Pulmonary Edema clinical trials
The registry lists 126 studies for Pulmonary Edema across more than 10 countries. 27 are recruiting or about to start. 61 of them are mainly about Pulmonary Edema (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Who runs them
Assistance Publique - Hôpitaux de Paris (4) · Dalarna County Council, Sweden (4) · Assiut University (4) · Mayo Clinic (3) · GlaxoSmithKline (3) · University Hospital, Strasbourg, France (2) · Ospedale S. Giovanni Bosco (2) · Duke University (2)
What is being tested here
Drugs under test in Pulmonary Edema studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Oxygen | 1 | 1 | 2 |
| Nitroglycerin | 1 | 1 | 1 |
| Furosemide | 1 | 0 | 1 |
| Isosorbide Dinitrate | 1 | 0 | 1 |
| Sildenafil | 0 | 0 | 2 |
| Imatinib | 0 | 0 | 2 |
| Norepinephrine | 0 | 1 | 1 |
| Milrinone | 0 | 0 | 1 |
| Dobutamine | 0 | 0 | 1 |
| Magnesium Sulfate | 0 | 1 | 1 |
Drug classes tested here PDE5 inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU · Brigham and Women's Hospital
- Nov 2026Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases · Assiut University
- Apr 2027Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Apr 2027Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials · Centre Hospitalier Régional d'Orléans
- May 2027DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure · Copenhagen University Hospital, Rigshospitalet
- Jul 2027PEP-device for Treatment of Swimming-induced Pulmonary Edema (SIPE) · Dalarna County Council, Sweden
- Jul 2027O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS) · Dalarna County Council, Sweden
Who these studies take
Of the 20 Pulmonary Edema studies recruiting now, 18 (90%) set no upper age limit and 1 (5%) stop at 75 or younger. 2 (10%) take children under 18. 3 (15%) are for women only and 0 (0%) for men only; 5 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (10%) | 0 (0%) |
| 18 | 18 (90%) | 15 (75%) |
| 30 | 18 (90%) | 15 (75%) |
| 40 | 18 (90%) | 15 (75%) |
| 50 | 18 (90%) | 15 (75%) |
| 65 | 18 (90%) | 15 (75%) |
| 75 | 18 (90%) | 15 (75%) |
| 85 | 19 (95%) | 16 (80%) |
Across all 126 studies, recruiting or not: 13% stop at 75 or younger and 12% at 65; 7% take children; 10% are for women only and 0% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pulmonary Edema studies take
Of 27 observational studies under Pulmonary Edema, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 39 mo12–69 · 22 studies | — | — |
| Observational | 28 mo7–57 · 27 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Predictive Role of Lung Ultrasound in Re-Expansion Pulmonary Edema During ThoracocentesisOct 15, 2026NCT07875764
Studies
Recruiting first, then most recently updated. Showing 50 of 126. Browse all 126 → or search them.
