 (93%) | 683 (93%) |
| 30 | 726 (99%) | 726 (99%) |
| 40 | 726 (99%) | 726 (99%) |
| 50 | 727 (99%) | 727 (99%) |
| 65 | 723 (98%) | 723 (98%) |
| 75 | 681 (92%) | 681 (92%) |
| 85 | 428 (58%) | 428 (58%) |
Across all 3,650 studies, recruiting or not: 29% stop at 75 or younger and 3% at 65; 6% take children; <1% are for women only and <1% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Carcinoma, Hepatocellular studies take
Of 428 phase 2 interventional studies under Carcinoma, Hepatocellular, half reached primary completion within 43 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 49 mo32–77 · 248 studies | 47 mo29–65 · 103 studies | 51 mo33–80 · 145 studies |
| Phase 1/2 | 53 mo38–76 · 136 studies | 47 mo35–74 · 72 studies | — |
| Phase 2 | 43 mo30–71 · 428 studies | 38 mo23–50 · 80 studies | 47 mo33–78 · 348 studies |
| Phase 3 | 56 mo43–83 · 138 studies | 53 mo41–63 · 52 studies | 70 mo49–109 · 86 studies |
| Phase 4 | 68 mo24–118 · 38 studies | — | — |
| Interventional, no phase | 47 mo23–75 · 384 studies | — | 48 mo24–76 · 360 studies |
| Observational | 51 mo32–108 · 352 studies | 41 mo24–58 · 49 studies | 54 mo35–114 · 303 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting6
- Multimodal Liquid-Biopsy Omics Biomarkers of Treatment Response in Breast CancerNov 12, 2026NCT07880106
- Epalrestat Combined With HAIC, Donafenib and Tislelizumab as First-line Treatment for Patients With Unresectable HCC and DiabetesNov 10, 2026NCT07557914
- Peripheral Blood Biomarkers and Response to Atezolizumab Plus Bevacizumab in Hepatocellular CarcinomaNov 10, 2026NCT07734857
- Study Comparing BGB-B2033 With Sorafenib or Lenvatinib in Advanced Hepatocellular CarcinomaNov 10, 2026NCT07836530
- DNP-MRSI of HCC Metabolism to Predict Therapeutic ResponseNov 2, 2026NCT07807475
Show 1 moreShow fewer
- 68Ga-NYM207 PET/CT Imaging in Hepatocellular CarcinomaOct 21, 2026NCT07590336
Results posted5
- Composition for Treating Cirrhosis and Liver Cancer (SB-1121)Nov 6, 2026NCT05178303
- Sorafenib Tosylate Following a Liver Transplant in Treating Patients With Liver CancerNov 3, 2026NCT01624285
- Radiation Therapy With Protons or Photons in Treating Patients With Liver CancerNov 3, 2026NCT03186898
- Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular CarcinomaOct 28, 2026NCT04658147
- A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver CancerOct 14, 2026NCT05337137
Stopped5
- Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid TumorsTerminatedNov 10, 2026NCT05075993
- KAT-101 in Subjects With Hepatocellular Carcinoma (HCC)TerminatedOct 27, 2026NCT05603572
- A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in Combination With Budigalimab Moves Through the Bodies of Adult Chinese Participants With Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC)TerminatedOct 21, 2026NCT06487559
- A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor NaiveTerminatedOct 20, 2026NCT05879822
- SBRT Plus Systemic Therapy vs Systemic Therapy Alone in BCLC C Hepatocellular CarcinomaSuspendedOct 15, 2026NCT07274774
Newly registered16
- Retrospective Analysis of a Psoralea Corylifolia (Buguzhi)-Containing TCM Formula for Gastrointestinal CancersNov 12, 2026NCT07932951
- QL1706 and Lenvatinib Combined With FOLFOX Systemic Chemotherapy as Second-line Treatment in Advanced Hepatocellular Carcinoma PatientsNov 12, 2026NCT07933016
- INPACT: Implementation of Nutritional Support and Physical Activity During Cancer TreatmentNov 10, 2026NCT07929597
- Transarterial Chemoembolization (TACE) and Stereotactic Body Radiation (SBRT) in Patients With Hepatocellular Carcinoma (HCC) Prior to Liver TransplantationNov 9, 2026NCT07924943
- NIVO+IPI Neoadjuvant Therapy for Recurrent Resectable HCCNov 5, 2026NCT07919717
