Sleepiness clinical trials
The registry lists 92 studies for Sleepiness across more than 10 countries. 20 are recruiting or about to start. 19 of them are mainly about Sleepiness (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University Hospital, Bordeaux (5) · University Hospital, Montpellier (3) · Brigham and Women's Hospital (3) · VA Office of Research and Development (3) · Hospices Civils de Lyon (2) · Stanford University (2) · Assistance Publique - Hôpitaux de Paris (2) · Celgene (2)
What is being tested here
Drugs under test in Sleepiness studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Modafinil | 0 | 2 | 4 |
| Pitolisant | 0 | 1 | 1 |
| Cytotoxic Agent-LAT1 Substrate QBS10072S | 0 | 0 | 1 |
| Minocycline | 0 | 0 | 1 |
| Paroxetine | 0 | 0 | 1 |
| Montelukast | 0 | 0 | 1 |
| Lorazepam | 0 | 0 | 1 |
| Aprepitant | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Jun 2027A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304) · Phase 3 · Alkermes, Inc.
- Sep 2027A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence · Phase 3 · Centessa Pharmaceuticals (UK) Limited
- Dec 2026Objective Assessment of the Effects of Shift Work on Drowsiness and Driving Impairment in Hospital Staff · Brigham and Women's Hospital
- Dec 2026Predicting Declines in Attention and Memory During a Prolonged Mental Task · DSW Ideis University
- Dec 2026Sleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia Nurses · Volkan Gokmen
- Dec 2026Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression · Jakub Antczak
- Dec 2026Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD · VA Office of Research and Development
- Dec 2026Predictors of Post-COVID-19 Clinical and Cognitive Consequences · VA Office of Research and Development
- Apr 2027Homeostatic Regulation of Sleep in Short Sleepers · University Hospital, Montpellier
- Sep 2027Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome) · VA Office of Research and Development
Who these studies take
Of the 10 Sleepiness studies recruiting now, 4 (40%) set no upper age limit and 5 (50%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 8 (80%) | 8 (80%) |
| 30 | 8 (80%) | 8 (80%) |
| 40 | 8 (80%) | 8 (80%) |
| 50 | 8 (80%) | 8 (80%) |
| 65 | 10 (100%) | 10 (100%) |
| 75 | 6 (60%) | 6 (60%) |
| 85 | 5 (50%) | 5 (50%) |
Across all 92 studies, recruiting or not: 49% stop at 75 or younger and 40% at 65; 13% take children; 5% are for women only and 7% for men only; 54% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sleepiness studies take
Of 22 interventional studies with no phase under Sleepiness, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo6–32 · 22 studies | — | — |
| Observational | 22 mo11–39 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Predicting Declines in Attention and Memory During a Prolonged Mental TaskOct 16, 2026NCT07877389
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of HypersomnolenceRecruitingNCT07598708Phase 2/31 country
- Predicting Declines in Attention and Memory During a Prolonged Mental TaskNot yet recruitingNCT07877389Not applicable1 country
- A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)RecruitingNCT07540897Phase 35 countries
- Sleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia NursesNot yet recruitingNCT078327211 country
- Hypersomnia in the Paediatric PopulationNot yet recruitingNCT07766343Not applicable1 country
- Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)RecruitingNCT04179981Not applicable1 country
- TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTSEnrolling by invitationNCT07434921Not applicable1 country
- Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPDRecruitingNCT02703207Not applicable1 country
- Homeostatic Regulation of Sleep in Short SleepersNot yet recruitingNCT07584538Not applicable1 country
- Predictors of Post-COVID-19 Clinical and Cognitive ConsequencesRecruitingNCT062918701 country
- Obstructive Sleep Apnea Therapeutic Intervention for REsiDual SleepinessRecruitingNCT06698809Not applicable1 country
- Study of Circadian Focused Light Therapy in Progressive Multiple SclerosisEnrolling by invitationNCT06261528Phase 11 country
- Impact of Atrial Fibrillation Ablation on Sleep Parameters.RecruitingNCT072592001 country
- Shift Hours' Impact on Fatigue and Tracking of Eye DynamicsNot yet recruitingNCT07192380Not applicable1 country
- Effect of Different Foot Baths on Postpartum Insomnia and FatigueNot yet recruitingNCT07060755Not applicable
- VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agentsNot yet recruitingNCT07064382Not applicable
- Assessment of Tiredness During Awake Resection of Intracerebral TumorsRecruitingNCT069224871 country
- Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in DepressionRecruitingNCT06371352Not applicable1 country
- Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)Not yet recruitingNCT06027047
- Ocular Parameters in Patients With Sleep ApneaRecruitingNCT059117371 country
- Improving Outcomes for Patients With SDB and Insufficient SleepCompletedNCT04279834Not applicable1 country
- A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic HypersomniaCompletedNCT05156047Phase 31 country
- Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With HypersomnolenceCompletedNCT05615584Not applicable1 country
- Study of Psychological, Sociological and Professional Factors Associated With Maintenance of Wakefulness TestCompletedNCT065861381 country
- Perceived Barriers and Facilitators to Physical Activity in Turkish YouthCompletedNCT073201311 country
- Lifestyle Coaching for Fatigue Mitigation in Emergency Medicine ResidentsWithdrawnNCT06015646Not applicable1 country
- Chronic Non-inflammatory Pains in RheumatopediatricsWithdrawnNCT037403471 country
- Exploring Biological Markers of Driver Fatigue for Enhanced Road SafetyCompletedNCT070893421 country
- A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic HypersomniaCompletedNCT05458128Phase 31 country
- Effect of Lavender on Sleep Quality and Insomnia Severity in PatientsCompletedNCT06778876Not applicable1 country
- Transdisciplinary Intervention for Obesity Hypoventilation SyndromeCompletedNCT070206891 country
- Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)CompletedNCT030985891 country
- Neural Interfaces to Monitor Fatigue and Sleepiness in the CathlabCompletedNCT050412181 country
- Investigate Effects of A2 Milk on Breastmilk Composition and Subsequent Infant Gut Health, Crying and Sleep Patterns in Healthy, Full-term InfantsCompletedNCT05829720Not applicable1 country
- Voice Biomarkers to Predict Excessive Daytime SleepinessCompletedNCT04942574Not applicable1 country
- Objective Assessment of the Effects of Shift Work on Drowsiness and Driving Impairment in Hospital StaffActive, not recruitingNCT016724891 country
- A Study of Plant-based Diet on Postprandial SleepinessCompletedNCT05706649Not applicable1 country
- Integral Physiological Adaptations to Carbohydrate PeriodizationCompletedNCT05464342Not applicable2 countries
- Metabolomics-based Sleepiness MarkersCompletedNCT05585515Not applicable1 country
- Simulated Dawn Med StudentsCompletedNCT02088593Not applicable1 country
- Light Therapy Treatment in Parkinson's Disease Patients With Daytime SomnolenceCompletedNCT01338649Not applicable1 country
- Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072SCompletedNCT04430842Phase 11 country
- Effects of Chronobiology-guided Lifestyle Interventions on Insomnia Severity, Cognitive Performance, and SleepinessStatus unknownNCT05569603Not applicable1 country
- A Safety and Efficacy of Pomalyst® Capsules Under the Actual Use in All Patients Who Are Treated With Pomalyst at a Dose of 1 mg, 2 mg, 3 mg, or 4 mgCompletedNCT029218282 countries
- Sleep Time and Insomnia Factors Among Professional Flight MembersStatus unknownNCT047617961 country
- Performance Nutrition for Residents and FellowsCompletedNCT03698123Not applicable1 country
- Obstructive Sleep Apnoea in SarcoidosisCompletedNCT041567891 country
- Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway MicrobiomeStatus unknownNCT05116657
- The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel SyndromeCompletedNCT050473671 country
- Sleepiness in Parkinson's Patients With Continuous Dopaminergic Delivery Device or Deep Brain StimulationStatus unknownNCT044416971 country