Ototoxicity clinical trials
The registry lists 49 studies for Ototoxicity across more than 10 countries. 15 are recruiting or about to start. 19 of them are mainly about Ototoxicity (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Johns Hopkins University (4) · Children's Oncology Group (2) · Assistance Publique - Hôpitaux de Paris (2) · VA Office of Research and Development (2) · TC Erciyes University (2) · Sound Pharmaceuticals, Incorporated (2) · University Hospital, Geneva (1) · Aaron Moberly (1)
What is being tested here
Drugs under test in Ototoxicity studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial · Siriraj Hospital
- Dec 2026Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction · Johns Hopkins University
- Feb 2027OCCUPATIONAL NOISE AND CHEMICAL EXPOSURE EFFECTS ON AUDITORY AND VESTIBULAR FUNCTION · Ondokuz Mayıs University
- Jun 2027Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer · Simon Jäger
- Jun 2027Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted. · Institut de Cancérologie de Lorraine
- Jul 2027Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter Study · Assistance Publique - Hôpitaux de Paris
- Sep 2027Vestibular Implantation in Older Adults · Johns Hopkins University
Who these studies take
Of the 12 Ototoxicity studies recruiting now, 5 (42%) set no upper age limit and 2 (17%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 9 (75%) | 9 (75%) |
| 30 | 11 (92%) | 11 (92%) |
| 40 | 11 (92%) | 11 (92%) |
| 50 | 11 (92%) | 11 (92%) |
| 65 | 12 (100%) | 12 (100%) |
| 75 | 11 (92%) | 11 (92%) |
| 85 | 9 (75%) | 9 (75%) |
Across all 49 studies, recruiting or not: 35% stop at 75 or younger and 27% at 65; 18% take children; 0% are for women only and 4% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
- Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck CancerOct 20, 2026NCT06929468
Studies
Recruiting first, then most recently updated. Showing 49 of 49. search them.
- Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck CancerRecruitingNCT069294681 country
- Prevention of Ototoxicity in NTM Patients Treated With IV AmikacinRecruitingNCT05730283Phase 21 country
- OCCUPATIONAL NOISE AND CHEMICAL EXPOSURE EFFECTS ON AUDITORY AND VESTIBULAR FUNCTIONNot yet recruitingNCT078061231 country
- Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter StudyRecruitingNCT059465771 country
- Maximizing Quality of Life After Cancer Through RehabilitationNot yet recruitingNCT07622407Not applicable1 country
- Long Term Outcomes After Vestibular ImplantationRecruitingNCT06500975Not applicable1 country
- Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled TrialRecruitingNCT07364747Phase 21 country
- Vestibular Implantation in Older AdultsRecruitingNCT05676944Not applicable1 country
- Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular HypofunctionRecruitingNCT05674786Not applicable1 country
- Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young AdulthoodNot yet recruitingNCT06957132Not applicable1 country
- The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of LifeRecruitingNCT065518571 country
- Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular SchwannomaRecruitingNCT056414411 country
- Treatment of Radiation and Cisplatin Induced Toxicities with TempolRecruitingNCT03480971Phase 21 country
- Diagnostic of Various Ototoxicity Induced by Cancer TreatmentRecruitingNCT064900291 country
- Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer PatientsRecruitingNCT06297369Phase 21 country
- Sodium Thiosulfate Otoprotection During Salvage Cisplatin TherapySuspendedNCT05756660Early Phase 11 country
- Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted.Active, not recruitingNCT05936034Not applicable1 country
- SPI-1005 for Prevention and Treatment of Tobramycin Induced OtotoxicityCompletedNCT02819856Phase 21 country
- SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing LossWithdrawnNCT01451853Phase 21 country
- Screening for Hearing Loss After Childhood CancerCompletedNCT06036407Not applicable1 country
- Multichannel Vestibular Implant Early Feasibility StudyActive, not recruitingNCT02725463Not applicable1 country
- Statins Effect on Incidence of Side Effects of Platinum Based ChemotherapyCompletedNCT06553157Phase 1/21 country
- Head and Neck Cancer Survivorship Ototoxicity Screening (SOS)CompletedNCT05789316Not applicable1 country
- Cancer and Hearing Loss Related in ChildrenCompletedNCT024253971 country
- Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on HearingCompletedNCT072544421 country
- Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other MalignancyCompletedNCT00716976Phase 33 countries
- Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced OtotoxicityTerminatedNCT04226456Phase 41 country
- Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer TreatmentCompletedNCT04262336Phase 12 countries
- Evaluation of the Effect of Rosuvastatin on Cisplatin-induced Nephrotoxicity and OtotoxicityStatus unknownNCT04817904Phase 21 country
- The Platinum Study Comparison GroupCompletedNCT028900301 country
- Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma TherapyCompletedNCT01848457Phase 21 country
- Randomized Trial Comparison of Ototoxicity Monitoring ProgramsCompletedNCT02099786Not applicable1 country
- Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver CancerCompletedNCT00652132Phase 31 country
- Protective Role of N-acetylcisteine From Cisplatin-induced Ototoxicity in Patients With Head and Neck CancerCompletedNCT03400709Not applicable1 country
- Dexamethasone in Preventing Hearing Loss in Patients Receiving CisplatinWithdrawnNCT02382068Not applicable
- Assessing Ear Damage in Young Cancer Patients Treated With CisplatinCompletedNCT004588873 countries
- Tinnitus and Arterial HypertensionStatus unknownNCT013336831 country
- Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone TreatmentCompletedNCT01372904Phase 41 country
- Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With CisplatinCompletedNCT00477607Phase 2/31 country
- A Comparison of Infection Rates Between Two Surgical SitesCompletedNCT012632621 country
- Observing Young Patients With Ependymoma Undergoing Standard Combination ChemotherapyActive, not recruitingNCT006833191 country
- Aminoglycoside Plasma Level Measurement in Neonates With InfectionStatus unknownNCT016243241 country
- Protective Effect of N-acetylcysteine Against From OtotoxicityCompletedNCT01271088Phase 2/31 country
- Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin.Status unknownNCT01285674Not applicable1 country
- Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid TumorsStatus unknownNCT01216800Phase 31 country
- The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in HumansCompletedNCT01139281Phase 21 country
- Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-AcetylcysteineCompletedNCT01131468Phase 21 country
- Transtympanic Ringer's Lactate for the Prevention of Cisplatin OtotoxicityStatus unknownNCT01108601Phase 1/21 country
- Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity?Status unknownNCT00578760Not applicable1 country