Trigeminal Neuralgia clinical trials
The registry lists 140 studies for Trigeminal Neuralgia across more than 10 countries. 44 are recruiting or about to start. 119 of them are mainly about Trigeminal Neuralgia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Who runs them
Beijing Tiantan Hospital (7) · Biogen (6) · Danish Headache Center (6) · Stanford University (4) · Diskapi Teaching and Research Hospital (3) · University of Minnesota (3) · University Health Network, Toronto (3) · Assiut University (3)
What is being tested here
Drugs under test in Trigeminal Neuralgia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Feb 2027An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia. · Phase 3 · Noema Pharma AG
- Nov 2026Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia Subjects · IRCCS San Raffaele
- Dec 2026Efficacy and Safety of Irregular Pulsed Radiofrequency (Sluijter-Teixera Poisson) Versus Regular Pulsed Radiofrequency to the Gasserian Ganglion for Treatment of Primary Trigeminal Neuralgia · Sohag University
- Dec 2026Observational Study on the Treatment of Trigeminal Neuralgia by Radiosurgery · Centre Hospitalier Princesse Grace
- Dec 2026Transcranial Magnetic Stimulation for Chronic Neuropathic Pain · University of California, San Francisco
- Dec 2026High-intensity Laser Therapy Versus Low Level Laser Therapy in the Treatment of Trigeminal Neuralgia · Alexandria University
- Jan 2027Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot Study · Shaukat Khanum Memorial Cancer Hospital & Research Centre
- Feb 2027OnabotulinumtoxinA for Trigeminal Neuralgia · Stanford University
- Feb 2027Emotion and Memory in Chronic Neuropathic Pain · University Health Network, Toronto
- Apr 2027Identification of Possible Trigeminal Neuralgia · University College, London
Who these studies take
Of the 27 Trigeminal Neuralgia studies recruiting now, 18 (67%) set no upper age limit and 3 (11%) stop at 75 or younger. 3 (11%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (11%) | 3 (11%) |
| 18 | 23 (85%) | 23 (85%) |
| 30 | 25 (93%) | 25 (93%) |
| 40 | 27 (100%) | 27 (100%) |
| 50 | 27 (100%) | 27 (100%) |
| 65 | 25 (93%) | 25 (93%) |
| 75 | 25 (93%) | 25 (93%) |
| 85 | 22 (81%) | 22 (81%) |
Across all 140 studies, recruiting or not: 21% stop at 75 or younger and 8% at 65; 11% take children; 1% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Trigeminal Neuralgia studies take
Of 33 interventional studies with no phase under Trigeminal Neuralgia, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 27 mo11–40 · 33 studies | — | 27 mo11–40 · 33 studies |
| Observational | 37 mo24–59 · 19 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered3
- Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot StudyNov 5, 2026NCT07919444
- Accelerated Dual-Protocol rTMS for Refractory Trigeminal NeuralgiaNov 2, 2026NCT07908420
- Twenty-five Years of Advanced RadioTherapy at San Raffaele HospitalOct 26, 2026NCT07894900
Studies
Recruiting first, then most recently updated. Showing 50 of 140. Browse all 140 → or search them.
