Drug
Isoniazid clinical trials
Also written INH and Isonicotinic Acid Hydrazide.
- studies test it
- 94
- open now
- 10
- in phase 3
- 30
- first study started
- 1995
Keep track of what changes. Save the Isoniazid studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Other names
Studies by the year they started
93 studies that test it; most in 2020 (11)
| Year | Studies |
|---|---|
| 1995 | 2 |
| 1996 | 1 |
| 1999 | 1 |
| 2001 | 2 |
| 2002 | 1 |
| 2003 | 1 |
| 2004 | 5 |
| 2005 | 1 |
| 2006 | 1 |
| 2007 | 3 |
| 2008 | 4 |
| 2009 | 2 |
| 2010 | 2 |
| 2011 | 3 |
| 2012 | 2 |
| 2013 | 3 |
| 2014 | 2 |
| 2015 | 6 |
| 2016 | 5 |
| 2017 | 3 |
| 2018 | 2 |
| 2019 | 6 |
| 2020 | 11 |
| 2021 | 3 |
| 2022 | 6 |
| 2023 | 8 |
| 2024 | 4 |
| 2025 | 2 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 15
- Phase 2
- 25
- Phase 3
- 30
- Phase 4
- 20
- No phase
- 14
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 91
National Institute of Allergy and Infectious Diseases (NIAID) (10) · Aswan University Hospital (8) · Centers for Disease Control and Prevention (6) · University of Cape Town (5) · National Taiwan University Hospital (4) · Instituto Nacional de Salud Publica, Mexico (4) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (3) · Huashan Hospital (3)
Often tested with
Tested in the same studies.
Rifampin (28) · Pyrazinamide (21) · Ethambutol (18) · Rifapentine (14) · Moxifloxacin (7) · Levofloxacin (4) · Pyridoxine (4) · Linezolid (3)
Studies
Open first, then newest update. How each study uses Isoniazid is read from its arms, and is right about nine times in ten.
Testing it · 94
- Re-evaluating the Duration in Children of TB TreatmentNot yet recruitingPhase 2University of Wisconsin, MadisonNCT07656012Written as Isoniazid
- A Phase I Study Investigating the Local Tolerability and Pharmacokinetics of Isoniazid (INH) Inhalation by Wet Nebulization in Patients With TuberculosisRecruitingPhase 1University Medical Center GroningenNCT07708779Written as Isoniazid
- A Novel Therapy With a 1-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB-YOUTH Study)RecruitingPhase 3Huashan HospitalNCT06022146Written as isoniazid and rifapentine
- Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous MeningitisRecruitingPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT05383742Written as Isoniazid (INH)
- PanACEA - STEP2C -01RecruitingPhase 2Michael HoelscherNCT05807399Written as Isoniazid
- Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)Not yet recruitingPhase 3University College, LondonNCT07163143Written as Isoniazid (H)
- Safety of Administering Isoniazid to SLE Patients to Prevent TBRecruitingPhase 2/3Universitas PadjadjaranNCT06618573Written as Isoniazid/Pyridoxine
- Short-course Rifamycin-based Regimens for Latent Tuberculosis in Patients With End-stage Kidney DiseaseNot yet recruitingPhase 4Miguel SantínNCT05021731Written as Rifampicin plus Isoniazid
- Intensified Short Course Regimen for TBM in AdultsNot yet recruitingPhase 3Indian Council of Medical ResearchNCT05917340Written as Isoniazid
- Preventive Treatment Of Latent Tuberculosis Infection In People With Diabetes MellitusRecruitingPhase 3Dr. Nyanda Elias NtinginyaNCT04600167Written as Isoniazid and Rifapentine (INH-RPT)
- Tuberculosis Treatment Shortening TrialCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00130247Written as Isoniazid
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAMCompletedPhase 3Queen Mary University of LondonNCT05994742Written as Isoniazid
- Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and PyrazinamideSuspendedPhase 2University Hospital, LinkoepingNCT04694586Written as HRZE
- Tuberculosis Clinical Trials Consortium Study 35CompletedPhase 1/2Centers for Disease Control and PreventionNCT03730181Written as Isoniazid
- Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary TuberculosisActive, not recruitingPhase 2Global Alliance for TB Drug DevelopmentNCT06058299Written as HRZE
- Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary TuberculosisCompletedPhase 2GlaxoSmithKlineNCT05382312Written as RIFAFOUR e-275
- Point-of-care Pharmacogenomic Testing to Optimize Isoniazid Dosing for Tuberculosis PreventionCompletedPhase 1Stanford UniversityNCT05413551Written as Low-dose isoniazid
- Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in BotswanaCompletedPhase 4Centers for Disease Control and PreventionNCT00164281Written as Isoniazid
- Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary TuberculosisTerminatedPhase 2Gates Medical Research InstituteNCT05971602Written as Isoniazid, Rifampicin, Pyrazinamide, Ethambutol (HRZE)
- Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated TuberculosisActive, not recruitingPhase 3University of Cape TownNCT04951986Written as Rifampicin, Pyrazinamide, Ethambutol and Isoniazid
See all 94 studies that test Isoniazid →
Given in every arm · 30 — Isoniazid is usual care beside what is tested
- Trial of Novel Regimens for the Treatment of Pulmonary TuberculosisRecruitingPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT06192160Written as Isoniazid
- A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIVRecruitingPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT07124559Written as Isoniazid
- A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB)Not yet recruitingPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT07595042Written as Isoniazid
- Shortened Regimen for Drug-susceptible TB in ChildrenRecruitingPhase 3Johns Hopkins UniversityNCT06253715Written as Isoniazid
- Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible TuberculosisNot yet recruitingPhase 2Shanghai Pulmonary Hospital, Shanghai, ChinaNCT07129629Written as Isoniazid (H)
- Short-Course Anti-tuberculosis Regimens for Mild Spinal TuberculosisNot yet recruitingPhase 2Shandong UniversityNCT06917495Written as Isoniazid
- Sitafloxacin-containing Regimens for Shortening Tuberculosis TreatmentNot yet recruitingPhase 3First Affiliated Hospital of Zhejiang UniversityNCT05454345Written as Isoniazid
- Treatment Shortening of Drug-Sensitive Pulmonary Tuberculosis Using High Dose Rifampicin (Hi-DoRi-3)Not yet recruitingPhase 3Seoul National University HospitalNCT04485156Written as Isoniazid
- 1HP Versus 3HR in the Treatment of Tuberculosis Infection in VietnamWithdrawnPhase 3Freundeskreis Für Internationale Tuberkulosehilfe e.VNCT06191692Written as Isoniazid
- Pharmacokinetic and Pharmacodynamic Study of High-Dose Rifapentine and Moxifloxacin for Treatment of TuberculosisCompletedPhase 3Centers for Disease Control and PreventionNCT02563327Written as Isoniazid
- Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)CompletedPhase 2University of Massachusetts, WorcesterNCT04930744Written as Isoniazid
- Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST StudyTerminatedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT04311502Written as Isoniazid
- Addiction, HIV and Tuberculosis in Malaysian Criminal Justice SettingsCompletedNot applicableYale UniversityNCT03089983Written as Isoniazid
- Study 33: Adherence to Latent Tuberculosis Infection Treatment 3HP SAT Versus 3HP DOTCompletedPhase 3Centers for Disease Control and PreventionNCT01582711Written as isoniazid and rifapentine
- Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected IndividualsTerminatedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT04272242Written as Isoniazid (INH)
- Treatment of Latent Tuberculosis in Socially Marginalised CitizensTerminatedPhase 4Aarhus University HospitalNCT03266991Written as Isoniazid
- StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With TuberculosisCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT03882177Written as Rifafour
- Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive TuberculosisCompletedPhase 2/3University College, LondonNCT03474198Written as Isoniazid
- Assessing PA-824 for Tuberculosis (the APT Trial)CompletedPhase 2Johns Hopkins UniversityNCT02256696Written as Isoniazid
- A Randomised Trial to Evaluate Toxicity and Efficacy of 1200mg and 1800mg Rifampicin for Pulmonary TuberculosisCompletedPhase 3St George's, University of LondonNCT02581527Written as Isoniazid
Showing 20 of 30.
