Drug
Dexrazoxane clinical trials
Also written Zinecard, Totect, ADR-529 and ICRF-187.
- studies test it
- 25
- open now
- 3
- in phase 3
- 7
- first study started
- 1996
Keep track of what changes. Save the Dexrazoxane studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
24 studies that test it; most in 2001 (4)
| Year | Studies |
|---|---|
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 1 |
| 2001 | 4 |
| 2002 | 2 |
| 2003 | 1 |
| 2009 | 3 |
| 2012 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2016 | 1 |
| 2018 | 2 |
| 2021 | 2 |
| 2024 | 1 |
| 2025 | 1 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 7
- Phase 2
- 14
- Phase 3
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 22
National Cancer Institute (NCI) (4) · Valerio Therapeutics (2) · City of Hope Medical Center (2) · Children's Oncology Group (2) · St. Jude Children's Research Hospital (1) · Rohan Dharmakumar (1) · University of Arkansas (1) · Washington University School of Medicine (1)
Often tested with
Tested in the same studies.
Doxorubicin (9) · Vincristine (4) · Irinotecan (3) · Cisplatin (3) · Ifosfamide (2) · Etoposide (2) · Cyclophosphamide (2) · Bevacizumab (1)
Studies
Open first, then newest update. How each study uses Dexrazoxane is read from its arms, and is right about nine times in ten.
Testing it · 25
- Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell LymphomaRecruitingPhase 3Stichting Hemato-Oncologie voor Volwassenen NederlandNCT06220032Written as Dexrazoxane
- The CARDIOPROTECT TrialRecruitingPhase 2Beth Israel Deaconess Medical CenterNCT07654426Written as Dexrazoxane
- Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood CancersRecruitingPhase 2M.D. Anderson Cancer CenterNCT03589729Written as Dexrazoxane Hydrochloride
- Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver CancerCompletedPhase 3National Cancer Institute (NCI)NCT00980460Written as Dexrazoxane
- Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified ChemotherapyActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT01871766Written as Dexrazoxane
- Dexrazoxane to Protect Against Hemorrhagic STEMICompletedPhase 2Rohan DharmakumarNCT07502521Written as Dexrazoxane
- Prevention of Heart Failure Induced by Doxorubicin With Early Administration of DexrazoxaneCompletedPhase 1University of ArkansasNCT03930680Written as Dexrazoxane
- Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue SarcomaCompletedPhase 2Washington University School of MedicineNCT02584309Written as Dexrazoxane
- Use of the Cardioprotectant Dexrazoxane During Congenital Heart SurgeryStatus unknownPhase 1University of Texas at AustinNCT04997291Written as Dexrazoxane
- OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma PatientsTerminatedPhase 2Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus NordwestNCT03698227Written as Dexrazoxane
- Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot InvestigationTerminatedPhase 1Medical City Children's HospitalNCT02519335Written as Dexrazoxane
- Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RTCompletedPhase 2Dana-Farber Cancer InstituteNCT00084838Written as dexrazoxane hydrochloride
- A Clinical Trial on Topotect® (Dexrazoxane) in the Treatment of Accidental Extravasation of AnthracyclinesCompletedPhase 2/3Valerio TherapeuticsNCT00548704Written as Dexrazoxane
- Efficacy of TopotectTM (Dexrazoxane) for Accidental Extravasation of AnthracyclinesCompletedPhase 2/3Valerio TherapeuticsNCT00548561Written as Dexrazoxane
- Dexrazoxane and Cisplatin in Treating Patients With Advanced Solid TumorsCompletedPhase 1City of Hope Medical CenterNCT00550901Written as dexrazoxane hydrochloride
- A Phase I/II Study of KDX-0811(Dexrazoxane) in the Treatment of Accidental Extravasation of Anthracycline Anti-cancer AgentsCompletedPhase 1/2Kissei Pharmaceutical Co., Ltd.NCT01596088Written as Dexrazoxane
- Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in CombinationStatus unknownPhase 2PD Dr. Andrew ChanNCT01627938Written as Dexrazoxane (DRZ) plus Mitoxantrone (MX)
- Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone SarcomaTerminatedPhase 2City of Hope Medical CenterNCT00544778Written as dexrazoxane hydrochloride
- Combination Chemotherapy With or Without Dexrazoxane in Treating Children With Hodgkin's DiseaseCompletedPhase 3Children's Oncology GroupNCT00005578Written as dexrazoxane hydrochloride
- Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or LeukemiaTerminatedPhase 1National Cancer Institute (NCI)NCT00933985Written as dexrazoxane hydrochloride
See all 25 studies that test Dexrazoxane →
Given in every arm · 23 — Dexrazoxane is usual care beside what is tested
