An interventional study of Total sleep deprivation and Partial sleep deprivation in Sleep Deprivation, sponsored by Örebro University, Sweden. Not yet recruiting at 1 site in Sweden. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by Örebro University, Sweden · Not applicable, Interventional, and Basic science
This study aims to examine how total and partial sleep deprivation affect brain function, cognitive performance, and biomarkers related to stress and inflammation in the same participants using a crossover design. The study will also compare the effects of total and partial sleep deprivation to determine whether these conditions affect the brain and body differently. The findings may improve our understanding of the consequences of sleep deprivation and help inform strategies to reduce its negative impact on health and society.
Participants will complete three study conditions in a randomized order:
Total Sleep Deprivation (TSD): 28 to 32 hours of continuous wakefulness. Partial Sleep Deprivation (PSD): sleep restricted to 4 hours per night for two consecutive nights.
Normal Sleep (control condition): a night of habitual sleep without sleep restriction.
314 studies on the registry are indexed under Sleep Deprivation; 59 are open to participants now.
This study's planned enrollment of 24 is below the median of 50 across 259 interventional studies indexed under Sleep Deprivation.
Browse Sleep Deprivation studies →Örebro University, Sweden is the lead sponsor of 86 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: Normal sleep
Behavioral: Total sleep deprivation
Behavioral: Partial sleep deprivation
No sleep for 28-32 hours.
Restriction to 4 hours sleep/night for two consecutive nights.
Normal (7-9 hours) sleep, following normal patterns of wakeup and sleep onset.
Brain functional activity and connectivity (PVT)
Compare normal sleep to SD (total and partial)
Time frame: 3 weeks
Brain functional activity and connectivity (PVT) - SD
Compare total sleep deprivation and partial sleep deprivation.
Time frame: 3 weeks
Brain functional activity and connectivity (NBACK)
Time frame: 3 weeks
Brain functional activity and connectivity (MST)
Time frame: 3 weeks
Brain functional activity and connectivity (SST)
Time frame: 3 weeks
Brain functional activity and connectivity (EMOREG)
Time frame: 3 weeks
Resting state fMRI
Total SD vs Partial SD
Time frame: 3 weeks
Structural MRI
Total SD vs. Partial SD
Time frame: 3 weeks
Diffusion tensor imaging
Total SD vs Partial SD
Time frame: 3 weeks
Cognitive function (NBACK)
Time frame: 3 weeks
Cognitive function (MST)
Time frame: 3 weeks
Cognitive function (SST)
Time frame: 3 weeks
Cognitive function (EMOREG)
Time frame: 3 weeks
Levels of inflammatory markers (e.g. high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha)
Time frame: 3 weeks
Levels of neural function markers (e.g. brain derived neurotrophic factor (BDNF)
Time frame: 3 weeks
Salivary biomarkers (e.g., melatonin and cortisol)
Time frame: 3 weeks
Electrophysiological measures (e.g., ECG)
Time frame: 3 weeks
Assessment of psychological health using Hospital Anxiety and Depression Scale (HADS)
Time frame: 3 weeks
Assessment of psychological health using Pittsburgh Sleep Quality Index (PSQI)
Time frame: 3 weeks
Assessment of psychological health using Perceived Stress Scale (PSS)
Time frame: 3 weeks
Assessment of subjective sleepiness using the Karolinska Sleepiness Scale (KSS)
Time frame: 3 weeks
Assessment of sleep quality and sleep disturbances using the Karolinska Sleep Questionnaire (KSQ)
Time frame: 3 weeks
Assessment of daytime sleepiness using the Epworth Sleepiness Scale (ESS)
Time frame: 3 weeks
Assessment of chronotype (morningness-eveningness preference) using the Reduced Morningness-Eveningness Questionnaire (rMEQ)
Time frame: 1
Assessment of sleep-related positive and negative affect using the Negative and Positive Affect Scale for Sleep (NAP-AS)
Time frame: 3 weeks
Faecal samples for evaluation of gut microbiota composition
Time frame: 1 day
Levels of neural function markers (e.g. S100B)
Time frame: 3 weeks
Physical activity assessed using actigraphy
Time frame: 3 weeks
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Sep 2026; primary completion for Jun 2027, 9 months later.
Of 141 non-industry interventional studies with no phase under Sleep Deprivation, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 44. This study's planned 9 months is below that.
Counting every sponsor, half of 150 studies reached it within 17 months; a quarter within 7 and three quarters within 37.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Örebro University, Sweden