Chronic Limb-Threatening Ischemia clinical trials

The registry lists 357 studies for Chronic Limb-Threatening Ischemia across more than 10 countries. 72 are recruiting or about to start. 294 of them are mainly about Chronic Limb-Threatening Ischemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed: 157
Status unknown: 70
Recruiting: 49
Terminated: 30
Not yet recruiting: 18
Active, not recruiting: 16

Phase

Phase 2: 71
Phase 1: 49
Phase 3: 28
Phase 4: 20
Early Phase 1: 5

Where

United States: 105
Germany: 32
Italy: 24
China: 23
United Kingdom: 22
France: 22

Who runs them

Assiut University (8) · AnGes USA, Inc. (6) · Abbott Medical Devices (5) · Flanders Medical Research Program (5) · Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud (5) · Medtronic Endovascular (4) · LimFlow, Inc. (4) · Ospedale San Donato (4)

What is being tested here

Drugs under test in Chronic Limb-Threatening Ischemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Rivaroxaban	1	0	2
Colchicine	1	1	1
Temsirolimus	1	1	1
Zirconium-89	1	0	1
Treprostinil	0	2	4
Beperminogene perplasmid	0	1	3
Edetic Acid	0	1	2
Donaperminogene seltoplasmid	0	0	2
Emiplacel	0	1	2
Dexamethasone	0	0	1

Drug classes tested here Factor Xa inhibitors 1 open

Coming up

3phase 3 studies under way

26studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Dec 2026Trial to Assess Chelation Therapy in Critical Limb Ischemia · Phase 3 · Mt. Sinai Medical Center, Miami
Nov 2026FastWire REvascularisation of Extremities, (For LOWer Limbs) - FREEFLOW · Versono Medical Ltd
Nov 2026Laser Atherectomy and Sirolimus-eluting Balloon Angioplasty for CLTI · Attikon Hospital
Dec 2026NOrmoBaric Oxygen Therapy Use In Critical Limb ISchemia · University Hospital, Angers
Dec 2026Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease · Maria Cecilia Hospital
Dec 2026Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients · Johns Hopkins University
Dec 2026Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease · Laval University
Dec 2026The PORTuguese Registry of Supera Supported Femoral-Fopliteal Revascularization (SupPORT Registry) · Hospital do Divino Espírito Santo de Ponta Delgada
Dec 2026CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions · Yale University
Dec 2026Evaluation of the MAGNITUDE® Bioresorbable Drug-Eluting Scaffold in the Treatment of Patients With Below the Knee Disease in Australia · R3 Vascular Inc.

Who these studies take

Of the 49 Chronic Limb-Threatening Ischemia studies recruiting now, 33 (67%) set no upper age limit and 2 (4%) stop at 75 or younger. 3 (6%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (10%) take healthy volunteers.

Recruiting studies that take each age, of 49
Age	Women	Men
10	3 (6%)	3 (6%)
18	41 (84%)	41 (84%)
30	45 (92%)	45 (92%)
40	48 (98%)	48 (98%)
50	48 (98%)	48 (98%)
65	49 (100%)	49 (100%)
75	47 (96%)	47 (96%)
85	45 (92%)	45 (92%)

Across all 357 studies, recruiting or not: 5% stop at 75 or younger and 2% at 65; 6% take children; 0% are for women only and <1% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Chronic Limb-Threatening Ischemia studies take

Of 71 interventional studies with no phase under Chronic Limb-Threatening Ischemia, half reached primary completion within 33 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	33 mo19–85 · 71 studies	—	—
Observational	34 mo22–59 · 51 studies	—	41 mo22–60 · 46 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Stopped1

Foot Perfusion Analysis to Predict Limb SalvageTerminatedOct 22, 2026NCT03810469

Newly registered1

Perioperative Limb Oxygenation Monitoring in Patients With CLTINov 12, 2026NCT07931768

Studies

Recruiting first, then most recently updated. Showing 50 of 357. Browse all 357 → or search them.