An observational study in Postoperative Nausea and Vomiting, sponsored by Ankara Etlik City Hospital. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 3 Years to 12 Years. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by Ankara Etlik City Hospital · Observational
Postoperative nausea and vomiting (PONV) is one of the common complications in the pediatric patient group. Laparoscopic surgeries further increase the risk of postoperative nausea and vomiting due to increased intra-abdominal pressure and carbon dioxide use. In this study, gastric volume will be measured by ultrasonography in the preoperative period in order to investigate whether the fullness of the stomach and gastric volume are related to the predictability of postoperative nausea and vomiting. This study may contribute to clinical practices in predicting postoperative nausea and vomiting and developing preventive strategies in children aged 3-12 years undergoing laparoscopic appendectomy.
Postoperative nausea and vomiting is one of the complications frequently encountered in pediatric patients that seriously affects patient comfort. In the literature, the incidence of postoperative nausea and vomiting in the pediatric population is reported to be between 20-50%. This situation reduces patient satisfaction and prolongs discharge times.
Aspiration of stomach contents into the lungs, although its frequency varies in children, is seen between 0.02-0.1% in elective surgeries and can result in severe situations such as the need for mechanical ventilation and hypoxia. Although many factors have been investigated to evaluate the risk of aspiration and predict postoperative nausea and vomiting, the role of gastric volume, which is a physiological parameter, in this regard has not been sufficiently elucidated. A limited number of studies in adults have found a significant relationship between preoperative increased stomach volume and postoperative nausea and vomiting. However, there is not enough data examining this relationship in the pediatric age group. This study aims to contribute to the literature, to determine patients at risk of postoperative nausea and vomiting by measuring preoperative stomach volumes, and to develop preventive strategies. The case group in this study; There will be ASA I, II, III children between the ages of 3-12 who will undergo laparoscopic appendectomy surgery performed by the Pediatric Surgery unit in the Pediatric Operating Room. As a result of the power analysis performed using the G*Power 3.1.9.7 program, a total of at least 118 samples was found to be sufficient with 95% power and 5% margin of error (n1=59- n2=59). The study included the pediatric age group. For this reason, informed consent will be obtained from the family or legal representatives and verbal information will be given to the children appropriate to their age. Patients' age, gender, comorbidities, regular medications, height, weight, fasting period before anesthesia, history of motion sickness Patients will be evaluated in terms of nausea and vomiting, including ASA score, preoperative gastric volume, intraoperative heart rate every 15 minutes, blood pressure, saturation, end-tidal carbon dioxide value, intra-abdominal pressure value applied during laparoscopy, in the postoperative recovery room (0th hour), 6th and 24th hours. The identity information of the participants in this research will not be included in the report, thesis or scientific publication. All individuals will be identified anonymously in the study and each participant will be assigned a code number. History of previous gastrointestinal surgery, any history of gastrointestinal system disease, those with developmental or neurological disorders, those with a history of motion sickness or postoperative nausea and vomiting, those with preoperative antiemetic use, and those whose families do not give consent will not be included in the study.
631 studies on the registry are indexed under Postoperative Nausea and Vomiting; 114 are open to participants now.
This study's planned enrollment of 118 is below the median of 193 across 89 observational studies indexed under Postoperative Nausea and Vomiting.
Browse Postoperative Nausea and Vomiting studies →Ankara Etlik City Hospital is the lead sponsor of 174 studies on the registry; 75 are open to participants now.
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Children aged 3-12 years with American Society of Anesthesiologists (ASA) physical status I-III who undergo laparoscopic appendectomy at Etlik City Hospital
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Exclusion Criteria:
Children aged 3-12 years with ASA I-III status undergoing laparoscopic appendectomy who develop postoperative nausea and vomiting during the first 24 hours after surgery. Assessments will be performed at 0, 6 and 24 hours postoperatively. Preoperative gastric volume will be estimated using ultrasonography.
Children aged 3-12 years with ASA I-III status undergoing laparoscopic appendectomy who do not develop postoperative nausea and vomiting during the first 24 hours after surgery. Assessments will be performed at 0, 6 and 24 hours postoperatively. Preoperative gastric volume will be estimated using ultrasonography.
Presence of postoperative nausea and/or vomiting within 24 hours after surgery
Presence of postoperative nausea and/or vomiting within 24 hours after surgery. Nausea will be assessed using child or parent reports. Vomiting will be defined as the observed expulsion of gastric contents.
Time frame: From the end of the surgery through 24 hours postoperatively.
Preoperative gastric volume
The relationship of the following variables with postoperative nausea and vomiting (PONV) was examined: gastric volume (ml) measured via preoperative ultrasonography; gastric volume normalized per kilogram of body weight (ml/kg); the frequency of nausea and vomiting episodes in patients who developed PONV; the need for antiemetic administration due to PONV; the qualitative assessment of preoperative gastric content (empty, liquid, or solid); the duration and feasibility of measuring gastric volume using ultrasonography; as well as the duration of anesthesia, duration of surgery, dosage of opioids administered, age, and gender.
Time frame: Preoperative measurement; PONV status determined during the first 24 hours after surgery.
Plan to share: Undecided
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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