Show 11 moreShow fewer
- Characterizing Tumor Hypoxia With BOLD-MRI to Predict Y-90 Treatment ResponseNov 4, 2026NCT07916376
- A Clinical Study Evaluating the Safety and Efficacy of Ivonescimab as Second-line Treatment in Patients With Advanced Hepatocellular CarcinomaNov 4, 2026NCT07917481
- Study Evaluating the Efficacy and Safety of BGB-B2033 in Participants With Advanced Hepatocellular CarcinomaNov 3, 2026NCT07911683
- Immune-Related Adverse Events and Clinical Outcomes of First-Line Immunotherapy in Egyptian Patients With Unresectable Hepatocellular CarcinomaOct 29, 2026NCT07904494
- Overcoming Immunotherapy Resistance in Hepatocellular CarcinomaOct 26, 2026NCT07895342
- Personalized Adaptive Radiotherapy for Hepatocellular CarcinomaOct 26, 2026NCT07895732
- PULSAR Radiotherapy Combined With Immunotherapy for High-Risk Advanced Liver CancerOct 21, 2026NCT07884877
- SBRT Combined With Iparomlimab and Tuvonralimab (QL1706) and Bevacizumab for Hepatocellular CarcinomaOct 20, 2026NCT07882056
- Multimodal Liquid-Biopsy Omics Biomarkers of Treatment Response in Breast CancerOct 19, 2026NCT07880106
- Estimating The Rate Of Complete Ablation (A0) With The Use Of Biomechanical Deformable Image RegistrationOct 16, 2026NCT07877220
- Study of Tegavivint Plus Zanzalintinib in Patients With Advanced Hepatocellular CarcinomaOct 16, 2026NCT07878689
Studies
Recruiting first, then most recently updated. Showing 50 of 3,650. Browse all 3,650 → or search them.
- Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open HepatectomyRecruitingNCT04982653Phase 21 country
- Multimodal Liquid-Biopsy Omics Biomarkers of Treatment Response in Breast CancerRecruitingNCT078801061 country
- High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver MalignanciesRecruitingNCT05053555Not applicable1 country
- Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning ModelRecruitingNCT06420440Phase 21 country
- QL1706 and Lenvatinib Combined With FOLFOX Systemic Chemotherapy as Second-line Treatment in Advanced Hepatocellular Carcinoma PatientsNot yet recruitingNCT07933016Phase 2
- TheraBionic P1 Device in Subjects With Advanced Hepatocellular CarcinomaRecruitingNCT07118202Not applicable1 country
- Goal-directed LCVP Based on HP in Laparoscopic HepatectomyRecruitingNCT05887661Not applicable1 country
- A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid MalignanciesRecruitingNCT07197554Phase 11 country
- Epalrestat Combined With HAIC, Donafenib and Tislelizumab as First-line Treatment for Patients With Unresectable HCC and DiabetesRecruitingNCT07557914Phase 21 country
- A Study of Therapeutic Drug Monitoring-Based Atezolizumab DosingRecruitingNCT06066138Phase 11 country
- Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 FailureRecruitingNCT07219459Phase 27 countries
- INPACT: Implementation of Nutritional Support and Physical Activity During Cancer TreatmentNot yet recruitingNCT07929597Not applicable1 country
- Peripheral Blood Biomarkers and Response to Atezolizumab Plus Bevacizumab in Hepatocellular CarcinomaRecruitingNCT077348571 country
- Study Comparing BGB-B2033 With Sorafenib or Lenvatinib in Advanced Hepatocellular CarcinomaRecruitingNCT07836530Phase 32 countries
- Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing PancreatectomyNot yet recruitingNCT07608458Not applicable1 country
- Transarterial Chemoembolization (TACE) and Stereotactic Body Radiation (SBRT) in Patients With Hepatocellular Carcinoma (HCC) Prior to Liver TransplantationRecruitingNCT07924943Not applicable1 country
- Effect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular CarcinomaRecruitingNCT07189624Not applicable1 country
- The Vanguard Study: Testing a New Way to Screen for CancerRecruitingNCT06995898Not applicable1 country
- Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)RecruitingNCT064864541 country
- A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical PracticeRecruitingNCT072841218 countries
- NIVO+IPI Neoadjuvant Therapy for Recurrent Resectable HCCNot yet recruitingNCT07919717Phase 21 country
- A Clinical Study Evaluating the Safety and Efficacy of Ivonescimab as Second-line Treatment in Patients With Advanced Hepatocellular CarcinomaNot yet recruitingNCT07917481Phase 2
- Characterizing Tumor Hypoxia With BOLD-MRI to Predict Y-90 Treatment ResponseNot yet recruitingNCT07916376Not applicable1 country
- Integration of Imaging, Molecular, Pathological, and Clinical Outcome Data in Hepatocellular Carcinoma.Not yet recruitingNCT079128531 country
- A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid TumorsRecruitingNCT07636785Phase 1/21 country
- Study Evaluating the Efficacy and Safety of BGB-B2033 in Participants With Advanced Hepatocellular CarcinomaNot yet recruitingNCT07911683Phase 2
- PEARL Trial: Partial TACE Enhancing Anti-tumor Response With Lenvatinib in Unresectable HCCNot yet recruitingNCT07827807Phase 2
- Targeted Navigation in Hepatocellular Carcinoma (HCC)RecruitingNCT06260943Not applicable1 country
- DNP-MRSI of HCC Metabolism to Predict Therapeutic ResponseRecruitingNCT078074751 country
- Improving Hepatocellular Carcinoma ScreeningRecruitingNCT05828446Not applicable1 country
- A Post Approval Study to Evaluate Safety and Effectiveness of Multicompartmental Dosimetry Planning.Not yet recruitingNCT07669727
- DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid TumorsRecruitingNCT06953089Phase 24 countries
- 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer DetectionRecruitingNCT06503146Phase 21 country
- Immune-Related Adverse Events and Clinical Outcomes of First-Line Immunotherapy in Egyptian Patients With Unresectable Hepatocellular CarcinomaNot yet recruitingNCT079044941 country
- A Study of TACE in Combination With SHR-8068, Adebrelimab, and Bevacizumab Versus TACE in Participants With Incurable Hepatocellular CarcinomaNot yet recruitingNCT07691762Phase 31 country
- A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 13 countries
- Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored StudyEnrolling by invitationNCT07620574Phase 31 country
- Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial HepatectomyRecruitingNCT06681818Not applicable1 country
- Study of ACC-1898 in Adult Participants With Advanced Solid TumorsNot yet recruitingNCT07252661Phase 1
- A Study to Evaluate ALN-BCAT in Patients With Hepatocellular CarcinomaRecruitingNCT06600321Phase 13 countries
- A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)RecruitingNCT06330064Phase 1/218 countries
- ENPP1/cGAS (EG) and FAP Expression Profiles in Solid Tumors: An Immunohistochemical Study in a Vietnamese CohortRecruitingNCT078081641 country
- Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular CarcinomaRecruitingNCT04472767Phase 21 country
- Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.RecruitingNCT04587739Phase 11 country
- Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE TrialRecruitingNCT06811116Phase 1/21 country
- Overcoming Immunotherapy Resistance in Hepatocellular CarcinomaNot yet recruitingNCT07895342Not applicable1 country
- Personalized Adaptive Radiotherapy for Hepatocellular CarcinomaNot yet recruitingNCT07895732Phase 31 country
- A Phase 1 Study of the Safety and Tolerability of CTX-10726RecruitingNCT07419841Phase 11 country
- A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)RecruitingNCT07291076Phase 1/214 countries
- Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver CancerRecruitingNCT07042919Phase 1/21 country