5-HT3 antagonists clinical trials
A class of medicines: the studies that test any of its 14 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones. In MeSH: Serotonin 5-HT3 Receptor Antagonists.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Medicines in this class
Studies that test each. A study of two counts under both, and once above.
- Netupitant, palosentron drug combination
- 12
- Fosrolapitant/Palonosetron
- 2
- Extended-release Granisetron Polymer Formulation
- 1
- Itasetron
- 1
- Lerisetron
- 1
Studies by the year they started
413 studies that test it; most in 2009 (29)
| Year | Studies |
|---|---|
| 1996 | 1 |
| 1998 | 2 |
| 2000 | 2 |
| 2001 | 3 |
| 2002 | 5 |
| 2003 | 9 |
| 2004 | 7 |
| 2005 | 13 |
| 2006 | 20 |
| 2007 | 13 |
| 2008 | 21 |
| 2009 | 29 |
| 2010 | 16 |
| 2011 | 25 |
| 2012 | 17 |
| 2013 | 14 |
| 2014 | 14 |
| 2015 | 19 |
| 2016 | 17 |
| 2017 | 19 |
| 2018 | 20 |
| 2019 | 13 |
| 2020 | 19 |
| 2021 | 20 |
| 2022 | 19 |
| 2023 | 12 |
| 2024 | 13 |
| 2025 | 11 |
| 2026 | 20 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 97 · Other 325
Seoul National University Hospital (12) · Assiut University (12) · Astellas Pharma Inc (10) · Helsinn Healthcare SA (9) · GlaxoSmithKline (9) · Merck Sharp & Dohme LLC (7) · Tanta University (7) · M.D. Anderson Cancer Center (7)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing one of them · 422
- Netupitant/Palonosetron for Prevention of Nausea and Vomiting in Breast Cancer ADC TherapyNot yet recruitingPhase 2Fudan UniversityNCT07918079Written as Netupitant and Palonosetron
- BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to OndansetronRecruitingPhase 4University of Illinois ChicagoNCT04150614Written as Granisetron Transdermal Patch
- Effect of Ondansetron on the Incidence of Spinal Anaesthesia-Induced Hypotension in Elderly Patients Undergoing Fracture Hip SurgeryNot yet recruitingPhase 4Assiut UniversityNCT07914868Written as Ondansetron
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07877519Written as Tropisetron hydrochloride
- Prophylaxis for Emetogenic radioTherapy With AkynzeoNot yet recruitingPhase 2University Health Network, TorontoNCT07882966Written as Akynzeo
- Ondansetron to Prevent Oral Rehydration Failure in Children With CholeraNot yet recruitingPhase 2Public Interest Science CenterNCT07795060Written as Ondansetron
- Effects of Ondansetron Timing During Spinal Anesthesia for Urologic SurgeryNot yet recruitingPhase 4Istanbul UniversityNCT07858149Written as Ondansetron 8 mg
- Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal AnesthesiaRecruitingPhase 4Sanliurfa Education and Research HospitalNCT07740577Written as Ondansetron 4mg
- Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic CholecystectomyRecruitingPhase 4Faisalabad Medical UniversityNCT07638527Written as ondansetron 4 mg
- Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)Not yet recruitingPhase 4Telethon Kids InstituteNCT07777276Written as Ondansetron iv
- The Safety and Efficacy of Ondansetron in Reducing Immune Checkpoint Inhibitor-Related ToxicitiesRecruitingPhase 2First Affiliated Hospital of Wenzhou Medical UniversityNCT07381634Written as ondansetron
- A Simplified Regimen to Prevent Nausea and Vomiting Using Netupitant/Palonosetron in Germ Cell Cancer Patients Receiving ChemotherapyNot yet recruitingEarly Phase 1Ottawa Hospital Research InstituteNCT07662200Written as Netupitant/Palonosetron Hydrochloride
- Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Cesarean SectionRecruitingNot applicableTanta UniversityNCT07511491Written as Ondansetron intravenous
- Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.Not yet recruitingNot applicableMongi Slim HospitalNCT07632144Written as Ondansetron 8 mg
- Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCTNot yet recruitingPhase 2/3Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de MontrealNCT07588217Written as Ondansetron hydrochloride 8 mg IV Q8H
- Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and DyspepsiaRecruitingPhase 2Mayo ClinicNCT03865290Written as Ondansetron 8mg
- Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in TonsillectomyRecruitingNot applicableTanta UniversityNCT07489742Written as Ondansetron intravenous
- Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography PancreatitisRecruitingPhase 3Tanta UniversityNCT06861010Written as Ondansetron
- Post Operative Shivering Following AnesthesiaNot yet recruitingNot applicableSohag UniversityNCT07377903Written as Ondansetron 8 mg
- Ondansetron for the Management of Atrial FibrillationRecruitingPhase 4Indiana UniversityNCT05844501Written as Ondansetron 8mg
See all 422 studies that test one of the 5-ht3 antagonists →
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered6
- Netupitant/Palonosetron for Prevention of Nausea and Vomiting in Breast Cancer ADC TherapyNov 5, 2026NCT07918079
- Effect of Ondansetron on the Incidence of Spinal Anaesthesia-Induced Hypotension in Elderly Patients Undergoing Fracture Hip SurgeryNov 4, 2026NCT07914868
- Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean SectionOct 21, 2026NCT07886151
- Prophylaxis for Emetogenic radioTherapy With AkynzeoOct 20, 2026NCT07882966
- Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean SectionOct 20, 2026NCT07883772
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Codes
What other systems call 5-HT3 antagonists · ClinicalTrials.gg INT008930
- MeSH (NLM) D058831Serotonin 5-HT3 Receptor AntagonistsOne source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D058831 | Serotonin 5-HT3 Receptor Antagonists | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.