An observational study in Peripheral Artery Disease, sponsored by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Observational
Obstructive sleep apnea syndrome (OSAS) is characterized by partial (hypopnea) or complete (apnea) obstruction of the upper airways, leading to intermittent hypoxemia and sleep fragmentation. Peripheral arterial occlusive disease (PAOD) is a chronic condition defined by the narrowing or occlusion of arteries in the lower limbs, often resulting in ischemia of downstream tissues. This disease is a common complication of atherosclerosis and affects approximately 1.2% of the general French population.
OSAS is a well-established risk factor for atherosclerotic disease, particularly for coronary and neurovascular events. Although a relationship between OSAS and PAOD has been investigated in recent years, the link has not been definitively established and requires further study. Therefore, this preliminary cohort study aims to observe the prevalence of OSAS among patients diagnosed with PAOD, regardless of the disease stage.
Patients with a confirmed diagnosis of PAOD, seen either during hospitalization or in an outpatient vascular medicine consultation.
Exclusion Criteria:
Patients hospitalized or seen in vascular medicine consultation with a diagnosis of PAOD at all stages (operated or not) according to the Leriche and Fontaine classification.
Proportion of patients diagnosed with OSAS
Patients diagnosed with OSAS by polygraphy, regardless of severity.
Time frame: Up to 1 month
Proportion of patients diagnosed with OSAS, stratified by the presence or absence of cardiovascular comorbidities.
The prevalence of OSAS will be analyzed in patients with PAOD, stratified by the presence or absence of cardiovascular involvement (e.g., carotid plaque, carotid stenosis, or abdominal aortic aneurysm).
Time frame: Up to 1 month
Ankle-brachial index
The Ankle-Brachial Index (ABI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI): * Mild: 5 to 14 events per hour * Moderate: 15 to 30 events per hour * Severe: \> 30 events per hour
Time frame: Day 0
Toe-brachial index
The toe-Brachial Index (TBI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI): * Mild: 5 to 14 events per hour * Moderate: 15 to 30 events per hour * Severe: \> 30 events per hour
Time frame: Day 0
Proportion of patients diagnosed with OSAS according to PAOD severity
The prevalence of OSAS (diagnosed by polygraphy) will be analyzed according to the severity stage of PAOD.
Time frame: Up to 1 month
Plan to share: No
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Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer