An observational study in Migraine, sponsored by National and Kapodistrian University of Athens. Not yet recruiting at 1 site in Greece. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by National and Kapodistrian University of Athens · Observational
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Among 13 studies in Migraine Disorders with a site in Greece — 3 open to participants now, 3 under way, none of them phase 3. Migraine Disorders · Greece.
Among the 13 studies in Migraine Disorders with a site in Greece, this one is one of 3 that started in 2026, is one of 6 observational ones, and was the 11th registered.
1,657 studies on the registry are indexed under Migraine Disorders; 339 are open to participants now.
Browse Migraine Disorders studies →3 of the 13 studies in Migraine Disorders with a site in Greece are open now. Recruiting first, the newest first:
National and Kapodistrian University of Athens · Sites in Greece
Ages 18–70
National and Kapodistrian University of Athens · Sites in Greece
Ages 18–70
A study can be open while its sites in Greece have not opened yet or have stopped. Only those recruiting at a site in Greece →
Of the 217 Migraine Disorders studies recruiting now, 66 (30%) set no upper age limit and 136 (63%) stop at 75 or younger; 44 take children under 18; 37 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 3 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 90 is below the median of 137 across 331 observational studies indexed under Migraine Disorders.
Median enrollment 477 across the 7 interventional studies, 102 across the 6 observational. Of the 9 that completed or were terminated, 5 (56%) have results posted.
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6 of 13 have an industry lead sponsor. The 8 most frequent:
National and Kapodistrian University of Athens is the lead sponsor of 176 studies on the registry; 54 are open to participants now.
National and Kapodistrian University of Athens has 5 studies filed under Migraine Disorders — fewer than ten, so there is no comparison to draw.
3 of the studies in Migraine Disorders with a site in Greece that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07843745National and Kapodistrian University of AthensAssessment of Head Awareness in Patients With Migraine in the Greek Population | 2027-06-01 |
| NCT07847554National and Kapodistrian University of AthensValidity and Reliability of the Greek WPAI:Migraine | 2027-06-01 |
| NCT07847528National and Kapodistrian University of AthensValidity and Reliability of the Greek Pain Catastrophizing Scale | 2027-06-01 |
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Among the 13 studies in Migraine Disorders with a site in Greece, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Body perception and awareness may be altered in individuals with chronic pain and may be associated with pain intensity, disability, and pain-related psychological factors. Although alterations in pain processing and cortical organization have been reported in individuals with migraine, head-related perceptual awareness has received limited attention, and practical tools for its assessment are lacking.
The Fremantle Headache Awareness Questionnaire (FreHAQ) was developed to assess altered perception and awareness of the head in individuals with headache. A valid and reliable Greek version of this questionnaire could provide clinicians and researchers with a simple and practical tool for evaluating head awareness in individuals with migraine.
The primary aim of this study is to translate and culturally adapt the Fremantle Headache Awareness Questionnaire into Greek and to evaluate the validity and reliability of the Greek version in individuals with migraine. The study will examine the psychometric properties of the questionnaire, including its reliability and validity. Associations between head awareness and relevant clinical and pain-related characteristics will also be investigated.
This study is expected to determine whether the Greek version of the Fremantle Headache Awareness Questionnaire is an appropriate tool for assessing head awareness in the Greek migraine population.
Body perception is a multidimensional concept that encompasses the management and experience of the body, expressing the relationship between body and mind, and is defined differently across medical fields. At the psychomotor level, body perception is related to the level of awareness associated with mental, emotional, and physical activity, whereas from a neurophysiological perspective it is linked to proprioception and the perception of internal bodily signals. The brain perceives stimuli from both the internal and external environments of the body, which over time are transformed into experiential and learned information. Initially, this information develops at a conscious level through the pyramidal system; however, with repetition and consolidation, it becomes an automated, unconscious function through the extrapyramidal system. Therefore, body perception includes body awareness, body management, and bodily experience, enabling the individual to perceive the body and its environment through internal and external stimuli.
Wand and colleagues proposed a theoretical model for low back pain according to which cognitive and behavioral factors are associated with structural and functional changes in the central nervous system. This model suggests that pain and its future consequences may be attributable to maladaptive neuroplastic changes. Changes in the central nervous system increase pain perception by influencing conscious attention and enhancing the perception of pain, ultimately leading to disability. As a result, an unconscious form of perception develops while conscious perception becomes disturbed. Since pain functions as a protective signal of the organism, its conscious recognition is a fundamental component in the development of body perception.
In chronic pain conditions, painful body regions have been shown to be associated with disturbances in body perception, which in turn contribute to the maintenance and amplification of pain. For example, in cervical or lumbar disorders, disruption of sensorimotor information and a shift in activation from deep to superficial muscles lead to impaired motor control. These conditions may cause altered perception of the size, position, and movement of the affected body part because of asymmetry and increased muscle tension. Assessment and restoration of internal and external body perception, together with enhancement of conscious body awareness, are key therapeutic targets.
However, the literature contains insufficient studies examining body perception specifically in headache. Although imaging studies have confirmed the presence of cortical changes in patients with chronic migraine, methods based on patients' verbal and psychological assessment remain limited. Moreover, the use of imaging techniques in clinical practice is often not feasible because of cost and time constraints. Therefore, the development of a rapid and practical assessment method could be particularly useful for clinicians.
The existing literature does not include studies evaluating the perceptual dimension and nociceptive awareness in chronic migraine. Based on the Fremantle Back Awareness Questionnaire, the "Fremantle Headache Awareness Questionnaire" was developed, and its adaptation and validation in the Greek population may provide a reliable and practical assessment tool. This questionnaire could contribute to the objective evaluation of the effectiveness of therapeutic interventions and support the design of programs aimed at enhancing awareness of the head and headache. Within the scope of the study, the psychometric properties of the questionnaire and possible associations among body perception, nociceptive sensitivity, and beliefs regarding headache will be investigated.
Aim of the study - Hypotheses to be tested Studies have shown that different beliefs regarding the nature of lumbar problems and their future consequences can guide behaviors that may lead to neuroplastic changes. Through regulation of the processing and perception of painful stimuli, the central nervous system may contribute to the resolution of persistent pain. For this reason, the Fremantle Back Awareness Questionnaire was developed to assess perceptual awareness of the lumbar region.
In individuals with chronic pain, changes in body perception are attributed to cortical reorganization. Similarly, patients with chronic migraine have been reported to show reduced cortical thickness in brain regions related to pain processing compared with healthy individuals. However, these structural changes have been reported to be potentially reversible, because appropriate treatment of headache and accompanying symptoms may lead to improvement. Nevertheless, individuals with chronic pain continue their daily lives with disturbed body perception.
Reduced perception has been extensively studied in populations with neck, low back, and knee pain using Fremantle Awareness questionnaires in various countries. These studies found that individuals with pain have lower levels of perception, which are associated with pain intensity, catastrophizing, degree of disability, quality of life, anxiety, depression, and kinesiophobia. In addition, therapeutic intervention has been shown to improve body perception.
Although reversible cortical changes in migraine have been studied using imaging methods, their use in routine clinical practice is limited by cost and time requirements. Therefore, a rapid, practical, and easy-to-use assessment tool could be particularly useful. The literature indicates that there are no studies evaluating proprioceptive awareness of the head in migraine.
Based on the "Fremantle Back Awareness Questionnaire", the "Fremantle Headache Awareness Questionnaire" was developed, and studying its validity and reliability in the Greek population is expected to provide a practical tool for objectively evaluating the effectiveness of therapeutic interventions in clinical practice.
Hypotheses:
Adults aged 18-70 years with a diagnosis of episodic or chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), confirmed by a specialist neurologist. Participants will be recruited from the Specialized Headache Clinic of Aeginition Hospital in Greece.
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Exclusion Criteria:
Individuals diagnosed with migraine who will participate in the cross-cultural adaptation and psychometric evaluation of the Greek version of the Fremantle Headache Awareness Questionnaire (FreHAQ-GR).
Greek Version of the Fremantle Headache Awareness Questionnaire
The psychometric properties of the Greek version of the Fremantle Headache Awareness Questionnaire (FreHAQ-GR) will be evaluated in individuals with migraine. Reliability will be assessed using internal consistency and test-retest reliability. Validity will be evaluated through appropriate construct validity analyses and associations with related clinical measures. Higher FreHAQ scores indicate greater disturbance in head awareness.
Time frame: Baseline and 1 week for test-retest reliability
Headache Intensity
Headache pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain), with higher scores indicating greater pain intensity.
Time frame: Baseline
Migraine-Related Disability
Migraine-related disability will be assessed using the Migraine Disability Assessment (MIDAS), which evaluates days of lost or reduced activity due to migraine during the previous 3 months. Higher scores indicate greater migraine-related disability.
Time frame: Baseline
Headache Impact
The impact of headache on daily functioning and quality of life will be assessed using the six-item Headache Impact Test (HIT-6). Total scores range from 36 to 78, with higher scores indicating greater headache impact.
Time frame: Baseline
Migraine-Specific Quality of Life
Migraine-specific quality of life will be assessed using the 14-item Migraine-Specific Quality of Life Questionnaire Version 2.1 (MSQv2.1), covering Role Function-Restrictive, Role Function-Preventive, and Emotional Function domains. Scores are transformed to a 0-100 scale, with higher scores indicating better migraine-related quality of life.
Time frame: Baseline
Plan to share: No — Individual participant data (IPD) are not planned to be made publicly available. Data may be considered for sharing upon reasonable request and subject to applicable ethical and institutional requirements.
Start is estimated for Nov 2026; primary completion for Jun 2027, 7 months later.
Of 132 non-industry observational studies under Migraine Disorders, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 72. This study's planned 7 months is below that.
Counting every sponsor, half of 160 studies reached it within 27 months; a quarter within 13 and three quarters within 63.
Start moved once since we started tracking on Sep 25, 2026: Sep 2026 → Nov 2026, on Oct 8, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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National and Kapodistrian University of Athens →