National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Lipodystrophy trials

The registry lists 13 Lipodystrophy studies with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as lead sponsor. 3 are open to participants now and 5 have results posted.

Phase 1 1Phase 2 6Phase 3 1Phase 4 1No phase 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Effects of Meal Macronutrients on Postprandial LipidsNot yet recruitingNCT07313787Phase 2
• Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)RecruitingNCT05996536
• Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With LipodystrophyRecruitingNCT05419037
• Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label ExtensionCompletedNCT02639286Phase 2Results posted
• Short-term Effects of Leptin in People With LipodystrophyCompletedNCT01778556Phase 2Results posted
• Myocardial Function & FFA Metabolism in HIV Metabolic SyndromeCompletedNCT00656851Not applicableResults posted
• Exercise and Pioglitazone for HIV-Metabolic SyndromesCompletedNCT00639457Not applicableResults posted
• Leptin to Treat LipodystrophyCompletedNCT00025883Phase 2Results posted
• Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyActive, not recruitingNCT02262832Phase 3
• Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyActive, not recruitingNCT02262806Phase 2
• A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop LipodystrophyCompletedNCT00006190Phase 4
• Underlying Abnormalities in Fat and Muscle Leading to Lipodystrophy SyndromeCompletedNCT00006185Phase 1
• Leptin to Treat LipodystrophyCompletedNCT00005905Phase 2