Severe Acute Malnutrition clinical trials
The registry lists 82 studies for Severe Acute Malnutrition across more than 10 countries. 11 are recruiting or about to start. 58 of them are mainly about Severe Acute Malnutrition (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Kwashiorkor too: 119 studies, 16 open.
Get an email when these change. Save the Severe Acute Malnutrition studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
International Centre for Diarrhoeal Disease Research, Bangladesh (9) · Washington University School of Medicine (7) · Epicentre (7) · University of California, San Francisco (4) · The Hospital for Sick Children (4) · International Food Policy Research Institute (4) · Action Against Hunger USA (3) · Action Contre la Faim (3)
What is being tested here
Drugs under test in Severe Acute Malnutrition studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau · Trustees of Dartmouth College
- Jan 2027Choline to Improve Malnutrition and Enhance Cognition · Washington University School of Medicine
- Mar 2027Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya · International Food Policy Research Institute
- Aug 2027The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis · Chishala Chabala
- Sep 2027Safety Trial of F-60 Among Children Hospitalized With SAM · International Centre for Diarrhoeal Disease Research, Bangladesh
Who these studies take
Of the 7 Severe Acute Malnutrition studies recruiting now, 0 (0%) set no upper age limit and 7 (100%) stop at 75 or younger. 7 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (43%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (14%) | 1 (14%) |
| 18 | 0 (0%) | 0 (0%) |
| 30 | 0 (0%) | 0 (0%) |
| 40 | 0 (0%) | 0 (0%) |
| 50 | 0 (0%) | 0 (0%) |
| 65 | 0 (0%) | 0 (0%) |
| 75 | 0 (0%) | 0 (0%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 82 studies, recruiting or not: 100% stop at 75 or younger and 100% at 65; 99% take children; 0% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Severe Acute Malnutrition studies take
Of 32 interventional studies with no phase under Severe Acute Malnutrition, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo11–25 · 32 studies | — | 19 mo11–25 · 32 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 82. Browse all 82 → or search them.
- Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in EthiopiaRecruitingNCT06380504Not applicable1 country
- The Relapse to Acute Malnutrition Prevention (RAMP) TrialNot yet recruitingNCT07871955Not applicable1 country
- Safety Trial of F-60 Among Children Hospitalized With SAMEnrolling by invitationNCT07752628Not applicable1 country
- The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood TuberculosisRecruitingNCT06593080Not applicable1 country
- Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in KenyaNot yet recruitingNCT07420062Not applicable1 country
- Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in KenyaRecruitingNCT07315295Not applicable2 countries
- Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute MalnutritionRecruitingNCT06010719Phase 41 country
- Management of Shock in Children With SAM or Severe Underweight and DiarrheaRecruitingNCT04750070Phase 31 country
- Modified Dosage for Severe Acute MalnutritionRecruitingNCT06061484Not applicable1 country
- Family Mid-Upper Arm Circumference (MUAC) Follow-up After Recovery From Acute Malnutrition (MODAM-fMUAC)RecruitingNCT06038071Not applicable1 country
- Microbiota Directed Food for Children With Severe Acute MalnutritionNot yet recruitingNCT06308848Not applicable1 country
- Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in KenyaCompletedNCT06441305Not applicable1 country
- Severe Acute Malnutrition and Child Development Clinical Trial in MwanzaCompletedNCT06781918Phase 31 country
- Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute MalnutritionActive, not recruitingNCT06869850Not applicable1 country
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAMCompletedNCT05994742Phase 33 countries
- Choline to Improve Malnutrition and Enhance CognitionActive, not recruitingNCT06154174Not applicable1 country
- Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute MalnutritionCompletedNCT05932992Not applicable1 country
- Regular Growth Monitoring (RGM) of Young Children in Guinea-BissauActive, not recruitingNCT07584395Not applicable1 country
- Evaluating RISQ System Implementation in Acutely Malnourished Children in Chad (CRIMSON)CompletedNCT06123390Not applicable1 country
- Alternative RUTFs for Treatment of Child WastingCompletedNCT06912620Phase 31 country
- Efficacy of Striatin in Malnourished ChildrenCompletedNCT07089329Phase 31 country
- Slow Introduction of Nutrition for Ill Malnourished ChildrenActive, not recruitingNCT06846749Phase 12 countries
- Development of a Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition (TB-Speed SAM)CompletedNCT04240990Not applicable2 countries
- RECIPE BASED F100 INTERVENTION FOR NUTRITIONAL EFFICACY IN SAM (REFINE-SAM )CompletedNCT07130877Not applicable1 country
- Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)CompletedNCT07070856Not applicable1 country
- Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)CompletedNCT049729032 countries
- Azithromycin for Severe Acute Malnutrition in CMAM, NigeriaTerminatedNCT05473234Phase 31 country
- Eggs for Gut HealthCompletedNCT06002438Not applicable1 country
- Local Dishes Versus Ready-to-use Therapeutic Foods Management of Severe Acute MalnutritionCompletedNCT06759883Phase 21 country
- Synbiotics for the Management of Malnutrition (Children)CompletedNCT06722404Not applicable1 country
- Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort ResearchCompletedNCT062878271 country
- Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Democratic Republic of CongoCompletedNCT03751475Not applicable1 country
- Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic TrialCompletedNCT06594341Phase 41 country
- Performance of Mid-Upper Arm Circumference for Detection of Severe Acute Malnutrition in Indonesian Under-FivesCompletedNCT065452401 country
- Trial of High-Dose Vitamin D in the Treatment of Complicated Severe Acute MalnutritionCompletedNCT04270643Phase 21 country
- Rice Bran-based Supplemental Foods for the Treatment of Childhood MalnutritionCompletedNCT05319717Phase 21 country
- High-protein Quantity and Quality RUTF in Improving Linear Growth Among Children With Severe WastingCompletedNCT05737472Not applicable1 country
- Management of Severe Acute Malnutrition in SCD, in Northern NigeriaCompletedNCT03634488Phase 22 countries
- The TISA Trial - SenegalCompletedNCT04667767Not applicable1 country
- Dietary Rehabilitation in Severely Acutely Malnourished ChildrenCompletedNCT050098231 country
- Effectiveness of Alternative Diets During the Stabilization Phase on Children With Complicated SAMCompletedNCT05020847Not applicable1 country
- Effectiveness of Four Transition Dietary Regimens in the Hospital Management of Children With Kwashiorkor.CompletedNCT05015257Not applicable1 country
- Changes in Nerve Electro Physiologic Properties in Children Before and After Correction of MalnutritionCompletedNCT05891457Not applicable1 country
- Simplified Treatment Protocol for Acute Malnutrition in VenezuelaTerminatedNCT055437591 country
- Effectiveness Trial of Locally Developed Ready to Use Therapeutic FoodStatus unknownNCT05520879Not applicable1 country
- Efficacy and Acceptability of RUTFs in IndonesiaCompletedNCT05614505Not applicable1 country
- Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Niger (OptIMA Niger)CompletedNCT04698070Not applicable1 country
- IL6&8 in Malnourished Children With Acute DiarrheaStatus unknownNCT051837891 country
- Azithromycin for Uncomplicated Severe Acute Malnutrition in Burkina Faso (Pilot)CompletedNCT03568643Phase 31 country
- Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive DevelopmentCompletedNCT03094247Not applicable1 country