Tuberculosis, Multidrug-Resistant clinical trials
The registry lists 132 studies for Tuberculosis, Multidrug-Resistant across more than 10 countries. 25 are recruiting or about to start. 88 of them are mainly about Tuberculosis, Multidrug-Resistant (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Extensively Drug-Resistant Tuberculosis too: 133 studies, 25 open.
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Who runs them
Global Alliance for TB Drug Development (9) · Otsuka Pharmaceutical Development & Commercialization, Inc. (7) · Huashan Hospital (7) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · Medecins Sans Frontieres, Netherlands (5) · Foundation for Innovative New Diagnostics, Switzerland (5) · Beijing Chest Hospital (5) · Boston University (4)
What is being tested here
Drugs under test in Tuberculosis, Multidrug-Resistant studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Nov 2026Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients · Phase 3 · National Institute of Allergy and Infectious Diseases (NIAID)
- Dec 2026Innovating(IN) Shorter(S), All- Oral, Precised(P), Individualized(I) Treatment Regimen(RE) for Rifampicin Resistant Tuberculosis(INSPIRE-TB) · Phase 3 · Huashan Hospital
- Feb 2027Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis:BDLL Chinese Cohort · Phase 3 · Huashan Hospital
- Nov 2026Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region · Centre de Recherche Médicale de Lambaréné
- Jan 2027Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis · University of California, San Francisco
- Feb 2027Acetohydroxamic Acid Combined With a Short-Course Regimen for MDR-TB (AHA-PLUS) · Shanghai Pulmonary Hospital, Shanghai, China
- Apr 2027An Adaptive Randomized Controlled Trial · Columbia University
- May 2027Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB · Boston University
- Jun 2027Bioneer Q-RFIA Clinical Evaluation · Foundation for Innovative New Diagnostics, Switzerland
- Oct 2027Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis Treatment · Marco Schiuma
Who these studies take
Of the 20 Tuberculosis, Multidrug-Resistant studies recruiting now, 12 (60%) set no upper age limit and 7 (35%) stop at 75 or younger. 9 (45%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (25%) | 5 (25%) |
| 18 | 19 (95%) | 19 (95%) |
| 30 | 20 (100%) | 20 (100%) |
| 40 | 20 (100%) | 20 (100%) |
| 50 | 20 (100%) | 20 (100%) |
| 65 | 19 (95%) | 19 (95%) |
| 75 | 15 (75%) | 15 (75%) |
| 85 | 13 (65%) | 13 (65%) |
Across all 132 studies, recruiting or not: 31% stop at 75 or younger and 20% at 65; 34% take children; 0% are for women only and 1% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tuberculosis, Multidrug-Resistant studies take
Of 19 observational studies under Tuberculosis, Multidrug-Resistant, half reached primary completion within 53 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 53 mo32–90 · 19 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 132. Browse all 132 → or search them.
- Training Protocol on the Natural History of TuberculosisRecruitingNCT012120031 country
- Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa RegionRecruitingNCT070178031 country
- A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary TuberculosisRecruitingNCT07209761Phase 310 countries
- Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB TreatmentRecruitingNCT05671718Not applicable1 country
- Bioneer Q-RFIA Clinical EvaluationRecruitingNCT051177885 countries
- Feasibility of the Application of a New Six-month Treatment for Multidrug-resistant Tuberculosis (MDR-TB) Patients in France (FAST-MDR)RecruitingNCT07486024Phase 31 country
- Program for Rifampicin-Resistant Disease With Stratified Medicine for TuberculosisRecruitingNCT06441006Phase 2/35 countries
- A 6-Month MDR-END Plus Regimen for Rifampicin-Resistant TuberculosisNot yet recruitingNCT07675954Phase 31 country
- An Adaptive Randomized Controlled TrialRecruitingNCT05633056Not applicable1 country
- Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis TreatmentRecruitingNCT07477119Phase 41 country
- Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant TuberculosisNot yet recruitingNCT05007795Not applicable1 country
- Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant TuberculosisRecruitingNCT06590428Not applicable1 country
