Drug
Sodium thiosulfate clinical trials
Also written Sodium Hyposulfite.
- studies test it
- 42
- open now
- 7
- in phase 3
- 8
- first study started
- 1999
Keep track of what changes. Save the sodium thiosulfate studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Development codes
Other names
Studies by the year they started
42 studies that test it; most in 2017 (5)
| Year | Studies |
|---|---|
| 1999 | 1 |
| 2003 | 1 |
| 2004 | 3 |
| 2005 | 1 |
| 2007 | 2 |
| 2008 | 2 |
| 2009 | 3 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 2 |
| 2014 | 1 |
| 2015 | 2 |
| 2017 | 5 |
| 2018 | 3 |
| 2020 | 3 |
| 2021 | 4 |
| 2022 | 2 |
| 2023 | 3 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 9
- Phase 2
- 21
- Phase 3
- 8
- Phase 4
- 1
- No phase
- 5
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 39
OHSU Knight Cancer Institute (4) · National Cancer Institute (NCI) (3) · Dana-Farber Cancer Institute (3) · Children's Oncology Group (2) · University Medical Center Groningen (2) · Insel Gruppe AG, University Hospital Bern (2) · Columbia University (1) · Nantes University Hospital (1)
Often tested with
Tested in the same studies.
Cisplatin (10) · Mannitol (4) · Mitomycin (3) · Carboplatin (3) · Etoposide (2) · Etoposide phosphate (2) · Melphalan (2) · Sodium Thiosulfate Formulation DB-020 (1)
Studies
Open first, then newest update. How each study uses sodium thiosulfate is read from its arms, and is right about nine times in ten.
Testing it · 42
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal HistologiesRecruitingPhase 1National Cancer Institute (NCI)NCT04847063Written as Sodium Thiosulfate
- A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing LossRecruitingPhase 3Children's Oncology GroupNCT05382338Written as Sodium Thiosulfate
- Intralesional Injection of STS in Treatment of CalcinosisRecruitingPhase 2Robyn T. Domsic, MD, MPHNCT06672822Written as Sodium Thiosulfate (STS)
- A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT StrategyRecruitingPhase 3Shanghai Children's Medical CenterNCT04478292Written as Sodium Thiosulfate Injection
- Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney TransplantationRecruitingNot applicableAlp SenerNCT06288152Written as Sodium Thiosulfate
- Better Evidence and Translation for CalciphylaxisRecruitingPhase 3University of SydneyNCT05018221Written as Sodium Thiosulfate
- Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin ChemotherapyRecruitingPhase 2Sunnybrook Health Sciences CentreNCT05129748Written as Sodium Thiosulfate + Mannitol
- Sodium Thiosulfate Otoprotection During Salvage Cisplatin TherapySuspendedEarly Phase 1Children's Hospital Medical Center, CincinnatiNCT05756660Written as Sodium Thiosulfate
- Efficacy and Tolerance of Sodium Thiosulfate Injection After Ultrasound-guided Percutaneous Irrigation of Calcific Tendinopathy of the Rotator CuffCompletedPhase 2Nantes University HospitalNCT02538939Written as Sodium thiosulfate
- Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical CarcinomaActive, not recruitingPhase 2Columbia UniversityNCT03127774Written as Sodium thiosulfate
- The Effect of Sodium Thiosulfate Eardrops on Hearing Loss in Patients Who Receive Cisplatin TherapyTerminatedNot applicableSidney Kimmel Cancer Center at Thomas Jefferson UniversityNCT01369641Written as Sodium Thiosulfate (STS)
- Double-blind Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic ArteriolopathyWithdrawnPhase 3American Regent, Inc.NCT02527213Written as Sodium thiosulfate
- Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal CytologyCompletedPhase 2National Cancer Institute (NCI)NCT03092518Written as Sodium Thiosulfate
- Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult DermatomyositisCompletedPhase 2/3National Institute of Environmental Health Sciences (NIEHS)NCT03267277Written as Sodium Thiosulfate
- Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With CisplatinCompletedPhase 2Hyunseok Kang, MDNCT04541355Written as Sodium Thiosulfate
- Evaluation of Thiosulfate in End Stage Renal Disease and Kidney TransplantationCompletedPhase 1London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sNCT04292184Written as Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%
- Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other MalignancyCompletedPhase 3Children's Oncology GroupNCT00716976Written as sodium thiosulfate
- Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer TreatmentCompletedPhase 1Decibel TherapeuticsNCT04262336Written as DB-020
- Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium ThiosulfateWithdrawnPhase 1Insel Gruppe AG, University Hospital BernNCT02624479Written as Sodium thiosulfate
- STS Administration on Coronavirus Disease (COVID-19) Patients in Critical CareStatus unknownPhase 2Hellenic Institute for the Study of SepsisNCT05277285Written as Sodium Thiosulfate 25% Solution for Injection
See all 42 studies that test sodium thiosulfate →
Given in every arm · 6 — sodium thiosulfate is usual care beside what is tested
- Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell TumorsRecruitingPhase 1City of Hope Medical CenterNCT07218913Written as Sodium Thiosulfate Anhydrous
- Heated Intra-peritoneal Chemotherapy with Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric PatientsTerminatedEarly Phase 1Mayo ClinicNCT04213794Written as Sodium Thiosulfate
- Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment RegimenTerminatedPhase 2OHSU Knight Cancer InstituteNCT00074165Written as Sodium thiosulfate
- Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System LymphomaStatus unknownPhase 1/2OHSU Knight Cancer InstituteNCT00293475Written as Sodium Thiosulfate
- BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the BrainWithdrawnPhase 1/2OHSU Knight Cancer InstituteNCT00397501Written as sodium thiosulfate
- Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural MesotheliomaCompletedPhase 1Brigham and Women's HospitalNCT00571298Written as sodium thiosulfate
As the comparator · 1 — what is tested is compared with sodium thiosulfate
Codes
What other systems call sodium thiosulfate · ClinicalTrials.gg INT002684
- MeSH (NLM) C017717sodium thiosulfateConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) HX1032V43MSODIUM THIOSULFATEConfirmed FDA, NLM, Wikidata
- RxNorm 36726One source FDA
- Wikidata Q29563807sodium thiosulfate pentahydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1230Sodium ThiosulfateOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C017717 | sodium thiosulfate | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | HX1032V43M | SODIUM THIOSULFATE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 36726 | — | One source FDA |
| Wikidata | Q29563807 | sodium thiosulfate pentahydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1230 | Sodium Thiosulfate | One source FDA |
Also registered as sodium thiosulfate anhydrous (UNII L0IYT1O31N · RxNorm 1807514).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.