Peripheral Arterial Disease clinical trials
The registry lists 1,377 studies for Peripheral Arterial Disease across more than 10 countries. 275 are recruiting or about to start. 961 of them are mainly about Peripheral Arterial Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Chronic Limb-Threatening Ischemia: 1,695 studies, 328 open.
ClinicalTrials.gov finds 2,355 studies for Peripheral Arterial Disease. How that becomes 1,377 here
This page counts the studies the registry files under Peripheral Arterial Disease, and those it files under no condition that list Peripheral Arterial Diseasethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,355Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −314Filed under a narrower condition, counted on its own pageChronic Limb-Threatening Ischemia 217 · Intermittent Claudication 97
- −7List Peripheral Arterial Disease as a condition, but the registry did not file them under itMost often written as “PAD - Peripheral Arterial Disease” (4), “Symptomatic Peripheral Artery Disease (Symptomatic PAD)” (1), and “Occlusive Peripheral Arterial Disease” (1). The registry filed them under other conditions only, most often Coronary Artery Disease (1) and Peripheral Vascular Diseases (1).
- −657Match it another way61 name it in the title, 1 in a keyword, and 595 by a synonym or other text the search reads.
- 1,377The count on this page15 of them list Peripheral Arterial Disease in their own words; the registry filed them under no condition.
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Status
Who runs them
Northwestern University (26) · University Hospital, Angers (24) · Medtronic Endovascular (21) · VA Office of Research and Development (16) · C. R. Bard (15) · Spectranetics Corporation (15) · Cook Group Incorporated (14) · University of Nebraska (12)
What is being tested here
Drugs under test in Peripheral Arterial Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Aspirin | 4 | 3 | 13 |
| Rivaroxaban | 3 | 2 | 12 |
| Clopidogrel | 3 | 3 | 10 |
| Colchicine | 3 | 2 | 4 |
| Metformin | 2 | 2 | 5 |
| Ticagrelor | 1 | 4 | 10 |
| Carnosine | 1 | 0 | 4 |
| Nicotinamide-beta-riboside | 1 | 2 | 3 |
| Temsirolimus | 1 | 1 | 2 |
| Pegulicianine | 1 | 0 | 1 |
Drug classes tested here P2Y12 inhibitors 3 open · Factor Xa inhibitors 3 open · Antimitotic agents 3 open · mTOR inhibitors 2 open · GLP-1 receptor agonists 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026The COCOA-PAD II Trial · Phase 3 · Northwestern University
- Feb 2027MetfOrmin BenefIts Lower Extremities With Intermittent Claudication · Phase 3 · VA Office of Research and Development
- Nov 2026Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils · Medtronic Endovascular
- Nov 2026The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial) · Nipro Vascular Innovations Americas, Inc
- Nov 2026Prevalence of Obstructive Sleep Apnea in Patients With Peripheral Arterial Occlusive Disease · Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
- Nov 2026Fisetin to Reduce Senescence and Mobility Impairment in PAD · Northwestern University
- Nov 2026Adapted Physical Activity in Patients With Lower Limb Peripheral Arterial Disease · Centre Hospitalier le Mans
- Nov 2026Feasibility Study of the Vessel Restoration System (VRS) for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery (SFA) and/or Popliteal Artery (PA) After Sub-optimal Percutaneous Transluminal Angioplasty (PTA) or Atherectomy: REACTIVATE I · Alucent Biomedical
- Dec 2026SIGNATURE Study : DCB (Legflow) vs POBA in Fempop Arteries · Cardionovum GmbH
- Dec 2026An Open Prospective Longitudinal Pulmonary-cardiovascular Cohort Study · Region Skane
Who these studies take
Of the 192 Peripheral Arterial Disease studies recruiting now, 138 (72%) set no upper age limit and 9 (5%) stop at 75 or younger. 13 (7%) take children under 18. 0 (0%) are for women only and 3 (2%) for men only; 19 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 13 (7%) | 13 (7%) |
| 18 | 142 (74%) | 143 (74%) |
| 30 | 158 (82%) | 160 (83%) |
| 40 | 172 (90%) | 174 (91%) |
| 50 | 186 (97%) | 188 (98%) |
| 65 | 188 (98%) | 191 (99%) |
| 75 | 185 (96%) | 188 (98%) |
