Laryngeal Diseases clinical trials
The registry lists 147 studies for Laryngeal Diseases across more than 10 countries. 26 are recruiting or about to start. 53 of them are mainly about Laryngeal Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 10 narrower conditions too, such as Laryngeal Neoplasms: 790 studies, 184 open.
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Who runs them
University of Chicago (5) · Vanderbilt University (4) · Vanderbilt-Ingram Cancer Center (3) · National Cancer Institute (NCI) (3) · Sidney Kimmel Cancer Center at Thomas Jefferson University (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Boston Medical Center (2) · Memorial Sloan Kettering Cancer Center (2)
What is being tested here
Drugs under test in Laryngeal Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ficerafusp alfa | 2 | 1 | 2 |
| Panitumumab | 2 | 0 | 2 |
| IRDye800 | 2 | 0 | 2 |
| Cisplatin | 1 | 2 | 7 |
| Cetuximab | 1 | 0 | 5 |
| Zopapogene imadenovec | 1 | 0 | 1 |
| Triamcinolone Acetonide | 1 | 0 | 1 |
| Triamcinolone | 1 | 0 | 1 |
| Fluorouracil | 1 | 0 | 1 |
| Docetaxel | 1 | 0 | 1 |
Drug classes tested here Antimetabolites 1 open · Tyrosine kinase inhibitors (TKIs) 1 open · Immune checkpoint inhibitors 6 · Proton pump inhibitors (PPIs) 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026AI System for Anatomic Recognition & Lesion Detection in Nasopharyngolaryngoscopy: A Prospective Study · Ruijin Hospital
- Jan 2027Force Sensor Study · University of California, San Francisco
- Feb 2027Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery · Clinique Saint-Vincent
- Mar 2027Two-cohort Study of Niraparib and Dostarlimab Plus (Chemo)RadIotherapy in Locally-Advanced Head and Neck Squamous Cell Carcinoma · Grupo Español de Tratamiento de Tumores de Cabeza y Cuello
- May 2027High-Resolution PET-CT Imaging for Surgical Margin Visualization · Vanderbilt-Ingram Cancer Center
- Jun 2027Efficacy of Intramuscular Steroid Injection for Chronic Cough. · Medical University of South Carolina
Who these studies take
Of the 21 Laryngeal Diseases studies recruiting now, 17 (81%) set no upper age limit and 1 (5%) stop at 75 or younger. 3 (14%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (10%) | 2 (10%) |
| 18 | 20 (95%) | 20 (95%) |
| 30 | 21 (100%) | 21 (100%) |
| 40 | 21 (100%) | 21 (100%) |
| 50 | 21 (100%) | 21 (100%) |
| 65 | 21 (100%) | 21 (100%) |
| 75 | 20 (95%) | 20 (95%) |
| 85 | 19 (90%) | 19 (90%) |
Across all 147 studies, recruiting or not: 19% stop at 75 or younger and 12% at 65; 18% take children; 2% are for women only and 0% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Laryngeal Diseases studies take
Of 29 interventional studies with no phase under Laryngeal Diseases, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 24 mo13–52 · 29 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Results posted1
Stopped2
- Assessment of Laryngopharyngeal Sensation: Cancer Survivor CohortSuspendedNov 5, 2026NCT06078527
- Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and NeckTerminatedOct 19, 2026NCT03854032
Studies
Recruiting first, then most recently updated. Showing 50 of 147. Browse all 147 → or search them.
- Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)Not yet recruitingNCT07756840Phase 21 country
- Biospecimen Procurement for Head and Neck DisordersRecruitingNCT034290361 country
- VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or LymphomaRecruitingNCT03556228Phase 1/22 countries
- FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCCRecruitingNCT06788990Phase 2/328 countries
- Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell CarcinomaRecruitingNCT07741643Phase 11 country
- A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCCRecruitingNCT07807163Phase 21 country
- NIDCD Otolaryngology Clinical Protocol Biospecimen BankRecruitingNCT063031801 country
- Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerRecruitingNCT06819228Phase 11 country
- Efficacy of Intramuscular Steroid Injection for Chronic Cough.RecruitingNCT06634823Early Phase 11 country
- p-PHOTOLARYNX- ANTHEM: Photon-Counting CT in Laryngeal Cancer StagingEnrolling by invitationNCT076031671 country
- High-Resolution PET-CT Imaging for Surgical Margin VisualizationRecruitingNCT06915454Not applicable1 country
- 5-Fluorouracil Response and Optimization STudy (The FROST Trial)RecruitingNCT07419464Phase 21 country
- Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction DesignRecruitingNCT02128906Phase 21 country
- Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT SurgeryRecruitingNCT06600919Not applicable1 country
- Force Sensor StudyRecruitingNCT07434583Not applicable1 country
- CONFIRM: Magnetic Resonance Guided Radiation TherapyRecruitingNCT04368702Not applicable1 country
- Accuracy of the Sensory Test Using the Laryngopharyngeal Endoscopic Esthesiometer in Obstructive Sleep ApneaRecruitingNCT03109171Not applicable1 country
- AI System for Anatomic Recognition & Lesion Detection in Nasopharyngolaryngoscopy: A Prospective StudyRecruitingNCT073263581 country
- Phase II Randomized Study of Hypofractionated Versus Conventional RadiotherapyRecruitingNCT06080503Not applicable1 country
- Factors Affecting Outcomes of Using Diode Laser Both 980 nm Wave Length and 450 Wavelength on Benign Laryngeal Lesions in Comparison to Traditional Cold Instrumentations as Regard Parameters of Laser Device, Nature of Lesion and Patient FactorsEnrolling by invitationNCT06912945Not applicable1 country
- Classification and Prediction of Difficult Awake Tracheal Intubation With Flexible BronchoscopesRecruitingNCT069534141 country
- Pilot Feasibility Study of Laryngeal Ultrasound in the Paediatric Population - ECHO LARYNXNot yet recruitingNCT065592931 country
- Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway SurgeryRecruitingNCT06507202Phase 41 country
- Prevalence of EILO Among Children With AsthmaNot yet recruitingNCT06480084Not applicable1 country
- Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and ChondrolaryngoplastyRecruitingNCT06439290Not applicable1 country
- HelpILO - RCT on EILO TreatmentRecruitingNCT04620343Not applicable1 country
- Effectiveness of Two Diaphragmatic Strengthening Programs on Symptoms of LPR as Measured by the Reflux Symptom Index (RSI) and the Reflux Disease Questionnaire (RDQ)CompletedNCT07931105Not applicable1 country
- Assessment of Laryngopharyngeal Sensation: Cancer Survivor CohortSuspendedNCT060785271 country
- A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)Active, not recruitingNCT06525220Phase 328 countries
- Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHNCompletedNCT03529422Phase 21 country
- Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and NeckTerminatedNCT03854032Phase 21 country
- Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RTActive, not recruitingNCT03340896Phase 31 country
- Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck CancerActive, not recruitingNCT04590963Phase 323 countries
- Laryngeal Allograft TransplantationSuspendedNCT03269396Not applicable1 country
- Flow-Controlled Versus Volume-Controlled Ventilation During Suspension LaryngoscopyCompletedNCT076393981 country
- Two-cohort Study of Niraparib and Dostarlimab Plus (Chemo)RadIotherapy in Locally-Advanced Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT05784012Phase 1/21 country
- Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal SurgeryCompletedNCT06316063Not applicable1 country
- High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General AnesthesiaTerminatedNCT03472118Not applicable1 country
- Interventional Study Collecting Quantitative and Qualitative Data About Patient With Non Treated CancerTerminatedNCT01647477Not applicable1 country
- A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function MutationsCompletedNCT05199584Phase 21 country
- Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal CancersCompletedNCT03656133Not applicable1 country
- Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)TerminatedNCT05386550Phase 326 countries
- Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell CarcinomaTerminatedNCT03076281Phase 21 country
- The Objective is to Respond to Patients' Needs in the Field of Larynx ReplacementCompletedNCT00576134Phase 11 country
- Study Title: Oncological and Functional Results After Total Laryngectomy and PharyngolaryngectomyActive, not recruitingNCT072878651 country
- Pembrolizumab in Combination With CRT for LA-SCCHNCompletedNCT02586207Phase 11 country
- The Head and Neck Tumor BiobankCompletedNCT016447861 country
- Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)TerminatedNCT06056310Phase 16 countries
- Sugammadex v.s. Neostigmine/GlycopyrrolateCompletedNCT06398899Not applicable1 country
- Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.CompletedNCT055654301 country