An observational study in Migraine, sponsored by National and Kapodistrian University of Athens. Not yet recruiting at 1 site in Greece. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by National and Kapodistrian University of Athens · Observational
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Among 13 studies in Migraine Disorders with a site in Greece — 3 open to participants now, 3 under way, none of them phase 3. Migraine Disorders · Greece.
Among the 13 studies in Migraine Disorders with a site in Greece, this one is one of 3 that started in 2026, is one of 6 observational ones, and was the 12th registered.
1,657 studies on the registry are indexed under Migraine Disorders; 339 are open to participants now.
Browse Migraine Disorders studies →3 of the 13 studies in Migraine Disorders with a site in Greece are open now. Recruiting first, the newest first:
National and Kapodistrian University of Athens · Sites in Greece
Ages 18–70
National and Kapodistrian University of Athens · Sites in Greece
Ages 18–70
A study can be open while its sites in Greece have not opened yet or have stopped. Only those recruiting at a site in Greece →
Of the 217 Migraine Disorders studies recruiting now, 66 (30%) set no upper age limit and 136 (63%) stop at 75 or younger; 44 take children under 18; 37 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 3 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is below the median of 137 across 331 observational studies indexed under Migraine Disorders.
Median enrollment 477 across the 7 interventional studies, 102 across the 6 observational. Of the 9 that completed or were terminated, 5 (56%) have results posted.
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6 of 13 have an industry lead sponsor. The 8 most frequent:
National and Kapodistrian University of Athens is the lead sponsor of 176 studies on the registry; 54 are open to participants now.
National and Kapodistrian University of Athens has 5 studies filed under Migraine Disorders — fewer than ten, so there is no comparison to draw.
3 of the studies in Migraine Disorders with a site in Greece that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07843745National and Kapodistrian University of AthensAssessment of Head Awareness in Patients With Migraine in the Greek Population | 2027-06-01 |
| NCT07847554National and Kapodistrian University of AthensValidity and Reliability of the Greek WPAI:Migraine | 2027-06-01 |
| NCT07847528National and Kapodistrian University of AthensValidity and Reliability of the Greek Pain Catastrophizing Scale | 2027-06-01 |
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Among the 13 studies in Migraine Disorders with a site in Greece, from their registry updates:
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Migraine is a common neurological disorder that can substantially impair work productivity and daily functioning through both absenteeism and presenteeism. The Work Productivity and Activity Impairment Questionnaire for Migraine (WPAI:Migraine) is a brief patient-reported measure designed to assess migraine-related impairment in work and daily activities. Although the questionnaire has demonstrated validity and reliability in other populations, a validated Greek version is currently unavailable. This study aims to evaluate the validity and reliability of the Greek version of the WPAI:Migraine in individuals with episodic or chronic migraine, thereby providing an appropriate tool for assessing migraine-related work productivity and functional impairment in the Greek population.
Migraine is one of the most common neurological disorders among working-age individuals worldwide and a major cause of lost work productivity. Migraine attacks not only cause pain and associated symptoms but also lead to work absenteeism, reduced productivity, and limitations in daily activities. A study including 31 countries showed that 52% of individuals with at least 4 migraine days per month experienced an overall reduction in work performance due to migraine, and that this was attributable more to presenteeism than absenteeism. The American Migraine Prevalence and Prevention Study reported that the cost of presenteeism was nearly three times that of absenteeism in patients with episodic migraine.
The Work Productivity and Activity Impairment Questionnaire (WPAI) is a brief and widely used patient-reported outcome measure that assesses the impact of chronic diseases on work performance. WPAI:Migraine, a migraine-specific version, has been found to be valid and reliable in American and Arabic populations of patients with episodic and chronic migraine. International Headache Society (IHS) guidelines for preventive treatment trials in episodic and chronic migraine recommend the use of the WPAI. Therefore, it is important to evaluate the impact of migraine not only through clinical parameters but also in terms of productivity and functioning.
In Greece, migraine studies have been conducted at the population level using pharmacological treatments and assessments. However, with regard to daily life and work productivity, there is currently no validated Greek WPAI:Migraine questionnaire available to assess migraine-related productivity loss. Availability of such a scale for the Greek migraine population is important for clinical applications, health-economics research, and evaluation of treatment outcomes.
Aim of the study - Hypotheses to be tested The aim of the present study is to investigate the validity and reliability of the Greek version of the WPAI:Migraine questionnaire in individuals with migraine and to determine whether it can be used as a valid and reliable tool for assessing work productivity and functioning in the Greek population.
Hypotheses:
Hypotheses:
Adults aged 18-70 years with a diagnosis of episodic or chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), confirmed by a specialist neurologist. Participants will be recruited from the Specialized Headache Clinic of Aeginition Hospital in Greece.
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Exclusion Criteria:
Greek Version of the Work Productivity and Activity Impairment Questionnaire for Migraine (WPAI:Migraine)
The validity and reliability of the Greek version of the WPAI:Migraine will be evaluated in patients with migraine. The questionnaire assesses work productivity and activity impairment over the previous 7 days, including absenteeism, presenteeism, overall work impairment, and activity impairment. Higher percentage scores indicate greater impairment.
Time frame: Baseline and 7-14 days after baseline for test-retest reliability.
Migraine-Related Disability
igraine-related disability will be assessed using the MIDAS questionnaire, which evaluates disability over the previous 3 months. The total score is calculated from five items, with higher scores indicating greater migraine-related disability.
Time frame: Baseline
Headache Impact
The impact of headache on daily functioning and quality of life will be assessed using the HIT-6. Total scores range from 36 to 78, with higher scores indicating greater headache impact.
Time frame: Baseline
Migraine-Specific Quality of Life
Migraine-specific quality of life over the previous 4 weeks will be assessed using the MSQv2.1, which includes Role Function-Restrictive, Role Function-Preventive, and Emotional Function domains. Scores are transformed to a 0-100 scale, with higher scores indicating better migraine-specific quality of life.
Time frame: Baseline
Headache Pain Intensity
Headache pain intensity will be assessed using the Visual Analog Scale, ranging from 0 (no pain) to 10 (worst imaginable pain), with higher scores indicating greater pain intensity.
Time frame: Baseline
Plan to share: No — Individual participant data (IPD) are not planned to be made publicly available. Data may be considered for sharing upon reasonable request and subject to applicable ethical and institutional requirements.
Start is estimated for Nov 2026; primary completion for Jun 2027, 7 months later.
Of 132 non-industry observational studies under Migraine Disorders, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 72. This study's planned 7 months is below that.
Counting every sponsor, half of 160 studies reached it within 27 months; a quarter within 13 and three quarters within 63.
Start moved once since we started tracking on Sep 25, 2026: Sep 2026 → Nov 2026, on Oct 8, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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National and Kapodistrian University of Athens →