An interventional study of Nasal High Flow Oxygen in Laryngoscopy, Apnea and Anesthesia, sponsored by CMC Ambroise Paré. Terminated at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-08.
Sponsored by CMC Ambroise Paré · Not applicable, Interventional, and Treatment
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Among 19 studies in Apnea with a site in France — 2 open to participants now, 3 under way, none of them phase 3. Apnea · France.
Among the 19 studies in Apnea with a site in France, this one is the 10th largest by enrollment of the 14 interventional ones that give a count, is one of 2 that started in 2018, is one of 12 with no phase, and was the 12th registered.
282 studies on the registry are indexed under Apnea; 54 are open to participants now.
Browse Apnea studies →2 of the 19 studies in Apnea with a site in France are open now. Recruiting first, the newest first:
University Hospital, Grenoble · Sites in France
Ages 6+
University Hospital, Limoges · Sites in France
Ages 24 wk–34 wk
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 40 Apnea studies recruiting now, 9 (23%) set no upper age limit and 27 (68%) stop at 75 or younger; 19 take children under 18; 16 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
19 studies; the count open now beside each. This study's row is marked.
First in 2006; this study’s year is marked. 2 started in 2018.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 29 is below the median of 60 across 195 interventional studies indexed under Apnea.
Median enrollment 64 across the 14 interventional studies, 120 across the 5 observational. Of the 13 that completed or were terminated, 0 (0%) have results posted.
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2 of 19 have an industry lead sponsor. The 10 most frequent:
CMC Ambroise Paré is the lead sponsor of 47 studies on the registry; 8 are open to participants now.
CMC Ambroise Paré has 1 study filed under Apnea — fewer than ten, so there is no comparison to draw.
2 of the studies in Apnea with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06061562University Hospital, GrenobleDown Syndrome, Physical Activity and Sleep Apnea | 2026-12-31 |
| NCT07779915University Hospital, LimogesMICropsampling for CAffeine in PREMature Newborns | 2027-10-01 |
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Among the 19 studies in Apnea with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Patients undergoing suspension laryngoscopy under general anaesthesia have oxygen delivered to their lungs through different methods. Inserting a tube in the trachea is the best means for oxygen delivery. However, it does not allow for optimal visibility of the operated area. Other techniques can be used but have disadvantages with some being associated with serious complications. No consensus exists regarding the best airway management technique for this intervention.
The aim of the study is to investigate a new device that delivers oxygen at very high flow through a nasal cannula in patients undergoing suspension laryngoscopy under general anaesthesia. This technique allows the surgeon to have a perfect visualisation of the laryngeal structures while allowing the delivery of oxygen for the lungs.
After informed consent, adult patients undergoing suspension laryngoscopy under general anaesthesia in two French hospitals will receive high flow oxygen throughout the procedure. At the end of surgery or, whenever applicable, at the time of technique failure (with a decrease in blood oxygen saturation to less than 92%), blood will be drawn for analysis. All patients will have a thin security catheter inserted in their trachea (the currently used technique in both participating hospitals), allowing for rescue high frequency ventilation if ever the study technique fails.
The safety of the device will also be assessed by analysing the blood samples for signs of carbon dioxide accumulation and by collecting any intra or post-operative complications.
If the device shows to be effective at maintaining blood oxygenation without significant associated risks, it could be used for other surgical situations where airway management is expected to be difficult.
Suspension laryngoscopy is a surgical intervention for which no airway management recommendations exist.
Many techniques are used, each having limitations. While tracheal intubation is the gold standard of airway management, in this particular intervention, it does not allow for optimal visualisation of the larynx. Maintaining spontaneous ventilation under general anaesthesia is used by some teams but puts the patient at the risk of laryngospasm. Apneic oxygenation is another option but its use is limited by the associated risk of hypercapnia. High frequency jet ventilation allows for good surgical conditions, satisfactory blood oxygen delivery and a low risk of hypercapnia; however, its use has been associated with severe, sometimes deadly, complications.
Nasal High Flow oxygenation is a relatively novel technique that allows for the delivery of heated and humidified oxygen with flow ranging up to 70l/min. It is widely used in neonatal and adult critical care. Its use in apneic patients under general anaesthesia has been reported to be associated with a mean of 14 minutes of desaturation-free apnea time with limited risk of hypercapnia. Desaturation-free apnea times up to 60 minutes have been reported. The use of nasal high flow apneic oxygenation in suspension laryngoscopy has been reported once in the literature with encouraging results.
The aim of the study is to assess the efficacy of nasal high flow oxygen in maintaining normal blood oxygen saturation (>95%) in apneic patients undergoing suspension laryngoscopy under general anaesthesia.
Adult patients undergoing suspension laryngoscopy (laser surgeries and cavoscopies excluded) in two french hospitals will be screened for eligibility by the anaesthesiologist during the preoperative consultation. Consenting and eligible patients will be enrolled in the study.
After pre oxygenation (until etO2 >90%), general anaesthesia will be started and maintained using TIVA propofol and remifentanil. Neuromuscular blockade will be achieved using rocuronium.
As soon as apnea is obtained, nasal high flow oxygen will be started at 70l/min using Simplified OptiflowTM (Fisher \& Paykel Healthcare Ltd, Auckland, New Zealand) . A transglottic high frequency jet ventilation catheter will also be placed in the trachea to allow for emergency ventilation if high flow oxygenation fails to maintain SpO2>92%.
Oxygen saturation, blood pressure, pulse rate, BIS and neuromuscular blockade will be monitored throughout the surgery.
At the end of surgery (maximum 30 minutes), or as soon as blood oxygen saturation falls below 92%, whichever comes first, arterial blood for blood-gas analysis (PaO2, PaCO2, pH) will be drawn.
Neuromuscular blockade will be reversed with neostigmine or sugammadex depending on the depth of nerve block.
If the technique is shown to be associated with a low risk of blood oxygen desaturation and of severe hypercapnia, it could be considered for predictable difficult airway management.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Apneic oxygenation using Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE)
Device: Nasal High Flow Oxygen
Nasal High Flow Oxygen during apnoea using Optiflow device of Fisher and Paykel
Incidence of oxygen desaturation SpO2<95% in the first fifteen minutes of apnea in patients undergoing suspension laryngoscopy under general anesthesia and receiving nasal high flow oxygen
Time frame: throughout the first fifteen minutes following the start of apnea, ie following general anesthesia and neuromuscular blockade
Incidence of oxygen desaturation SpO2<95% throughout surgery
Time frame: throughout surgery (maximum thirty minutes)
Duration between start of apnea and oxygen desaturation spO2<95%
Time frame: throughout surgery (maximum thirty minutes)
Incidence of hypercapnia (PaCO2>60mmHg) at the end of surgery or at technique failure
Time frame: At the end of surgery (maximum thirty minutes) or at technique failure (upon blood oxygen desaturation SpO2<92%)
Plan to share: No
Ran from Jul 2018 to primary completion in Jan 2019, 6 months.
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This study is terminated, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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CMC Ambroise Paré