- Trigeminal Neuralgia ElectrophysiologyRecruitingNCT052694721 country
- Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot StudyRecruitingNCT07919444Phase 21 country
- Trigeminal Evoked Responses to Improve RhizotomyRecruitingNCT05738096Early Phase 11 country
- Twenty-five Years of Advanced RadioTherapy at San Raffaele HospitalNot yet recruitingNCT078949001 country
- RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal NeuralgiaRecruitingNCT07596485Phase 1/21 country
- Ultra-Early Gamma Knife Stereotactic Radiosurgery for TNRecruitingNCT06949436Phase 21 country
- Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal NeuralgiaRecruitingNCT05152368Phase 12 countries
- Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal NeuralgiaRecruitingNCT068519101 country
- Management of Arachnoid Nerve Tethering in Trigeminal NeuralagiaNot yet recruitingNCT07811973Not applicable
- Clinical Efficacy and Peripheral Ultrasound Mechanism of Trigger Point Bloodletting Therapy for Primary Trigeminal NeuralgiaNot yet recruitingNCT07750730Not applicable1 country
- Efficacy and Safety of Oral Antiviral Therapy for Idiopathic Trigeminal NeuralgiaNot yet recruitingNCT07673549Not applicable
- High-intensity Laser Therapy Versus Low Level Laser Therapy in the Treatment of Trigeminal NeuralgiaNot yet recruitingNCT07590414Not applicable1 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- Identification of Possible Trigeminal NeuralgiaNot yet recruitingNCT074535111 country
- The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal NeuralgiaNot yet recruitingNCT06977932Not applicable
- Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia SubjectsEnrolling by invitationNCT05810428Not applicable1 country
- The Will Erwin Headache Research Center - Cluster Headache StudyRecruitingNCT029103231 country
- OnabotulinumtoxinA for Trigeminal NeuralgiaRecruitingNCT06216886Phase 41 country
- Resting-State fMRI Study of Functional Connectivity After Gamma Knife Radiosurgery in Trigeminal NeuralgiaNot yet recruitingNCT07357025Not applicable
- Efficacy and Safety of Irregular Pulsed Radiofrequency (Sluijter-Teixera Poisson) Versus Regular Pulsed Radiofrequency to the Gasserian Ganglion for Treatment of Primary Trigeminal NeuralgiaNot yet recruitingNCT07275229Not applicable
- Risk Factors for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon CompressionNot yet recruitingNCT07238244
- Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal NeuralgiaNot yet recruitingNCT072165471 country
- Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular ConflictNot yet recruitingNCT071350242 countries
- Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Peripheral Neuropathic Pain.RecruitingNCT06290661Not applicable1 country
- The Synergism and Attenuation Effects of Electroacupuncture in the Treatment of Trigeminal NeuralgiaNot yet recruitingNCT07074561Not applicable
- Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"RecruitingNCT05051072Not applicable1 country
- Comparison of Two Types of Radiofrequency Treatment for Trigeminal NeuralgiaNot yet recruitingNCT07013500Not applicable1 country
- Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal NeuralgiaRecruitingNCT06890897Not applicable1 country
- The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal NeuralgiaRecruitingNCT064723231 country
- Masseter Muscle Thickness in Gasser Ganglion Radiofrequency TreatmentRecruitingNCT06278194Not applicable1 country
- Magnetic Resonance Imaging in Patients with Trigeminal NeuralgiaNot yet recruitingNCT06853119
- Observational Study on the Treatment of Trigeminal Neuralgia by RadiosurgeryRecruitingNCT056772431 country
- Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal NeuralgiaRecruitingNCT06779578Not applicable1 country
- Comparison of Pulsed and Thermal Radiofrequency for Trigeminal NeuralgiaRecruitingNCT06684275Not applicable1 country
- Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine LesionRecruitingNCT05451251Phase 11 country
- RSSearch Patient Registry-Long Term Study of Use of SRS/SBRTRecruitingNCT018852991 country
- Emotion and Memory in Chronic Neuropathic PainRecruitingNCT065184211 country
- Pregabalin as an add-on Therapy to Carbamazepine in Trigeminal Neuralgia PatientsRecruitingNCT06357260Not applicable1 country
- Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal NeuralgiaEnrolling by invitationNCT06410859Phase 21 country
- Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal NeuralgiaRecruitingNCT06315790Phase 31 country
- Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia (FreeST Trial)RecruitingNCT05615714Phase 1/21 country
- An Follow-up Study of Occlusal Adjustment for Orofacial PainRecruitingNCT02856906Not applicable1 country
- Incidence of Intravascular (IV) Injection During Trigeminal Nerve BlocksRecruitingNCT044673981 country
- A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life and Reduce ComplicationsRecruitingNCT04117035Not applicable1 country
- Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal NeuralgiaCompletedNCT06863324Not applicable2 countries
- Accelerated Dual-Protocol rTMS for Refractory Trigeminal NeuralgiaCompletedNCT079084201 country
- Transcranial Magnetic Stimulation for Chronic Neuropathic PainActive, not recruitingNCT05593237Not applicable1 country
- CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal NeuralgiaCompletedNCT06620172Not applicable1 country
- A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal NeuralgiaActive, not recruitingNCT06213155Not applicable1 country
- MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal NeuralgiaActive, not recruitingNCT04579692Not applicable1 country