CClinicalTrials.gg
RecruitingNCT06107257CAPEUpdated Oct 30, 2023

Cardiogenic Acute Pulmonary Edema in Subjects Over 75 Years Old: Impact of Non-invasive Ventilation on Mortality

An observational study in Cardiogenic Pulmonary Edema, sponsored by University Hospital, Strasbourg, France. Recruiting at 1 site in France. Open to participants aged 76 Years and older. Per ClinicalTrials.gov, last updated 2023-10-30.

Sponsored by University Hospital, Strasbourg, France · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2023, 2 years 10 months ago, but the record still lists the study as recruiting.
  • Started Feb 2023; still recruiting 3 years 8 months later.
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
200
Ages
76 Years and older
Sex
All
01

Study summary

People aged over 75 represent almost 10% of the general population, and 12 to 14% of patients consulting emergency departments. Cardiogenic acute pulmonary edema (APO) is a very common reason for admission to the emergency room. The effectiveness of non-invasive ventilation (NIV) has been demonstrated during the management of PAO and would allow, compared to medical treatment alone, a more rapid improvement in clinical and gasometric parameters as well as a reduction in the need for ventilation. orotracheal intubation. On the other hand, the impact of NIV on mortality in cardiogenic PAO seems poorly defined, with lower levels of scientific evidence regarding a possible benefit in terms of survival, particularly in the elderly population.

The objective of this study is to determine whether the use of NIV in cardiogenic PAO in elderly subjects admitted to the emergency room of Strasbourg University Hospital would have an impact in terms of mortality up to 6 months compared to medical treatment alone.

02

Conditions studied

  • Cardiogenic Pulmonary Edema

Keywords

  • Cardiogenic Pulmonary Edema
  • Acute pulmonary edema
  • Non-invasive ventilation
03

In context

Pulmonary Edema

138 studies on the registry are indexed under Pulmonary Edema; 24 are open to participants now.

This study's planned enrollment of 200 is above the median of 118 across 57 observational studies indexed under Pulmonary Edema.

Browse Pulmonary Edema studies →

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 966 studies on the registry; 342 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
76 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Adult subject (> 75 years) with a diagnosis of cardiogenic PAO treated at Strasbourg University Hospital between January 1, 2021 and October 31, 2021

Inclusion criteria

  • Adult subject (> 75 years old)
  • Admission to the NHC emergency room between January 1, 2021 and October 31, 2021
  • Diagnosis of cardiogenic PAO
  • Indication of NIV according to current recommendations
  • Subject not opposing the reuse of their data for scientific research purposes.

Exclusion criteria

Exclusion Criteria:

  • Subject having expressed his opposition to the reuse of his data for scientific research purposes.
  • Presence of an absolute contraindication to NIV
  • Respiratory distress due to pneumonia or other diagnosis
  • RT-PCR Sars Cov 2 positive in emergency
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
200 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Survival Analysis

    Time frame: 6 months after cardiogenic acute pulmonary edema

07

Study locations

1 of 1 sites recruiting
  • Gériatrie - Service de Soins de Soins Médicaux et de Réadaptation - CHU de Strasbourg - France
    Strasbourg, 67091, France
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 30, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06107257
Lead sponsor
University Hospital, Strasbourg, France
Responsible party
Sponsor
First posted
Oct 30, 2023
Start date
Feb 1, 2023
Primary completion
Dec 2023 (estimated)
Completion
Dec 31, 2023 (estimated)
Last update
Oct 30, 2023

Study contacts

Elise SCHMITT, MD
Contact
elise.schmitt@chru-strasbourg.fr
33 3 88 11 58 84

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion