Voice Biomarkers to Predict Excessive Daytime Sleepiness

• Male ou female volunteers, who are between 18 and 50 years old,
• With a BMI (Body Mass Index) between 18.5 and 25 kg/m2 for volunteers who are between 18 and 34 years old, or a BMI between 18.5 and 27 kg/m2 for volunteers who are between 35 and 50 years old ,
• Not having subjective EDS (Excessive Daytime Sleepiness) : total score at ESS (Epworth Sleepiness Scale) lower or equal to 11,
• Not having insomnia complaints (ISI total score lower than 8),
• Having a SCL90R (Symptom Check List- 90 items Revised) score lower than 60 (only for Anxiety and Depression categories' items of the checklist),
• Regular bedtime between 22H00 and 0H00, regular get up time between 6H00 and 8H00,
• Daily TST (Total Sleep Time) between 7 and 9 hours,
• With no strong suspicion of OSAS (Obstructive Sleep Apnea Syndrome) as assessed by STOP-BANG questionnaire,
• With no suspicion of RLS (Restless Legs Syndrome) as assessed by RLS screening questionnaire,
• With sufficient reading abilities for the reading task as assessed by ECLA16+ ("Evaluation des Compétences de Lecture chez l'Adulte de plus de 16 ans" :

higher ou equal performances than 25th percentile for performances assessed in total population for the following tasks : " lecture de " l'Alouette " " (Number of correctly read words / minute ≥ 121, number of errors ≤ 10), isolated words reading (regular words : score ≥ 18, time ≤ 17 sec ; irregular words : score ≥ 16, time ≤ 16 sec, pseudo-words : score ≥ 17, time ≤ 26 sec), repetition of non-words (score ≥ 19), and symbol crossing task (number of crossed symbols ≥ 22),

• With a SE (Sleep Efficiency) higher or equal to 85% as assessed by the 7 nights-actigraphy made before inclusion,
• With an AHI (Apnea/Hypopnea Index) lower or equal to 10 apnea or hypopnea/hour of sleep as assessed by the ventilatory polygraphy,
• With a PLMI (Periodic Limb Movement Index) lower or equal to 15 sequences of PLM/hour of sleep as assessed by the ventilatory polygraphy,
• Being an affiliated member of the Social Security system,
• Being able to understand the study,
• Being available to come at the four visits necessary for the study,
• Having given written informed consent to participate to the study.

Exclusion Criteria:

• Having a life-threatening disease,
• Any evolutive cardiovascular pathology - under treatment or not,
• Any evolutive neurologic pathology - under treatment or not (brain tumour, epilepsy, headache, stroke, sclerosis, myoclonia, chorea, neuropathy, muscular dystrophies, myotonic dystrophy),
• Psychiatric disorders - under treatment or not (characterised depressive episode, bipolar disorders, psychotic disorders, neurodevelopmental diseases),
• Untreated endocrine disorders (diabetes, hyperthyroidism),
• Dependency to a substance,
• otorhinolaryngological disorder that could induce vocal parameters modification,
• Fluence disorders (cluttering, stuttering), language disorders (dyslexia) or visual troubles that could impact reading abilities,
• Participant under psychotropic treatment (antidepressants, antihistamine, etc...), or under treatment that could interfere with sleep or wakefulness level,
• Participant under treatment that could impact the normal muscular function (myorelaxant, neuromuscular blocking agents injections in maxillofacial area, etc...),
• Dental care during the follow-up of the study,
• Shift-worker or night-worker,
• Excessive consumption of alcohol (>2 glasses per day) during the 6 last months,
• Excessive consumption of coffee, tea, or any drink containing caffeine (like cola) (> 5 cups/day),
• Excessive tobacco smoking (>5 cigarets/day),
• Non-native French speaker,
• Participant with a thick accent that could induce significantly vocal parameters modification (at the discretion of the investigator),
• Deprived of liberty by a legal or administrative procedure,
• Under tutorship or guardianship,
• Pregnant or breastfeeding woman.