Neoplasms, Unknown Primary clinical trials
The registry lists 104 studies for Neoplasms, Unknown Primary across more than 10 countries. 18 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-16.
Status
- Completed
- 60
- Recruiting
- 15
- Status unknown
- 11
- Active, not recruiting
- 6
- Terminated
- 5
- Not yet recruiting
- 3
Phase
- Phase 2
- 46
- Phase 1
- 21
- Phase 3
- 9
Where
- United States
- 61
- China
- 9
- Denmark
- 8
- Canada
- 7
- Netherlands
- 6
- United Kingdom
- 6
Who runs them
National Cancer Institute (NCI) (18) · M.D. Anderson Cancer Center (6) · SCRI Development Innovations, LLC (5) · Rigshospitalet, Denmark (4) · University Health Network, Toronto (3) · The Christie NHS Foundation Trust (3) · Alliance for Clinical Trials in Oncology (2) · Fox Chase Cancer Center (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 104 — search for more.
- Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible SensitivityRecruitingNCT04273061Phase 21 country
- Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)RecruitingNCT075241141 country
- A Phase II/III Study of F520 Combined With Paclitaxel Plus Carboplatin in the Treatment of Cancer of Unknown Primary (CUP)RecruitingNCT07761429Phase 2/31 country
- Living Without Answers - ILLUMINATE CUPNot yet recruitingNCT07712965
- Integrated Cancer Repository for Cancer ResearchRecruitingNCT020126991 country
- Ontario-wide Cancer TArgeted Nucleic Acid EvaluationRecruitingNCT029069431 country
- TCF-001 TRACK (Target Rare Cancer Knowledge) StudyRecruitingNCT04504604Not applicable1 country
- PaCIFiC-CUP Classifies Cancer of Unknown PrimaryRecruitingNCT061409921 country
- Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck CancerRecruitingNCT030101501 country
- A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)RecruitingNCT05576974Phase 21 country
- Cancer Genetic Testing in Ethnic PopulationsRecruitingNCT04475640Not applicable1 country
- Enabling Genomic Testing in Cancer of Unknown PrimaryRecruitingNCT066954941 country
- 18F-FAPI PET in Cancers of Unknown Primary SiteNot yet recruitingNCT073729631 country
- The NorCUP Trial: Improving Prognosis and Personalized Treatment in Cancer of Unknown Primary (CUP)Not yet recruitingNCT07366008Not applicable1 country
- [18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary OriginRecruitingNCT06644716Not applicable1 country
- Solving Riddles Through SequencingRecruitingNCT050464441 country
- Real-time Targeted Fluorescence Endoscopy for Detection of the Primary Cancer Lesion in Patients With a Metastasis of Unknown Primary Tumor in the Head and NeckRecruitingNCT06100081Not applicable1 country
- FAPI-CUP- Evaluating FAPI as a Novel Radiopharmaceutical for Cancer of Unknown PrimaryRecruitingNCT05263700Not applicable1 country
- HARE-40: HPV Anti-CD40 RNA vaccinECompletedNCT03418480Phase 1/21 country
- Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney DysfunctionActive, not recruitingNCT01366144Phase 11 country
- Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are MetastaticActive, not recruitingNCT02721732Phase 21 country
- Integrated Molecular Profiling in Advanced Cancers TrialActive, not recruitingNCT015054001 country
- Pembrolizumab in Patients With Poor-Prognosis Carcinoma of Unknown Primary Site (CUP)CompletedNCT03391973Phase 21 country
- A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation TherapyCompletedNCT01624220Not applicable1 country
- Trial of Pembrolizumab in Cancer of Unknown PrimaryCompletedNCT03752333Phase 21 country
- Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal CordActive, not recruitingNCT02713269Phase 21 country
- Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)CompletedNCT054614301 country
- Sintilimab in Cancer of Unknown PrimaryCompletedNCT05024968Phase 21 country
- Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various CancersActive, not recruitingNCT04459273Phase 11 country
- A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary SiteCompletedNCT03498521Phase 233 countries
- Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid TumorApproved for marketingNCT04100694
- Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung CancerCompletedNCT022451001 country
- The Registry of Oncology Outcomes Associated with Testing and TreatmentCompletedNCT040284791 country
- Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular CharacteristicsActive, not recruitingNCT04584008Not applicable1 country
- Carcinoma of Unknown Primary (CUP): a Comparison Across Tissue and Liquid BiomarkersCompletedNCT047501091 country
- Surgeon-performed Intraoperative Transoral Ultrasound for Cancer of Unknown PrimaryCompletedNCT05841966Not applicable1 country
- A Study of Nab-paclitaxel-based Doublet as First Line Therapy in Patients With Cancer of Unknown Primary (CUP)CompletedNCT02607202Phase 21 country
- Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit StudyCompletedNCT04456140Phase 11 country
- Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSASCompletedNCT04189107Phase 31 country
- Phase-II Study of Lu177DOTATOC in Adults With STTR(+)Pulmonary, Pheochromocytoma, Paraganglioma, Unknown Primary, Thymus NETs (PUTNET), or Any Other Non-.GEP-NET.WithdrawnNCT04276597Phase 21 country
- APL-501 Study for Select Advanced or Relapsed/Recurrent Solid TumorsCompletedNCT03053466Phase 11 country
- Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown PrimaryStatus unknownNCT05241132Phase 21 country
- Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown PrimaryCompletedNCT03278600Phase 31 country
- PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT01816984Phase 1/21 country
- Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in ChinaStatus unknownNCT049521031 country
- The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)Status unknownNCT038969581 country
- Gemcitabine in Treating Patients With Metastatic Cancer of Unknown PrimaryCompletedNCT00357630Phase 21 country
- Nivolumab/Ipilimumab in Second Line CUP-syndromeStatus unknownNCT04131621Phase 21 country
- Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and NeckCompletedNCT01044433Phase 21 country
- Trial Comparing a Strategy Based on Molecular Analysis to the Empiric Strategy in Patients With CUPCompletedNCT01540058Phase 33 countries