An observational study in Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning and Spontaneous Breathing Trial, sponsored by Unity Health Toronto. Not yet recruiting at 1 site in Canada. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by Unity Health Toronto · Observational
Critically ill patients who require a breathing machine are routinely assessed with a spontaneous breathing trial (SBT) to determine if they can safely breathe on their own. If the trial fails, the breathing machine must be continued. One common cause is weaning-induced pulmonary oedema (WIPO), in which the heart cannot handle the increased workload during spontaneous breathing, causing fluid to accumulate in the lungs. Although several markers can suggest WIPO, it is often diagnosed after the SBT has already failed. Earlier recognition could allow clinicians to treat the condition promptly, improving the success rate of subsequent trials.
This study will examine whether electrical impedance tomography (EIT)-a bedside monitor that tracks how air moves in the lungs-can help identify WIPO earlier. We will focus on how lung aeration changes in the first minutes of the trial and whether combining EIT with standard clinical measurements improves early prediction of SBT outcome and identification of WIPO.
Study procedures will take place during routine SBTs and are mostly non-invasive. Participants will undergo EIT monitoring, heart and lung ultrasound, ventilator measurements, and blood tests. Clinical care remains entirely according to the ICU team. Participants will be followed for up to 28 days.
Unity Health Toronto is the lead sponsor of 444 studies on the registry; 80 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 1 (20%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients who are at higher risk of developing weaning-induced pulmonary edema who are in participating intensive care units (ICU): Medical-Surgical ICU, Trauma-Neuro ICU, and Cardiac ICU
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Patients at increased risk for WIPO, defined as meeting either of the following:
Exclusion Criteria:
Monitoring during a spontaneous breathing trial
Changes in end-expiratory lung impedance
A marker derived from electrical impedance tomography that reflects changes in lung volume associated with different treatments; in this case, the change from clinical settings of mechanical ventilation to the spontaneous breathing trial (SBT) settings.
Time frame: The entire duration of SBT; routinely planned for 30-120 minutes
Left atrial strain index
Echocardiography-derived parameter that quantifies the wall strain of the left atrium, reflecting the dynamic changes in volume and pressure status.
Time frame: The entire duration of SBT; routinely planned for 30-120 minutes
Plan to share: No — The datasets generated and/or analyzed during the current study are not publicly available due participant confidentiality, according to the REB, but are available from the corresponding author on reasonable request.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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