An interventional study of Lung ultrasound in Pulmonary Edema - Acute and Preeclampsia, sponsored by Saint Thomas Hospital, Panama. Recruiting at 1 site in Panama. Open to female participants. Per ClinicalTrials.gov, last updated 2025-12-03.
Sponsored by Saint Thomas Hospital, Panama · Not applicable, Interventional, and Diagnostic
This research aims to evaluate the usefulness of lung ultrasound (LUS) for detecting and monitoring fluid overload in patients with severe preeclampsia. Severe preeclampsia is a leading cause of maternal death and illness worldwide, often causing fluid buildup that can lead to a serious complication called pulmonary edema, especially after delivery.
The study will be a prospective, longitudinal observational study with a diagnostic validation component. It will involve patients with a diagnosis of severe preeclampsia who meet specific inclusion criteria. Each participant will undergo a clinical exam and a lung ultrasound, which will assess eight zones of the lungs. The total number of B-lines-a sign of interstitial edema-will be documented.
Data will be collected at three key times: upon admission, in the immediate postpartum period (within 24 hours of delivery), and 7-10 days postpartum. The results from the LUS will be compared to clinical signs like shortness of breath, rapid breathing, crackling sounds in the lungs, and oxygen saturation levels.
The expected impact of this research is to provide evidence that LUS is a valuable, non-invasive, and accessible tool for the early detection of pulmonary congestion in patients with severe preeclampsia. This could lead to improved clinical decision-making and a reduction in maternal respiratory complications.
916 studies on the registry are indexed under Pre-Eclampsia; 243 are open to participants now.
This study's planned enrollment of 202 is above the median of 110 across 480 interventional studies indexed under Pre-Eclampsia.
Browse Pre-Eclampsia studies →Saint Thomas Hospital, Panama is the lead sponsor of 37 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Pregnant subjects (24 weeks - 41 weeks) with severe preeclampsia
Diagnostic Test: Lung ultrasound
Lung ultrasounf at three moments (at admission, before delivery and immediate post partum) to determine B Lines
Lung Ultrasound evaluation
Three or more B Lines in at least two lung zones using lung ultrasound
Time frame: One evaluation at admission, another one just before delivery and a final one 24 hours after delivery
Dyspnea
Subjective sensation of difficulty breathing
Time frame: Report of the symptom by the patient from admission for up to three days
Tachypnea
Respiratory rate above 20 breaths/min
Time frame: Report of the symptom from admission for up to three days.
Oxygen saturation
Oxygen saturation measured by pulse oxymeter
Time frame: Report of the value measured by a pulse oxymeter from admission for up to three days
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2025 (actual). Primary completion is estimated for Dec 2025, 4 months after the start.
Of 171 non-industry interventional studies with no phase under Pre-Eclampsia, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 43. This study's planned 4 months is below that.
Counting every sponsor, half of 176 studies reached it within 24 months; a quarter within 9 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
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Saint Thomas Hospital, Panama