- Detecting Early Weaning-induced Pulmonary Oedema Using Lung Impedance Negative Trend During Spontaneous Breathing TrialsNot yet recruitingNCT078866711 country
- DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart FailureRecruitingNCT05276219Phase 41 country
- PEP-device for Treatment of Swimming-induced Pulmonary Edema (SIPE)RecruitingNCT05227222Not applicable1 country
- Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)RecruitingNCT053917371 country
- O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS)RecruitingNCT04307615Not applicable1 country
- Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary DiseasesRecruitingNCT069833661 country
- Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna TrialRecruitingNCT06686251Not applicable1 country
- Multimodal Physiologic State Intelligence StudyEnrolling by invitationNCT078141181 country
- Evaluating the Use of Prehospital Lung Ultrasound in EMS: A Multicenter Pilot StudyNot yet recruitingNCT07549334Not applicable1 country
- Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary OedemaNot yet recruitingNCT07666880Not applicable1 country
- Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)RecruitingNCT05226247Not applicable1 country
- Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing TrialsRecruitingNCT06923267Not applicable1 country
- MRI Assessment of Pulmonary Edema in Acute Heart FailureRecruitingNCT039991381 country
- Heparin-binding Protein and Lungedema in ICU Patients.RecruitingNCT074349081 country
- Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical VentilationNot yet recruitingNCT07343882Not applicable
- Lung Ultrasound for the Detection of Volume Overload in Patients With Severe PreeclampsiaRecruitingNCT07261956Not applicable1 country
- Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICURecruitingNCT06538376Not applicable1 country
- Ultrasound Investigation Into Swimming Induced Pulmonary Edema in Open Water Swimming AthletesRecruitingNCT063848851 country
- Comparison of Respiratory Support for Acute Pulmonary EdemaNot yet recruitingNCT06820112
- Different Regimens of Magnesium Sulphate in Patients with Severe PreeclampsiaRecruitingNCT067916681 country
- Pulmonary Edema Resolution in Severe Preeclampsia and EclampsiaRecruitingNCT062191091 country
- High Versus Low Dose Nitroglycerin in Acute Pulmonary EdemaEnrolling by invitationNCT06107465Phase 2/31 country
- Cardiogenic Acute Pulmonary Edema in Subjects Over 75 Years Old: Impact of Non-invasive Ventilation on MortalityRecruitingNCT061072571 country
- Ultrasound in Evaluation of Preoperative Fluid Management of Hip Fracture Surgery PatientsRecruitingNCT059165991 country
- Prevalence of Venous conGestion and Its Association With Renal Injuries Evaluated by the VExUS Score On Admission With UltraSound in Patients With Cardiogenic Pulmonary EdemaRecruitingNCT058816031 country
- Screening for Individual Susceptibility Factors to Immersion Pulmonary EdemaRecruitingNCT05049889Not applicable1 country
- Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk PatientsRecruitingNCT049735791 country
- Treatment of ARDS With Instilled T3CompletedNCT04115514Phase 21 country
- Chest U/S in Differentiating Lung Congestion & Pneumonia in Adult Critically-ill Patients and Its Prognostic ImpactCompletedNCT056366311 country
- Oxygen Targets in Acute Heart Failure With Pulmonary CongestionCompletedNCT05613218Phase 2/31 country
- Predictive Role of Lung Ultrasound in Re-Expansion Pulmonary Edema During ThoracocentesisCompletedNCT07875764Not applicable1 country
- Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized PatientsActive, not recruitingNCT076564281 country
- CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary EdemaCompletedNCT00213681Phase 31 country
- Increased Extravascular Lung Water in Asymptomatic Open-water SwimmersCompletedNCT069841201 country
- Prediction Of Pulmonary Edema With Müller ManeuverWithdrawnNCT05358405Not applicable1 country
- A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney InjuryActive, not recruitingNCT055383511 country
- Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress SyndromeCompletedNCT062503481 country
- Helmet CPAP vs Facemask CPAP in ACPE (hCPAP vs fCPAP)CompletedNCT04014088Not applicable
- GRAvity- Versus Wall Suction-drIven Large Volume Thoracentesis: a RAndomized Controlled Study (GRAWITAS Study)CompletedNCT05131945Not applicable1 country
- Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot TrialTerminatedNCT03259165Phase 21 country
- The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic ShockCompletedNCT06461390Phase 2/31 country
- B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot TrialCompletedNCT03136198Phase 21 country
- Screening of Postoperative Pulmonary Complications by Electrical Impedance TomographyCompletedNCT023376731 country
- Retrospective Study of Carebot AI CXR Performance in Preclinical PracticeCompletedNCT055944851 country
- Predictive Value of Chest Ultrasound Observation on Extubation FailureStatus unknownNCT059445881 country
- Lung Ultrasound Patterns PreeclampsiaCompletedNCT03576092
- Mechanically Optimizing Cardiac Preload in Heart Failure PatientsStatus unknownNCT043385031 country
- Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical VentilationCompletedNCT047033871 country
- Intravenous Imatinib in Mechanically Ventilated COVID-19 PatientsTerminatedNCT04794088Phase 21 country
- Thoracic Fluid Content by Bioimpedance-based Starling SystemCompletedNCT056767231 country