- A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 MutationsRecruitingPhase 3Children's Oncology GroupNCT04293562Written as Dexrazoxane Hydrochloride
- Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)RecruitingPhase 3Children's Oncology GroupNCT03126916Written as Dexrazoxane Hydrochloride
- Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary BlastomaRecruitingPhase 3Children's Oncology GroupNCT06647953Written as Dexrazoxane
- Venetoclax Basket Trial for High Risk Hematologic MalignanciesRecruitingPhase 1Andrew E. Place, MDNCT05292664Written as Dexrazoxane
- CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML PatientsRecruitingPhase 2Princess Maxima Center for Pediatric OncologyNCT06262438Written as Dexrazoxane
- Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic LeukemiaActive, not recruitingPhase 3Children's Oncology GroupNCT03007147Written as Dexrazoxane Hydrochloride
- 05-001: Treatment of Acute Lymphoblastic Leukemia in ChildrenCompletedPhase 3Dana-Farber Cancer InstituteNCT00400946Written as dexrazoxane hydrochloride
- Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk NeuroblastomaCompletedPhase 2National Cancer Institute (NCI)NCT03786783Written as Dexrazoxane
- Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk RhabdomyosarcomaActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT00077285Written as dexrazoxane hydrochloride
- A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid LeukemiaActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT03164057Written as Dexrazoxane
- Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing SarcomaActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT01864109Written as Dexrazoxane
- Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing SarcomaCompletedPhase 3Children's Oncology GroupNCT01231906Written as Dexrazoxane
- Study of DPPG2-TSL-DOX Combined With Hyperthermia in Soft Tissue SarcomaCompletedPhase 1Thermosome GmbHNCT05858710Written as Dexrazoxane
- Crizotinib and Combination Chemotherapy in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell LymphomaCompletedPhase 1Children's Oncology GroupNCT01606878Written as Dexrazoxane Hydrochloride
- Vincristine, Doxorubicin, Cyclophosphamide and Dexrazoxane (VACdxr) in High Risk Ewing's Sarcoma PatientsTerminatedPhase 2M.D. Anderson Cancer CenterNCT00038142Written as Dexrazoxane
- Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)TerminatedPhase 1Therapeutic Advances in Childhood Leukemia ConsortiumNCT00928200Written as Dexrazoxane
- Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)CompletedPhase 1/2Children's Oncology GroupNCT00098839Written as dexrazoxane hydrochloride
- Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient ChemotherapyTerminatedNot applicableM.D. Anderson Cancer CenterNCT00673179Written as Dexrazoxane
- Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic OsteosarcomaCompletedPhase 3Children's Oncology GroupNCT00003937Written as dexrazoxane hydrochloride
- Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic OsteosarcomaCompletedPhase 1Children's Oncology GroupNCT00742924Written as dexrazoxane hydrochloride
Showing 20 of 23.
As the comparator · 3 — what is tested is compared with Dexrazoxane
- Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and AdolescentsActive, not recruitingPhase 3Dana-Farber Cancer InstituteNCT03020030Written as Dexrazoxane
- Marched Pair Study Conventional Doxorubicin(DOX) Versus Pegylated Liposomal Doxorubicin(PLD) Neoadjuvant ChemotherapyStatus unknownPhase 2Jilin UniversityNCT02953184Written as Dexrazoxane (DZR)
- Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's LymphomaCompletedPhase 3Children's Oncology GroupNCT01230983Written as dexrazoxane hydrochloride
Codes
What other systems call Dexrazoxane · ClinicalTrials.gg INT008975
- MeSH (NLM) D064730DexrazoxaneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 048L81261FDEXRAZOXANEConfirmed FDA, NLM, Wikidata
- RxNorm 42736Confirmed FDA, Wikidata
- Wikidata Q524995dexrazoxaneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1333DexrazoxaneOne source FDA
- DrugBank DB00380One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D064730 | Dexrazoxane | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 048L81261F | DEXRAZOXANE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 42736 | — | Confirmed FDA, Wikidata |
| Wikidata | Q524995 | dexrazoxane | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1333 | Dexrazoxane | One source FDA |
| DrugBank | DB00380 | — | One source Wikidata |
Also registered as dexrazoxane hydrochloride (UNII 5346058Q7S · RxNorm 1294534).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.