- Acetohydroxamic Acid Combined With a Short-Course Regimen for MDR-TB (AHA-PLUS)Not yet recruitingNCT07393438Phase 21 country
- Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant TuberculosisRecruitingNCT05553236Not applicable1 country
- Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis:BLMZ Chinese CohortNot yet recruitingNCT07268664Phase 31 country
- A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis PatientsRecruitingNCT05824871Phase 31 country
- Novel Triple-dose Tuberculosis Retreatment RegimenRecruitingNCT04260477Phase 31 country
- Innovating(IN) Shorter(S), All- Oral, Precised(P), Individualized(I) Treatment Regimen(RE) for Rifampicin Resistant Tuberculosis(INSPIRE-TB)RecruitingNCT05081401Phase 31 country
- Evaluation of the Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis (TEDITUB)RecruitingNCT05534750Phase 21 country
- Registry on the Effectiveness and Safety of the 9-month MDR-END Treatment Regimen in Korean Patients with FQ-sensitive MDR-TB (MDR-END Registry)Not yet recruitingNCT06674291
- Hotspots, Households and Hospitals: Enhanced Drug-resistant Tuberculosis Case Finding in NamibiaRecruitingNCT050222381 country
- Clinical Study of JDB0131 Benzenesulfonate Tablets in Patients With Drug-sensitive Pulmonary TuberculosisRecruitingNCT06224036Phase 21 country
- Preventing Acquired Resistance: Strengthen TB Treatment by Adding Amikacin in the First Treatment Week of Multidrug-resistant TuberculosisRecruitingNCT05555303Phase 21 country
- A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in ChinaRecruitingNCT05306223Phase 41 country
- A Exploratory Study of Vγ2Vδ2 T Lymphocyte-based Immunotherapy for MDR-TBRecruitingNCT05493267Phase 41 country
- Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis PatientsActive, not recruitingNCT03568383Phase 313 countries
- A Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection OutcomesCompletedNCT02129244Not applicable1 country
- Linezolid Dosing Strategies in Drug-Resistant TBCompletedNCT05007821Phase 27 countries
- Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents With Pulmonary MDR-TBSuspendedNCT02354014Phase 26 countries
- Line Probe Assay Evaluation StudyCompletedNCT02984579
- Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult PatientsCompletedNCT03338621Phase 2/38 countries
- Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TBActive, not recruitingNCT03828201Phase 22 countries
- TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TBCompletedNCT00664313Phase 1/21 country
- An Evaluation of Traditional Directly Observed Therapy (DOT) and Electronic DOT for TB TreatmentCompletedNCT03266003Not applicable1 country
- Adjunctive Acetylsalicylic Acid and Ibuprofen for TuberculosisTerminatedNCT04575519Phase 22 countries
- Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary TuberculosisTerminatedNCT05971602Phase 22 countries
- Treatment of Tuberculosis Multidrug Resistance Treatment of Tuberculosis Multidrug ResistanceCompletedNCT030577561 country
- A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TBCompletedNCT02333799Phase 31 country
- Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis:BDLL Chinese CohortActive, not recruitingNCT06649721Phase 31 country
- Oral Nutritional Supplementation and Weight Changes During Therapy in Malnourished Patients With Resistant Tuberculosis: A Clinical TrialCompletedNCT07058233Not applicable1 country
- Triage Test for All Oral DR-TB Regimen (TRiAD Study)CompletedNCT051757943 countries
- Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy AdultsCompletedNCT04493671Phase 11 country
- Study of TB Lesions Obtained in Therapeutical SurgeryCompletedNCT027152711 country
- Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q)CompletedNCT03896685Phase 36 countries
- Evaluating Newly Approved Drugs for Multidrug-resistant TBCompletedNCT02754765Phase 37 countries
- An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB)CompletedNCT02365623Phase 21 country
- A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary TuberculosisCompletedNCT04179500Phase 22 countries
- Treatment Shortening of MDR-TB Using Existing and New DrugsCompletedNCT02619994Phase 21 country
- Strengthening Evidence on Optimal Multidrug-resistant Tuberculosis Treatment RegimensActive, not recruitingNCT058714893 countries
- A Study of Ultrashort PRS Regimen V in the Treatment of MDR-TBCompletedNCT05278988Phase 41 country