Drug
Efavirenz clinical trials
Also written Sustiva, EFV, Stocrin and MK-0831.
- studies test it
- 156
- open now
- 3
- in phase 3
- 34
- first study started
- 1997
Keep track of what changes. Save the efavirenz studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
138 studies that test it; most in 2006 (12)
| Year | Studies |
|---|---|
| 1997 | 2 |
| 1999 | 10 |
| 2000 | 3 |
| 2001 | 7 |
| 2002 | 3 |
| 2003 | 2 |
| 2004 | 10 |
| 2005 | 8 |
| 2006 | 12 |
| 2007 | 10 |
| 2008 | 12 |
| 2009 | 6 |
| 2010 | 6 |
| 2011 | 7 |
| 2012 | 6 |
| 2013 | 4 |
| 2014 | 5 |
| 2015 | 3 |
| 2016 | 2 |
| 2017 | 2 |
| 2018 | 4 |
| 2019 | 1 |
| 2020 | 4 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 39
- Phase 2
- 29
- Phase 3
- 34
- Phase 4
- 40
- No phase
- 16
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 51 · Other 105
National Institute of Allergy and Infectious Diseases (NIAID) (20) · Bristol-Myers Squibb (9) · Merck Sharp & Dohme LLC (6) · Kirby Institute (5) · Gilead Sciences (5) · Shanghai Public Health Clinical Center (4) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (4) · St Stephens Aids Trust (4)
Often tested with
Tested in the same studies.
Lamivudine (32) · Tenofovir (21) · Ritonavir (19) · Zidovudine (17) · Lopinavir-ritonavir drug combination (15) · Abacavir (15) · Emtricitabine (14) · Didanosine (13)
Studies
Open first, then newest update. How each study uses efavirenz is read from its arms, and is right about nine times in ten.
Testing it · 156
- Reverse Triple Negative Immune Resistant Breast CancerRecruitingPhase 2Fudan UniversityNCT05076682Written as Efavirenz
- Efavirenz for the Treatment of Creutzfeldt-Jakob DiseaseRecruitingPhase 3Xuanwu Hospital, BeijingNCT07482085Written as Efavirenz
- The T Cell Activator of Cell Killing ("TACK") IT ON" STUDYRecruitingNot applicableUniversity of TorontoNCT06823596Written as Efavirenz 600mg
- Efavirenz (EFV) IntensificationCompletedPhase 4Washington University School of MedicineNCT07193875Written as Efavirenz 600mg
- Pilot Study on Once Daily FTC, ddI, Efavirenz Combination in Antiretroviral Naive HIV Infected AdultsCompletedPhase 2ANRS, Emerging Infectious DiseasesNCT00196599Written as efavirenz (drug)
- Efficacy of Tenofovir-Emtricitabine and Efavirenz in HIV Infected Patients With Tuberculosis (ANRS129)CompletedPhase 3French National Agency for Research on AIDS and Viral HepatitisNCT00115609Written as efavirenz
- Efavirenz as Second-Line Therapy in Treating Patients With Metastatic Pancreatic CancerCompletedPhase 2Institut BergoniéNCT00964171Written as Efavirenz 600mg
- A Study of the Effect Efavirenz on the Plasma Levels of MK-7602 in Healthy Participants (MK-7602-005)CompletedPhase 1Merck Sharp & Dohme LLCNCT06797674Written as Efavirenz
- Bioavailability Mechanistic Study of Hot-Melt Extruded Amorphous Solid DispersionsCompletedNot applicableUniversity Hospital, Basel, SwitzerlandNCT03886766Written as Efavirenz solution
- A Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)CompletedPhase 1Merck Sharp & Dohme LLCNCT06698016Written as Efavirenz
- Pharmacologic Strategies to Use the Levonorgestrel Implant in HIV-infected WomenCompletedPhase 2University of NebraskaNCT02722421Written as Efavirenz
- TGRX-326 Pharmacokinetic Drug InteractionCompletedPhase 1Shenzhen TargetRx, Inc.NCT06294561Written as Efavirenz+TGRX-326
- Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV DiseaseTerminatedPhase 4Rush University Medical CenterNCT00775606Written as Efavirenz
- Efavirenz for Patients With Alzheimer's DiseaseCompletedPhase 1Case Western Reserve UniversityNCT03706885Written as Sustiva Pill
- A Trial of DDI Between SHR1459 and Efavirenz With Healthy SubjectsCompletedPhase 1Jiangsu HengRui Medicine Co., Ltd.NCT05560360Written as Efavirenz tablet
- Drug-drug Interaction Study of Ganaplacide and Lumefantrine With EfavirenzCompletedPhase 1Novartis PharmaceuticalsNCT05330273Written as Efavirenz
- A Study of the Effect of a Moderate CYP3A Inducer Efavirenz on Quizartinib Pharmacokinetics in Healthy ParticipantsCompletedPhase 1Daiichi Sankyo Co., Ltd.NCT04459598Written as Efavirenz
