An interventional study of Spontaneous breathing trial in Mechanical Ventilation Complication and Pulmonary Edema, sponsored by Centre Hospitalier Universitaire de Nice. Recruiting at 3 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-22.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Diagnostic
Among 22 studies in Pulmonary Edema with a site in France — 6 open to participants now, 6 under way, none of them phase 3. Pulmonary Edema · France.
Among the 22 studies in Pulmonary Edema with a site in France, this one is the 2nd largest by planned enrollment of the 12 interventional ones, is one of 4 that started in 2022, is one of 10 with no phase, and was the 13th registered.
126 studies on the registry are indexed under Pulmonary Edema; 27 are open to participants now.
This study's planned enrollment of 250 is above the median of 65 across 62 interventional studies indexed under Pulmonary Edema.
Browse Pulmonary Edema studies →6 of the 22 studies in Pulmonary Edema with a site in France are open now, in 1 country. Each count lists the studies.
Of the 20 Pulmonary Edema studies recruiting now, 18 (90%) set no upper age limit and 1 (5%) stop at 75 or younger; 2 take children under 18; 5 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →22 studies; the count open now beside each. This study's row is marked.
First in 2002; this study’s year is marked. 4 started in 2022.
Median enrollment 79 across the 12 interventional studies, 100 across the 8 observational. Of the 10 that completed or were terminated, 0 (0%) have results posted.
None of the 22 has an industry lead sponsor. The 10 most frequent:
Centre Hospitalier Universitaire de Nice is the lead sponsor of 723 studies on the registry; 176 are open to participants now.
Centre Hospitalier Universitaire de Nice has 1 study filed under Pulmonary Edema — fewer than ten, so there is no comparison to draw.
1 of the studies in Pulmonary Edema with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06923267Centre Hospitalier Régional d'OrléansUltrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials | 2027-04-09 |
Among the 22 studies in Pulmonary Edema with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
Weaning from mechanical ventilation remains a central step in the management of critically-ill patients, since weaning failure and prolonged duration of mechanical ventilation are not only associated with an increase in the length of stay in intensive care but also with greater morbidity and mortality. One of the well-recognized causes of weaning failure is weaning-induced pulmonary edema (WIPO), which accounts for almost 60% of the causes of weaning failure and ranging up to 75% in high-risk patients, i.e. patients with medical history of chronic heart disease, chronic respiratory failure and obesity.
Echocardiography is increasingly used in intensive care and allows non-invasive assessment of diastolic function as well as left ventricular (LV) and right (RV) systolic function, including during a spontaneous breathing test. Although LV diastolic dysfunction appears to be a major determinant of WIPO, the role of LV and RV systolic dysfunction is less unequivocal and has been poorly studied so far. Scarce data showed that patients experiencing WIPO tended to exhibit more frequently LV systolic dysfunction, as demonstrated by a lower LV ejection fraction (LVEF) and no study but two have investigated the potential role of RV systolic function. Moreover, assessing LV systolic function with LVEF measurement suffers from several limitations, especially in critically-ill patients.
Thus, the main goal of this study is to investigate whether LV and RV systolic function is involved in the development of WIPO. The second goal of this study is to determine the best echocardiographic parameter to assess LV and RV systolic function during the weaning process.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:
Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Critically-ill patients under mechanical ventilation for more than 48h, who are at high-risk of weaning-induced pulmonary edema and in whom the attending physician decided to perform a spontaneous breathing trial.
Procedure: Spontaneous breathing trial
To perform cardiac and lung echography before and during a spontaneous breathing trial
Proportion of patients experiencing left and/or right ventricular
Left ventricular systolic function will be assessed by several
Time frame: 24 months
Proportion of patients experiencing a weaning-induced pulmonary
WiPO is defined by new acute respiratory failure during spontaneous
Time frame: 24 months
Clinical and echocardiographic predictors of weaning-induced
To test the ability of different clinical and echocardiographic
Time frame: 24 months
Plan to share: No — No plan is established
No publications or documents are linked to this record.
Started Aug 2022 (actual). Primary completion is estimated for Aug 2026, 48 months after the start.
Of 22 interventional studies with no phase under Pulmonary Edema, half reached primary completion within 39 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 69. This study's planned 48 months is above that.
How these figures are worked out, and which studies are left out of them.
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Centre Hospitalier Universitaire de Nice →