An observational study in Juvenile Idiopathic Arthritis, sponsored by Assistance Publique - Hôpitaux de Paris. Withdrawn at 1 site in France. Open to participants aged 12 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-04-03.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
The purpose of this study is to determine the frequency of chronic pain in adolescent with juvenile idiopathic arthritis, especially when the disease is inactive or with minimal activity.
Secondary objectives are, first to determine intensity of pain and its repercussion in daily life and second to determine risk factor of chronic pain.
Juvenile idiopathic arthritis is the most frequent pathology in paediatric rheumatology clinic. Pain is an important symptom in paediatric rheumatology. It is actually poorly studied and is not evaluate in disease activity score like the Juvenile Arthritis Disease Activity Score (JADAS). It is source of handicap, social and psychological distress and greatly contribute to poor quality of life. Chronic pain is frequently multifactorial, even in inflammatory disease. In adult population, rheumatologists have shown an association between inflammatory disease like spondylarthritis or rheumatology polyarthritis and fibromyalgia.
There is no specific data on chronic pain in juvenile idiopathic arthritis. Pain is mostly evaluated by the Visual Analogue Scale (VAS) with no evaluation of pain repercussion on daily life or its chronicity. This study's primary objective is to determine the frequency of chronic pain and its relationship with disease activity. Secondaries objectives are to determine repercussion of pain in daily life, and risk factor of chronic pain.
To responded to this objective, we will conduct a transversal study in a paediatric rheumatology refence centre in Necker-Enfants malades Hospital. We will include all patients between 12 and 18 years old followed in our centre for any type of juvenile idiopathic arthritis.
Patients will be evaluated as usual by their paediatrics rheumatologist during a follow-up consultation or hospitalisation with the used of the clinical JADAS. Patient accepting to participate the study will be given a paper questionnaire evaluating chronic pain, its repercussion, anxiety (by the used of the Revised Children's Manifest Anxiety Scale (RCMAS score)), depression (by the used of the Children's Depression Inventory (CDI score)), Sleepiness (by the used of the Pediatric Daytime Sleepiness Scale (PDSS score)) and quality of life (by the used of the measurement model for the Pediatric Quality of Life inventory (PedQL score)).
365 studies on the registry are indexed under Arthritis, Juvenile; 101 are open to participants now.
Browse Arthritis, Juvenile studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,592 studies on the registry; 1,033 are open to participants now.
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Patients over 12 years of age followed for juvenile idiopathic arthritis in the reference center at Necker-Enfants malades Hospital (RAISE)
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Exclusion Criteria:
No exclusion criteria
Patients followed for juvenile idiopathic arthritis and chronic pain in Necker Hospital
Behavioral: Questionnaires
Response to questionnaires evaluating chronic pain and its repercussion : * anxiety questionnaire (Revised Children's Manifest Anxiety Scale), * depression questionnaire (Children's Depression Inventory score), * sleepiness questionnaire (Pediatric Daytime Sleepiness Scale), * quality of life questionnaire (Pediatric Quality of Life inventory score).
Also known as: Evaluation of the chronic pain repercussion in juvenile idiopathic arthritis
Frequency of chronic pain and its relationship with disease activity
Chronic pain will be defined by the presence of recurrent or permanent moderate pain (Visual Analogue Scale (VAS) \> 3 / 10), present more than 3 days a week. Disease activity will be evaluated by the clinical Juvenile Arthritis Disease Activity Score (JADAS) and the definition of three groups: inactive disease, minimal disease activity and active disease.
Time frame: Day 0
Chronic pain and disease repercussions
Chronic pain and disease repercussion will be assessed by a paper questionnaire evaluation repercussion on scholarship, sports, sleep and social interaction.
Time frame: Day 0
Repercussions of pain on patient anxiety
Anxiety symptoms will be assessed with the Revised Children's Manifest Anxiety Scale (RCMAS) questionnaire
Time frame: Day 0
Repercussions of pain on depression symptoms
Depression symptoms will be assessed with the Children's Depression Inventory (CDI) questionnaire
Time frame: Day 0
Repercussions of pain on quality of life
Anxiety symptoms will be assessed with the Pediatric Quality of Life inventory (PedQL) questionnaire
Time frame: Day 0
Repercussions of pain on patient daytime sleepiness
Anxiety symptoms will be assessed with the Pediatric Daytime Sleepiness Scale (PDSS score)
Time frame: Day 0
Plan to share: No
Ran from Nov 2018 to primary completion in Nov 2018, 0 months.
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This study is withdrawn, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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