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CompletedNCT07254442Updated Nov 28, 2025

Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing

An observational study in Hearing, COVID - 19 and Ototoxicity, sponsored by Zonguldak Bulent Ecevit University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-28.

Sponsored by Zonguldak Bulent Ecevit University · Observational

Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
90
Ages
18 Years to 35 Years
Sex
All
01

Study summary

Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing

Read the detailed description

This study aims to investigate the impact of medications containing the active ingredients hydroxychloroquine and favipiravir on the auditory system, as well as to examine the effect of COVID-19 on hearing and its potential relationship with medication use and COVID-19 vaccine dose.

02

Conditions studied

  • Hearing
  • COVID - 19
  • Ototoxicity
03

In context

COVID-19

7,990 studies on the registry are indexed under COVID-19; 466 are open to participants now.

This study's enrollment of 90 is below the median of 268 across 3,208 observational studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Zonguldak Bulent Ecevit University is the lead sponsor of 100 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

  1. Those who have had COVID-19 and are taking medication
  2. Those who have had COVID-19 and are not taking medication
  3. Healthy individuals who have not had COVID-19

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Age between 18 and 35 For the Medication group: Having had COVID-19 and using COVID-19 medications For the Non-Medication group: Having had COVID-19 and not using COVID-19 medications For the Control group: Having never had COVID-19

Exclusion criteria

Exclusion Criteria:

Previously diagnosed with hearing loss Use of ototoxic medications other than those specified Pathology detected during tympanometric evaluation or otoscopic examination Chronic disease Family history of hearing loss History of meningitis Neurological disorders Acute or chronic ear infection Admission to intensive care

05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
90 participants (actual)
Patient registry
No

Groups and cohorts

  • Control group

    Group that has not had Covid-19

    Diagnostic Test: Hearing tests

  • Medication Group

    The group that had Covid-19 and used medication

    Diagnostic Test: Hearing tests

  • Non-medication group

    The group that had Covid-19 and did not use medication

    Diagnostic Test: Hearing tests

Interventions

  • Diagnostic testHearing tests

    Participants' pure tone thresholds, high frequency thresholds, and otoacoustic emissions measurements were evaluated.

06

What researchers measure

Primary outcomes

  1. Pure tone and high frequency hearing thresholds

    Time frame: December, 2021-February 2022

  2. Transient evoked otoacoustic emissions - Signal/noise ratio

    Time frame: December, 2021-February 2022

  3. Distortion product otoacoustic emissions- signal/noise ratio

    Time frame: December, 2021-February 2022

07

Study locations

1 site
  • Biruni University
    Istanbul, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Dec 2021 to primary completion in Feb 2022, 2 months.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 26, 2025
First posted
Nov 28, 2025
StartActual
Dec 1, 2021
Primary completionActual
Feb 1, 2022
CompletionActual
Mar 1, 2022
Last update
Nov 28, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 28, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07254442
Responsible party
Azize Arzu KÖROĞLU KOÇYİĞİT (Audiologist, Lecturer, Zonguldak Bulent Ecevit University) — Principal investigator
First posted
Nov 28, 2025
Start date
Dec 1, 2021
Primary completion
Feb 1, 2022
Completion
Mar 1, 2022
Last update
Nov 28, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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