As the comparator · 31 — what is tested is compared with Isoniazid
- Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TBRecruitingPhase 2/3Johns Hopkins UniversityNCT06568484Written as Isoniazid, rifapentine
- Platform Assessing Regimens and Durations In a Global Multisite Consortium for TBRecruitingPhase 2University College, LondonNCT06114628Written as Isoniazid (H)
- Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis MeningitisNot yet recruitingPhase 2BioVersys AGNCT07350174Written as HRZE
- A PAN-USR TB Multi-Center TrialRecruitingPhase 3Shenzhen Third People's HospitalNCT06905522Written as Isoniazid (H)
- Ultra-Short Regimen for Elderly DS-TBNot yet recruitingPhase 3Shenzhen Third People's HospitalNCT07076225Written as Isoniazid (H)
- Short-course Regimens for the Treatment of Pulmonary TuberculosisActive, not recruitingPhase 2/3Centers for Disease Control and PreventionNCT05766267Written as Isoniazid
- BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)CompletedPhase 1/2Michael HoelscherNCT04044001Written as Rifafour e-275®
- Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult PatientsCompletedPhase 2/3Global Alliance for TB Drug DevelopmentNCT03338621Written as HRZE
- Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TBCompletedPhase 2Otsuka Pharmaceutical Development & Commercialization, Inc.NCT05221502Written as RHEZ
- Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TuberculosisActive, not recruitingPhase 2Brigham and Women's HospitalNCT05556746Written as Isoniazid (INH)
- TBTC Study 26 PK: Rifapentine Pharmacokinetics in Children During Treatment of Latent TB InfectionCompletedNot applicableCenters for Disease Control and PreventionNCT00164450Written as Isoniazid
- A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Eto Alone and in Combination With BVL-GSK098CompletedPhase 2TASK Applied ScienceNCT05473195Written as Isoniazid 300 MG
- A Pan-TB Regimen Targeting Host and MicrobeActive, not recruitingPhase 2/3The Aurum Institute NPCNCT05686356Written as Rifafour
- Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of CareCompletedPhase 3Wits Health Consortium (Pty) LtdNCT04062201Written as Isoniazid Oral Product
- Early Bactericidal Activity of TBA-7371 in Pulmonary TuberculosisCompletedPhase 2Bill & Melinda Gates Medical Research InstituteNCT04176250Written as HRZE
- An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary TuberculosisCompletedPhase 2GlaxoSmithKlineNCT03557281Written as Rifafour e-275
- Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary TuberculosisCompletedPhase 2TASK Applied ScienceNCT05896930Written as Rifafour e-275
- Efficacy of HUEXC030 in Subjects With Pulmonary TuberculosisCompletedPhase 2/3Orient Pharma Co., Ltd.NCT02467608Written as HRZE
- Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTBCompletedPhase 2TASK Applied ScienceNCT04629378Written as Rifafour
- Phase 2a Study of PBTZ169TerminatedPhase 2Nearmedic Plus LLCNCT03334734Written as Isoniazid
Showing 20 of 31.
Codes
What other systems call Isoniazid · ClinicalTrials.gg INT007692
- MeSH (NLM) D007538IsoniazidConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) V83O1VOZ8LISONIAZIDConfirmed FDA, NLM, Wikidata
- RxNorm 6038Confirmed FDA, Wikidata
- Wikidata Q423169isoniazidConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C600IsoniazidOne source FDA
- DrugBank DB00951One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D007538 | Isoniazid | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | V83O1VOZ8L | ISONIAZID | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6038 | — | Confirmed FDA, Wikidata |
| Wikidata | Q423169 | isoniazid | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C600 | Isoniazid | One source FDA |
| DrugBank | DB00951 | — | One source Wikidata |
Also registered as ftivazide (UNII 40Q4C3O4V0).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.