Lipodystrophy clinical trials
The registry lists 139 studies for Lipodystrophy across more than 10 countries. 10 are recruiting or about to start. 55 of them are mainly about Lipodystrophy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as HIV-Associated Lipodystrophy Syndrome: 167 studies, 12 open.
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Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (15) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (13) · University of Texas Southwestern Medical Center (7) · Massachusetts General Hospital (5) · Centre Hospitalier Universitaire de la Réunion (5) · I.R.A. Istituto Ricerche Applicate S.p.A. (4) · Kirby Institute (4) · Glaxo Wellcome (3)
What is being tested here
Drugs under test in Lipodystrophy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Metreleptin | 0 | 1 | 7 |
| Human Growth Hormone | 0 | 1 | 4 |
| Tesamorelin | 0 | 2 | 3 |
| Pioglitazone | 0 | 0 | 3 |
| Nelfinavir | 0 | 0 | 3 |
| Rosiglitazone | 0 | 0 | 3 |
| Ritonavir | 0 | 0 | 3 |
| Leptin | 0 | 1 | 2 |
| Pravastatin | 0 | 1 | 2 |
| Efavirenz | 0 | 0 | 2 |
Drug classes tested here Reverse transcriptase inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Jul 2027Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy · Phase 3 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Jun 2027Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Jul 2027Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Aug 2027Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control Study · Assistance Publique - Hôpitaux de Paris
Who these studies take
Of the 7 Lipodystrophy studies recruiting now, 3 (43%) set no upper age limit and 3 (43%) stop at 75 or younger. 5 (71%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (71%) | 5 (71%) |
| 18 | 6 (86%) | 6 (86%) |
| 30 | 6 (86%) | 6 (86%) |
| 40 | 6 (86%) | 6 (86%) |
| 50 | 6 (86%) | 6 (86%) |
| 65 | 6 (86%) | 6 (86%) |
| 75 | 4 (57%) | 4 (57%) |
| 85 | 4 (57%) | 4 (57%) |
Across all 139 studies, recruiting or not: 42% stop at 75 or younger and 32% at 65; 25% take children; 6% are for women only and 2% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lipodystrophy studies take
Of 23 interventional studies with no phase under Lipodystrophy, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 11 mo7–23 · 23 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Safety and Efficacy of Deoxycholate Treatment of Small Fatty Deformities ( SFD)Oct 19, 2026NCT07880301
Studies
Recruiting first, then most recently updated. Showing 50 of 139. Browse all 139 → or search them.
- Effects of Meal Macronutrients on Postprandial LipidsNot yet recruitingNCT07313787Phase 21 country
- Compassionate Use or Expanded Access of MibavademabAvailableNCT04710056
- Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control StudyNot yet recruitingNCT077990121 country
- Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)RecruitingNCT059965361 country
- Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With LipodystrophyRecruitingNCT054190371 country
- MEASuRE: Metreleptin Effectiveness And Safety RegistryRecruitingNCT023256745 countries
- The LD Lync Study - Natural History Study of Lipodystrophy SyndromesRecruitingNCT030872533 countries
- Registry for Patients With LipodystrophyRecruitingNCT0355342016 countries
- The Skin Barrier in Users of Diabetes DevicesRecruitingNCT068569541 country
- Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE"RecruitingNCT06236932Not applicable1 country
- Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyActive, not recruitingNCT02262806Phase 21 country
- Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyActive, not recruitingNCT02262832Phase 31 country
- Low Energy Diet and Familial Partial LipodystrophyCompletedNCT03900286Not applicable1 country
- Safety and Efficacy of Deoxycholate Treatment of Small Fatty Deformities ( SFD)CompletedNCT07880301Phase 41 country
- Impact of Lipodystrophy on the Inflammatory State of Non-diabetic Dunnigan Reunion Island SubjectsCompletedNCT06107439Not applicable1 country
- Expanded Access for Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With LipodystrophyNo longer availableNCT00677313