| 85 | 164 (85%) | 166 (86%) |
Across all 1,377 studies, recruiting or not: 6% stop at 75 or younger and 2% at 65; 5% take children; <1% are for women only and 1% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Peripheral Arterial Disease studies take
Of 28 phase 4 interventional studies under Peripheral Arterial Disease, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 27 mo9–41 · 26 studies | — | — |
| Phase 2 | 48 mo22–61 · 27 studies | — | — |
| Phase 3 | 51 mo37–58 · 26 studies | — | — |
| Phase 4 | 35 mo18–56 · 28 studies | — | — |
| Interventional, no phase | 31 mo17–55 · 385 studies | 28 mo14–45 · 125 studies | 33 mo17–64 · 260 studies |
| Observational | 36 mo22–73 · 196 studies | 31 mo17–39 · 58 studies | 40 mo24–116 · 138 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted1
- Observational Study to Assess Transradial Access for Treatment in the Lower Extremities.Oct 22, 2026NCT04371861
Stopped3
- Clinical Performance of the VESTO® Vascular Stent for Treatment of Iliac Peripheral Obstructive Arterial DiseaseSuspendedNov 2, 2026NCT06573437
- Shortwave Diathermy In-home Treatment for Indianapolis VA-only Patients Diagnosed With Peripheral Artery Disease and Peripheral NeuropathyWithdrawnOct 29, 2026NCT07336381
- Foot Perfusion Analysis to Predict Limb SalvageTerminatedOct 22, 2026NCT03810469
Newly registered7
- Daily Stretching to Improve Walking in Older Patients With Peripheral Artery Disease: The STRETCH PAD StudyNov 5, 2026NCT07919483
- A Bioequivalence and Safety Study of AJU-B718 and B718R in Healthy Adult Volunteers Under Fasting ConditionsOct 28, 2026NCT07901088
- Plantar Load Analysis of Neuropathic and Neuroischaemic Diabetes-Related Foot UlcerationOct 28, 2026NCT07901478
- The Effect of a Multimodal Preventive Intervention in Patients With Asymptomatic Peripheral Artery DiseaseOct 27, 2026NCT07897396
- Preventing Kidney Injury Using Carbon Dioxide as Contrast Medium in Patients With Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) Having Arterial InterventionOct 23, 2026NCT07891988
Show 2 moreShow fewer
- Construction and Empirical Research of a Risk Prediction Model for Preventing Lower Extremity Arteriosclerosis Obliterans in Diabetic Patients Based on the HAPA ModelOct 19, 2026NCT07881588
- Exploring the Exercise Fear Experiences of Patients With Peripheral Arterial Disease: A Qualitative StudyOct 16, 2026NCT07877129
Studies
Recruiting first, then most recently updated. Showing 50 of 1,377. Browse all 1,377 → or search them.
- Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery PlaquesNot yet recruitingNCT06957821Early Phase 11 country
- Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery DiseaseRecruitingNCT07318610Phase 32 countries
- Daily Stretching to Improve Walking in Older Patients With Peripheral Artery Disease: The STRETCH PAD StudyNot yet recruitingNCT07919483Not applicable1 country
- Truway Diagnostic Tools in Primary CareEnrolling by invitationNCT07209527Early Phase 11 country
- The THOR IDE StudyRecruitingNCT05916950Not applicable1 country
- Efficacy and Safety of Orforglipron in Participants With Peripheral Artery DiseaseRecruitingNCT07223593Phase 318 countries
- REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical CenterRecruitingNCT07223437Not applicable1 country
- EVERO Drug-coated Balloon (DCB) Randomized TrialRecruitingNCT07144150Not applicable1 country
- REducing Systemic Inflammation With LOw-dose Colchicine to ImproVE Cardiovascular Calcification in Chronic Kidney Disease: A Pilot Randomized Open-Label TrialNot yet recruitingNCT07654231Phase 21 country
- PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility StudyNot yet recruitingNCT053773201 country
- Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent RestenosisNot yet recruitingNCT072772181 country
- Personalised Multicomponent Exercise Programme in Peripheral Arterial DiseaseRecruitingNCT06410521Not applicable1 country
- A Bioequivalence and Safety Study of AJU-B718 and B718R in Healthy Adult Volunteers Under Fasting ConditionsNot yet recruitingNCT07901088Phase 11 country
- Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial DiseaseRecruitingNCT03622359Not applicable1 country
- IV-X Medical Peripheral Intravascular Lithotripsy Study for PADNot yet recruitingNCT07746362Not applicable
- Construction and Empirical Research of a Risk Prediction Model for Preventing Lower Extremity Arteriosclerosis Obliterans in Diabetic Patients Based on the HAPA ModelRecruitingNCT07881588Not applicable1 country
- Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable CoilsEnrolling by invitationNCT076398531 country
- Vessel Recoil in Specific CLTI PopulationsRecruitingNCT074656271 country
- DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial DiseaseNot yet recruitingNCT07764016Not applicable
- Hemodynamic Characteristics of Peripheral Arterial Disease Using Computational Fluid DynamicsNot yet recruitingNCT078601381 country
- Improving Mobility After Revascularization in Peripheral Artery DiseaseRecruitingNCT06686121Phase 31 country
- Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and ProgressionRecruitingNCT062063696 countries
- Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular RiskRecruitingNCT04774159Phase 310 countries
- Passive Calf Stretching Therapy in Peripheral Artery DiseaseRecruitingNCT06041880Not applicable1 country
- Automated ABPI in Peripheral Arterial Disease a Pilot StudyRecruitingNCT078503491 country
- Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular InterventionNot yet recruitingNCT07848113Not applicable
- REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients With Chronic Limb-threatening IschemiaRecruitingNCT072705751 country
- ORbital Atherectomy for Lesion Preparation in Patients With Chronic Limb-threatening ischEmiaRecruitingNCT072705621 country
- Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)RecruitingNCT05485961Phase 2/335 countries
- Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel ImagingRecruitingNCT074720491 country
- Intravascular Ultrasound for Peripheral Artery Disease RevascularizationRecruitingNCT06979284Not applicable1 country
- Detecting Peripheral Artery Disease With the PulseRecruitingNCT07226193Not applicable1 country
- Clinical Value of CT Perfusion in Peripheral Artery DiseaseNot yet recruitingNCT07816757
- Advanta VXT and Flixene PMCF RegistryRecruitingNCT071615832 countries
- Intervascular Post-Market Clinical Follow-Up (PMCF) RegistryRecruitingNCT073229134 countries
- Personalizing Thromboprophylaxis for Patients With Peripheral Artery DiseaseRecruitingNCT07613840Not applicable1 country
- Multimodal Physiologic State Intelligence StudyEnrolling by invitationNCT078141181 country
- A Single Arm Trial to Evaluate the Safety and Efficacy of the Long (> 150mm) PasseoTM-18 LuxTM Drug-coated Balloon in the Treatment of Subjects With Infrainguinal Stenotic, Restenotic or Occlusive LesionsRecruitingNCT07385573Not applicable1 country
- Community-based Exercise Following Revascularization for PADRecruitingNCT04252950Not applicable1 country
- Rotational Atherectomy and Drug-Coated Balloon Angioplasty With Embolic Protection for Superficial Femoral Artery OcclusionsNot yet recruitingNCT07803718Not applicable1 country
- Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.RecruitingNCT06437028Not applicable1 country
- Comparison of Clopidogrel-based Antiplatelet Agent Treatment and Aspirin Plus Low Dose Rivaroxaban TherapyRecruitingNCT07796217Phase 41 country
- Impact of Virtual Reality on Patient Pain During Lower Limb Revascularization Via Endovascular Surgery Under Local Anesthesia With SedationRecruitingNCT07181434Not applicable1 country
- The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)RecruitingNCT06321575Not applicable1 country
- Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular SurgeryNot yet recruitingNCT07786623
- The NICE-PAD II TrialNot yet recruitingNCT07782671Phase 3
- FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial DiseaseNot yet recruitingNCT00424866Phase 1/21 country
- Leg Heat Therapy in Peripheral Artery DiseaseRecruitingNCT05465070Not applicable1 country
- CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral LesionsRecruitingNCT051454781 country
- Health for Hungary (H4H) - Longitudinal Collection of Blood Samples and Corresponding DataRecruitingNCT077430211 country