Atherosclerosis clinical trials
The registry lists 1,517 studies for Atherosclerosis across more than 10 countries. 224 are recruiting or about to start. 706 of them are mainly about Atherosclerosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Peripheral Arterial Disease: 3,101 studies, 534 open.
ClinicalTrials.gov finds 3,627 studies for Atherosclerosis. How that becomes 1,517 here
This page counts the studies the registry files under Atherosclerosis, and those it files under no condition that list Atherosclerosisthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 3,627Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,481Filed under a narrower condition, counted on its own pagePeripheral Arterial Disease 1,264 · Chronic Limb-Threatening Ischemia 216 · Intermittent Claudication 1
- −293List Atherosclerosis as a condition, but the registry did not file them under itMost often written as “Coronary Atherosclerosis” (63), “Carotid Atherosclerosis” (53), and “Intracranial Atherosclerosis” (44). The registry filed 13 of them under no condition at all, and the others under other conditions only, most often Coronary Artery Disease (125) and Intracranial Arteriosclerosis (67).
- −336Match it another way242 name it in the title, 43 in a keyword, and 51 by a synonym or other text the search reads.
- 1,517The count on this page29 of them list Atherosclerosis in their own words; the registry filed them under no condition.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Heart, Lung, and Blood Institute (NHLBI) (91) · GlaxoSmithKline (32) · Novartis Pharmaceuticals (22) · Massachusetts General Hospital (20) · Boston Scientific Corporation (20) · AstraZeneca (17) · Korea University (15) · Organon and Co (14)
What is being tested here
Drugs under test in Atherosclerosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Colchicine | 6 | 4 | 16 |
| Aspirin | 4 | 4 | 21 |
| Inclisiran | 3 | 8 | 16 |
| Metformin | 3 | 2 | 8 |
| Ezetimibe | 2 | 6 | 22 |
| Evolocumab | 2 | 0 | 8 |
| Atorvastatin | 1 | 6 | 24 |
| Clopidogrel | 1 | 3 | 10 |
| Bempedoic acid | 1 | 6 | 7 |
| Alirocumab | 1 | 1 | 5 |
Drug classes tested here Antimitotic agents 6 open · Statins 5 open · NSAIDs 4 open · PCSK9 inhibitors 3 open · P2Y12 inhibitors 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease · Phase 3 · NewAmsterdam Pharma
- Jan 2027A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event · Phase 3 · AstraZeneca
- Feb 2027Nicorandil in Atherosclerosis Risk in Patients With Rheumatoid Arthritis · Phase 3 · Tanta University
- Feb 2027MetfOrmin BenefIts Lower Extremities With Intermittent Claudication · Phase 3 · VA Office of Research and Development
- May 2027Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease · Phase 3 · Novartis Pharmaceuticals
- Sep 2027Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Nov 2026LATAM LOWERS LDL-C · Novartis Pharmaceuticals
- Nov 2026Evaluation of a Diagnostic Software for Coronary Artery Disease Using Retrospective CCTA Data (CODEX-1 Study) · Instituto de Investigación Biomédica de Salamanca
- Dec 2026Statins and prOgression of Coronary atheRosclerosis in melanomA Patients Treated With chEckpoint inhibitorS · Monash University
- Dec 2026Guideline Oriented Approach To Lipid Lowering In Asia-Pacific · Stephen Nicholls
Who these studies take
Of the 161 Atherosclerosis studies recruiting now, 84 (52%) set no upper age limit and 33 (20%) stop at 75 or younger. 16 (10%) take children under 18. 2 (1%) are for women only and 3 (2%) for men only; 33 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 14 (9%) | 13 (8%) |
| 18 | 99 (61%) | 100 (62%) |
| 30 | 121 (75%) | 121 (75%) |
| 40 | 138 (86%) | 139 (86%) |
| 50 | 151 (94%) | 153 (95%) |
| 65 | 150 (93%) | 152 (94%) |
| 75 | 139 (86%) | 140 (87%) |
| 85 | 106 (66%) | 106 (66%) |
Across all 1,517 studies, recruiting or not: 25% stop at 75 or younger and 13% at 65; 12% take children; 3% are for women only and 5% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Atherosclerosis studies take
Of 55 phase 4 interventional studies under Atherosclerosis, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 12 mo4–41 · 31 studies | — | — |
| Phase 2 | 30 mo12–59 · 46 studies | — | — |
| Phase 3 | 35 mo21–63 · 53 studies | 33 mo21–51 · 36 studies | — |
| Phase 4 | 30 mo17–59 · 55 studies | — | 36 mo24–59 · 45 studies |
| Interventional, no phase | 30 mo17–56 · 197 studies | — | 30 mo17–56 · 177 studies |
| Observational | 62 mo31–153 · 169 studies | — | 84 mo34–158 · 144 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting1
- A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular DiseaseNov 10, 2026NCT07839936
Newly registered8
- Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD)Nov 5, 2026NCT07920133
- EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular DiseaseNov 4, 2026NCT07914777
- PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite)Nov 4, 2026NCT07916883
- Effect of Anifrolumab on Arterial Inflammation in Systemic Lupus Erythematosus StudyNov 3, 2026NCT07913919
- A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Italy)Oct 30, 2026NCT07906132
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- A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Netherlands)Oct 29, 2026NCT07905508
- A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Spain)Oct 29, 2026NCT07905534
- Vascular Inflammation in Atherosclerosis - Whole Body Molecular PET/CT Imaging Using Folate Receptor βOct 16, 2026NCT07877324
Studies
Recruiting first, then most recently updated. Showing 50 of 1,517. Browse all 1,517 → or search them.
- Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)RecruitingNCT07611747Phase 41 country
- A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular DiseaseRecruitingNCT07839936Phase 21 country
- PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosisRecruitingNCT07232069Phase 31 country
- Causes and Natural History of DyslipidemiasRecruitingNCT003537821 country
- Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD)Not yet recruitingNCT07920133Not applicable1 country
- A Phase 2b Clinical Trial of YN001 in Adults With Coronary AtherosclerosisRecruitingNCT07521007Phase 24 countries
- PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite)Not yet recruitingNCT079168831 country
- A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High RiskRecruitingNCT07613294Phase 37 countries
- EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular DiseaseNot yet recruitingNCT07914777Not applicable1 country
- Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular SystemRecruitingNCT011434541 country
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular EventRecruitingNCT07783802Phase 24 countries
- Effect of Anifrolumab on Arterial Inflammation in Systemic Lupus Erythematosus StudyRecruitingNCT07913919Not applicable1 country
- A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac EventsRecruitingNCT07448038Phase 22 countries
- Aggressive Lipid Lowering Therapy in ICI-Treated MelanomaRecruitingNCT07704918Not applicable1 country
- Effects of Pitavastatin or Combination of Pitavastatin and Ezetimibe on Glucose Metabolism Compared to AtoRvastatin in atheroscLerotic Cardiovascular Disease Patients With Metabolic Syndrome: The EZ-PEARL Randomized TrialRecruitingNCT05705804Not applicable1 country
- Pharmacogenomic Informed Statin PrescribingRecruitingNCT06568601Not applicable1 country
- Isometric Resistance Exercise on Accelerated Atherosclerosis in HypertensionRecruitingNCT07665034Not applicable1 country
- Qatar Cardiometabolic CohortNot yet recruitingNCT076759281 country
- Study of the Effect of Innate on the Inflammatory Response to EndotoxinRecruitingNCT011434801 country
- Feasibility of Combination Therapy With Low-dose Statin and Ezetimibe in Patients With Minimal Subclinical AtherosclerosisNot yet recruitingNCT07871604Phase 41 country
- Test 2 Treat: Can we Improve the Testing and Treatment of High Cholesterol in Patients Who Have Been Hospitalized for a Cardiac Event by Providing Education to Doctors and Patients?RecruitingNCT06471036Not applicable1 country
- Vascular Inflammation in Atherosclerosis - Whole Body Molecular PET/CT Imaging Using Folate Receptor βRecruitingNCT07877324Not applicable1 country
- Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy SpecimensNot yet recruitingNCT07865884
- Polygenic Risk Score Implementation and Stratification for Managing Blood PressureRecruitingNCT06962488Not applicable1 country
- Evaluation of an Integrated, Digital, Nurse-led, Remote Monitoring Care Pathway for Cardiovascular Risk ManagementRecruitingNCT072083311 country
- Guideline Oriented Approach To Lipid Lowering In Asia-PacificRecruitingNCT05325034Not applicable9 countries
- New Heart Imaging Techniques to Evaluate Possible Heart DiseaseRecruitingNCT01399385Not applicable1 country
- How Animal and Plant Protein Shakes Change the Body's Nutrient and Health ResponsesRecruitingNCT07121010Not applicable1 country
- Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) ImagingRecruitingNCT035813181 country
- Pudendal Atherosclerosis by IVUS-NIRS in Men With Coronary Artery DiseaseRecruitingNCT07856199Not applicable1 country
- PCSK9 Inhibitors in Hyperlipidemia and AtherosclerosisNot yet recruitingNCT07856264
- wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65Not yet recruitingNCT07849127Not applicable1 country
- Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Followed by an Open-label Patient CohortRecruitingNCT06813339Early Phase 11 country
- Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World StudyNot yet recruitingNCT07840950Not applicable
- Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 DiabetesRecruitingNCT07837934Phase 21 country
- LDL Cholesterol Reduction Following Ezetimibe InitiationRecruitingNCT07839741Phase 41 country
- Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFERecruitingNCT075943921 country
- Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)RecruitingNCT07157774Phase 328 countries
- Phase IIa Clinical Trial of YN001 in Patients With Atherosclerotic Cardiovascular and Cerebrovascular Diseases and Erectile DysfunctionRecruitingNCT07311330Phase 21 country
- Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)RecruitingNCT05485961Phase 2/335 countries
- A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)RecruitingNCT07428473Phase 12 countries
- CHIP in Health and DiseaseNot yet recruitingNCT077805521 country
- Detecting Peripheral Artery Disease With the PulseRecruitingNCT07226193Not applicable1 country
- Nicorandil in Atherosclerosis Risk in Patients With Rheumatoid ArthritisNot yet recruitingNCT07800351Phase 31 country
- Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery DiseaseRecruitingNCT063279841 country
- A Phase III Study To Evaluate the Efficacy And Safety Of HRS9531 In Participants With Atherosclerotic Cardiovascular DiseaseRecruitingNCT07551492Phase 31 country
- Atherosclerotic Plaque Imaging Project (CPIP)RecruitingNCT058218941 country
- PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Volunteer - Dosimetry Study)RecruitingNCT07800481Early Phase 11 country
- Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic HealthNot yet recruitingNCT074742331 country
- Skin Microcirculation in Patients With Lower Limb AtherosclerosisRecruitingNCT07312383Not applicable1 country