- Assess the Possibility of Diagnosing Diabetes and Rediabetes Following Oral Induced Hyperglycemia in Patients With Dunnigan's Partial Familial Lipodystrophy by Replacing 75 g of Glucose With a Standardized Carbohydrate Breakfast and Continuous Interstitial Monitoring Glucose)CompletedNCT05789251Not applicable1 country
- Study of the Subdermal Implant "Ultracol"CompletedNCT07617350Not applicable1 country
- Identification of a New Gene Involved in Hereditary LipodystrophyCompletedNCT02056912Not applicable1 country
- Study of the Subdermal Implant "Algeness"CompletedNCT07618468Not applicable1 country
- Redefining Limits: A Clinical Trial on the Safety of Combining Liposuction With Undermining During AbdominoplastyCompletedNCT07590492Not applicable1 country
- Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and ObesityCompletedNCT017842891 country
- Cyclophosphamide in the Treatment of Associated Acquired Lipodystrophy Syndrome With Type 1 DiabetesActive, not recruitingNCT03936829Not applicable1 country
- The Cleveland Cardiometabolic CohortCompletedNCT030591211 country
- Immunogenicity of Metreleptin in Patients With Generalized LipodystrophyCompletedNCT04026178Phase 41 country
- Hemoglobin Level, Coagulopathy Profile and Electrolyte BalanceCompletedNCT046560541 country
- Cholic Acid for Hepatic Steatosis in LipodystrophyCompletedNCT00457639Phase 21 country
- The Benefits of the Measureof Epicardial Adipose Tissue During Coronary Calcium Assessment of the Refine Cardiovascular Risk Assessment at Reunion Island.CompletedNCT070906291 country
- Carotid Doppler Peak Velocity Variation in Liposuction Fluid ManagementCompletedNCT05930106Not applicable1 country
- Evaluation of HA Dermal Fillers in the Treatment of Pathological Facial LipoatrophyCompletedNCT05776836Not applicable1 country
- Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS)CompletedNCT02914886Phase 4
- Performance and Safety of the Lipo-transfer Cannulas in Patients Underlying Lipofilling TreatmentCompletedNCT060897591 country
- Trial of Leptin Replacement Therapy in Patients With LipodystrophyCompletedNCT00896298Phase 2/31 country
- Intraoperative Fluid Management of Liposuction , Cardiometry Versus Rohrich FormulaCompletedNCT05402982Not applicable1 country
- Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's LipodystrophyCompletedNCT05424913Not applicable1 country
- Safety and Efficacy of Injectable Poly-L-Lactic Acid for Volume Loss in the Temples Using Dual Plane InjectionsStatus unknownNCT05608239Not applicable
- Evaluating the Performance and Safety of the Medical Device Auralya® in the Treatment of Facial Dermal Tissue DefectsStatus unknownNCT05239130Not applicable1 country
- Evaluating the Performance and Safety of the Medical Device Plenhyage® in the Treatment of Dermal Tissue DefectsStatus unknownNCT05239117Not applicable1 country
- Evaluating Performance and Safety of the Medical Device Jalucomplex in the Treatment of Facial and Neck Tissue DefectsCompletedNCT05239351Not applicable1 country
- Evaluating the Performance and Safety of the Medical Device Janesse in the Treatment of Facial Dermal Tissue DefectsCompletedNCT05239156Not applicable1 country
- TH9507 Extension Study in Patients With HIV-Associated LipodystrophyCompletedNCT00608023Phase 36 countries
- Morphological and Functional Evaluation of Buttock Lipoatrophy Treatment With MacrolaneCompletedNCT00931268Not applicable1 country
- Growth Hormone Dynamics and Cardiac Steatosis in HIVCompletedNCT038261601 country
- Effects of a Uridine Supplement on HIV Infected Adults With LipoatrophyCompletedNCT00307164Phase 2/32 countries
- Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood LipidsCompletedNCT00006412Phase 32 countries
- The PREFORM Study: Rotational Fractional Resection for Submental ContouringCompletedNCT03966924Not applicable1 country
- Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.Status unknownNCT04860063Phase 3
- Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL)CompletedNCT03514420Phase 21 country
- CONFORM: Rotational Fractional Resection for Submental ContouringCompletedNCT03407313Not applicable1 country
- Clinical Evaluation of Venus Versa Octipolar Applicator for Reduction of Abdomen CircumferenceTerminatedNCT02492997Not applicable1 country