An interventional study of Standard abdominal breathing and Resisted Exercise in Laryngeal/Pharyngeal Reflux (LPR), sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment
Among 72 studies in Laryngeal Diseases with a site in United States — 15 open to participants now, 17 under way, 3 of them phase 3. Laryngeal Diseases · United States.
Among the 72 studies in Laryngeal Diseases with a site in United States, this one is the 17th largest by enrollment of the 61 interventional ones that give a count, is one of 2 that started in 2023, is one of 16 with no phase, and was the 72nd registered.
146 studies on the registry are indexed under Laryngeal Diseases; 26 are open to participants now.
Browse Laryngeal Diseases studies →15 of the 72 studies in Laryngeal Diseases with a site in United States are open now. Recruiting first, the newest first:
Vanderbilt-Ingram Cancer Center · Sites in United States
Ages 18+
Bicara Therapeutics · Sites in United States
Ages 18+
Washington University School of Medicine · Sites in United States
Ages 18+
University of California, San Francisco · Sites in United States
Ages 18+
Vanderbilt-Ingram Cancer Center · Sites in United States
Ages 18+
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 21 Laryngeal Diseases studies recruiting now, 17 (81%) set no upper age limit and 1 (5%) stops at 75 or younger; 3 take children under 18; 2 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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72 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 14 · Phase 2 22 · Phase 3 11 · Phase 4 4
First in 1996; this study’s year is marked. 2 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 69 is above the median of 50 across 108 interventional studies indexed under Laryngeal Diseases.
Median enrollment 46 across the 61 interventional studies, 368 across the 10 observational. Of the 52 that completed or were terminated, 24 (46%) have results posted.
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14 of 72 have an industry lead sponsor. The 10 most frequent:
Mayo Clinic is the lead sponsor of 3,270 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Mayo Clinic has 2 studies filed under Laryngeal Diseases — fewer than ten, so there is no comparison to draw.
3 of the studies in Laryngeal Diseases with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07434583University of California, San FranciscoForce Sensor Study | 2027-01-31 |
| NCT06915454Vanderbilt-Ingram Cancer CenterHigh-Resolution PET-CT Imaging for Surgical Margin Visualization | 2027-05 |
| NCT06634823Medical University of South CarolinaEfficacy of Intramuscular Steroid Injection for Chronic Cough. | 2027-06-30 |
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Among the 72 studies in Laryngeal Diseases with a site in United States, from their registry updates:
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The researchers are exploring the effectiveness of a new method of controlling symptoms associated with LPR. Those symptoms may include hoarseness, throat clearing, globus (lump in the throat) sensation, excessive throat mucus, postnasal drip and coughing. Initial studies have been performed that indicate abdominal breathing exercises can reduce symptoms associated with reflux. This may represent a simple and inexpensive means of controlling symptoms associated with a very common disorder. The researchers wish to extend these studies on a set of other reflux-related conditions.
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Exclusion Criteria:
Participants will complete 10 repetitions of abdominal breathing before and after each meal with no resistance.
Other: Standard abdominal breathing
Participant will complete abdominal breathing 15 minutes per day with resistance applied to the abdomen by the participant.
Other: Resisted Exercise
10 repetitions of abdominal breathing before and after each meal with no resistance.
Abdominal breathing 15 minutes per day with resistance (participant folds arms across the belly) applied to the abdomen by the participant.
Change in Reflux Symptom Index (RSI) Score
The RSI is a 9-item questionnaire evaluating the severity of nine common LPR-related throat and voice symptoms over the past month. Each symptom is rated from 0 (no problem) to 5 (severe problem), with total scores ranging from 0-45. Higher scores indicate greater laryngopharyngeal reflux symptom severity.
Time frame: Baseline, 1 month, 3 months, 6 months
Change in Reflux Disease Questionnaire (RDQ) Score
The RDQ is used to quantify gastroesophageal reflux disease (GERD) symptoms in adults. The RDQ has six symptom items (heartburn, regurgitation, dyspepsia). Each item is rated on two separate 0-5 scales: Frequency (0 = never, 5 = daily) and Severity (0 = did not have, 5 = severe). Each item's frequency + severity sum is averaged across the two items in that symptom dimension, and the overall RDQ score is the mean of all 12 ratings (6 items × 2 facets). Higher scores indicate greater reflux symptom severity.
Time frame: Baseline, 1 month, 3 months, 6 months
Plan to share: No
Ran from May 2023 to primary completion in May 2025, 24 months.
Of 28 interventional studies with no phase under Laryngeal Diseases, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 52. This study's 24 months is close to that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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