- Efavirenz in Treating Patients With Metastatic Prostate CancerCompletedPhase 2Institut BergoniéNCT00964002Written as efavirenz
- Preventing Sexual Transmission of HIV With Anti-HIV DrugsCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00074581Written as Efavirenz
- Safety and Effectiveness of Emtricitabine, Efavirenz, and Didanosine in HIV Infected Children Who Have Taken Few or No Anti-HIV DrugsCompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT00016718Written as Efavirenz (EFV)
See all 156 studies that test efavirenz →
Given in every arm · 21 — efavirenz is usual care beside what is tested
- REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) TreatmentCompletedPhase 4Advancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsNCT01380080Written as Efavirenz
- A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy ParticipantsCompletedPhase 1PfizerNCT05067439Written as Efavirenz
- Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-naive ParticipantsCompletedPhase 2Alexion Pharmaceuticals, Inc.NCT00350272Written as Efavirenz
- Efficacy of VHM After Treatment Interruption in Subjects Initiating ART During Acute HIV InfectionCompletedPhase 1/2SEARCH Research FoundationNCT02475915Written as Efavirenz
- Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected ChildrenCompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT00260078Written as Efavirenz
- Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected ChildrenCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT00802802Written as Efavirenz (EFV)
- Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients With Both HBV and HIVWithdrawnNot applicableNational Institute of Allergy and Infectious Diseases (NIAID)NCT00051090Written as Efavirenz
- Phase III Clinical Study of Azvudine in Hiv-infected Treatment Naive PatientsStatus unknownPhase 3HeNan Sincere Biotech Co., LtdNCT04303598Written as EFV
- Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-InfectedCompletedPhase 1/2Advancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsNCT01632891Written as Efavirenz
- ESTIMATION OF THE EFFECT OF MULTIPLE DOSE PF-06651600 ON THE PHARMACOKINETICS OF SINGLE DOSE MIDAZOLAM AND EFAVIRENZCompletedPhase 1PfizerNCT03762928Written as efavirenz
- A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy RegimenCompletedPhase 2Michael HoelscherNCT01714414Written as EFV
- Safety, Efficacy and Dose-response Study of BMS-986001 in Subjects With HIV-1 Infection Who Are Treatment-naiveTerminatedPhase 2Bristol-Myers SquibbNCT01489046Written as Efavirenz
- PK TDF in Thai HIV-infected ChildrenCompletedNot applicableThe HIV Netherlands Australia Thailand Research CollaborationNCT02404259Written as Efavirenz
- Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy VolunteersCompletedNot applicableIndiana UniversityNCT01104376Written as Efavirenz
- Part A: Drug Interaction Study of Sofosbuvir and Antiretroviral Therapy (ART) Combinations in HIV and Hepatitis C Virus (HCV) Co-infected Patients. Part B: Efficacy and Safety of Sofosbuvir for 12 Weeks in HIV/HCV Co-infected Patients.CompletedPhase 1/2Gilead SciencesNCT01565889Written as EFV
- Multiple Dose Comparison of the Effect of Two Dose Combinations of Tipranavir/Ritonavir (TPV/RTV), on the Pharmacokinetic Characteristics of Efavirenz (Sustiva®) in Healthy Adult VolunteersCompletedPhase 1Boehringer IngelheimNCT02253823Written as EFV
- Drug-Drug Interaction Study Between Fenofibric Acid and EfavirenzCompletedPhase 1Mutual Pharmaceutical Company, Inc.NCT00960570Written as Efavirenz 600 mg
- A Drug-Drug Interaction Study Between Fenofibric Acid and EfavirenzCompletedPhase 1Mutual Pharmaceutical Company, Inc.NCT01472380Written as efavirenz
- Evaluation of Two Anti-HIV Treatment Strategies in Resource-Limited South African CommunitiesCompletedNot applicableCIPRA SANCT00255840Written as Efavirenz
- Influence of Nevirapine on HCV Viral LoadStatus unknownNot applicableValme University HospitalNCT01277627Written as efavirenz, protease inhibitors
Showing 20 of 21.
As the comparator · 41 — what is tested is compared with efavirenz
- A Single-center, Randomized, Open-label, Parallel-design Clinical Study to Evaluate the Pharmacokinetic Effects of Itraconazole, Fluconazole or Efavirenz on a Single Dose of Clifutinib in Healthy ParticipantsNot yet recruitingPhase 1Sunshine Lake Pharma Co., Ltd.NCT07341672Written as efavirenz
- Impact of a Dolutegravir-based Regimen on Early Mortality of AIDS PatientsCompletedPhase 2/3Fundação Bahiana de InfectologiaNCT01837277Written as Efavirenz-based regimens
- Efficacy and Safety of a Dolutegravir-based Regimen for the Initial Management of HIV Infected Adults in Resource-limited SettingsCompletedPhase 3ANRS, Emerging Infectious DiseasesNCT02777229Written as Efavirenz 400 mg
- Hepatic Safety of Raltegravir Versus Efavirenz as HIV Therapy for Patients With HIV and HCV CoinfectionCompletedPhase 4University of HawaiiNCT01147107Written as Efavirenz
- A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line TreatmentCompletedPhase 3Janssen-Cilag International NVNCT01709084Written as Efavirenz
- Dose Ranging Study of GSK1265744 Plus Nucleoside Reverse Transcriptase Inhibitors for Induction of Human Immunodeficiency Virus-1 (HIV-1) Virologic Suppression Followed by Virologic Suppression Maintenance by GSK1265744 Plus RilpivirineCompletedPhase 2ViiV HealthcareNCT01641809Written as Efavirenz 600 mg
- Efavirenz and Ritonavir on Human Brain P-GlycoproteinCompletedPhase 1/2Washington University School of MedicineNCT01668147Written as Oral efavirenz
- Raltegravir Cerebrospinal Fluid Pharmacodynamic Study in HIV-Infected IndividualsTerminatedNot applicableUniversity of California, San DiegoNCT01293123Written as Efavirenz
- A Dose-Ranging Study to Compare Doravirine (MK-1439) Plus TRUVADA® Versus Efavirenz Plus TRUVADA® in Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-1439-007)CompletedPhase 2Merck Sharp & Dohme LLCNCT01632345Written as Efavirenz
- Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant WomenCompletedPhase 3University of California, San FranciscoNCT00993031Written as Efavirenz
- Switching TDF/FTC/EFV to TDF/FTC/RPV VS Continuing TDF/FTC/EFV in HIV Patients With Complete Virological SuppressionCompletedNot applicableMahidol UniversityNCT03251690Written as Tenofovir/Emtricitabine/Efavirenz
- Efficacy, Safety and Optimal Dose of VM-1500 in Comparison to Efavirenz Added to Standard-of-care Antiretroviral TherapyCompletedPhase 2/3ViriomNCT02489461Written as Efavirenz
- Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive AdultsTerminatedPhase 2ViiV HealthcareNCT02415595Written as EFV
- A Dose Ranging Trial of GSK1349572 and 2 NRTI in HIV-1 Infected, Therapy Naive SubjectsCompletedPhase 2ViiV HealthcareNCT00951015Written as efavirenz
- Dose-finding Study of GSK2248761 in Antiretroviral Therapy-Naive Subjects (SIGNET)TerminatedPhase 2ViiV HealthcareNCT01231555Written as Efavirenz 600 mg once daily
- Switching From Efavirenz to Atazanavir/ Ritonavir in HIV-infected Subjects With Good Virologic SuppressionTerminatedPhase 4The Cleveland ClinicNCT01194856Written as Efavirenz
- Human Immunodeficiency Virus (HIV) Postexposure Prophylaxis (PEP) With Darunavir/Ritonavir (DRV/r)CompletedPhase 3Janssen-Cilag G.m.b.HNCT01516970Written as Efavirenz
- Evolution of Plasma Lipid Profile in Patients With HIV1 Who Change Atripla to Eviplera Compared to Continue With AtriplaCompletedPhase 4Hospital Universitari Vall d'Hebron Research InstituteNCT02547844Written as efavirenz + emtricitabina + tenofovir
- Decrease of Neuropsychiatric Side Effects After Switching From Atripla to EvipleraTerminatedPhase 4Sheba Medical CenterNCT02447016Written as Tenofovir disoproxil/emtricitabine/efavirenz
- A Study to Evaluate the Safety and Antiretroviral Activity of MK-0518 Versus Efavirenz in Treatment Naive HIV-Infected Patients, Each in Combination With TRUVADA (0518-021 EXT)CompletedPhase 3Merck Sharp & Dohme LLCNCT00369941Written as Comparator: efavirenz
Showing 20 of 41.
Codes
What other systems call efavirenz · ClinicalTrials.gg INT003893
- MeSH (NLM) C098320efavirenzConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) JE6H2O27P8EFAVIRENZConfirmed FDA, NLM, Wikidata
- RxNorm 195085Confirmed FDA, Wikidata
- Wikidata Q422645efavirenzConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29027EfavirenzOne source FDA
- DrugBank DB00625One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C098320 | efavirenz | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | JE6H2O27P8 | EFAVIRENZ | Confirmed FDA, NLM, Wikidata |
| RxNorm | 195085 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422645 | efavirenz | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29027 | Efavirenz | One source FDA |
| DrugBank | DB00625 | — | One source Wikidata |
Also registered as efavirenz, (r)- (UNII CEE19E5D5F).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.